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OAS2

  • Official Full Name

    2-5-oligoadenylate synthetase 2, 69/71kDa

  • Overview

    This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms

    OAS2; 2-5-oligoadenylate synthetase 2, 69/71kDa; 2 5 oligoadenylate synthetase 2 (69 71 kD); 2-5-oligoadenylate synthase 2; (2-5)oligo(A) synthetase 2; 2-5-oligoadenylate synthetase 2; 2-5A synthetase 2; MGC78578; p69 OAS / p71 OAS; p69OAS / p71OAS; 2-5A synthase 2;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human OAS2-3614HCL Recombinant Human OAS2 293 Cell Lysate HEK293 N/A
Human OAS2-4755H Recombinant Human OAS2 Protein (Val11-His346), His tagged E.coli His Val11-His346
Human OAS2-309H Recombinant Human OAS2 Protein, His-tagged E.coli His Val11~His346
Mouse OAS2-11042M Recombinant Mouse OAS2 Protein Mammalian Cell His
Mouse OAS2-6295M-B Recombinant Mouse OAS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse OAS2-6295M Recombinant Mouse OAS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat OAS2-4144R Recombinant Rat OAS2 Protein Mammalian Cell His
Rat OAS2-3806R-B Recombinant Rat OAS2 Protein Pre-coupled Magnetic Beads HEK293
Rat OAS2-3806R Recombinant Rat OAS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig OAS2-1161P Recombinant Pig OAS2 Protein, His-tagged E.coli N-His Gln21-Gln436
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • OAS2 Related Gene Family

OAS2 involved in several pathways and played different roles in them. We selected most pathways OAS2 participated on our site, such as Hepatitis C, Measles, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with OAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hepatitis CPIK3R3;IFNA5;IFNA10;PPP2R1B;RIPK1;EIF3E;MAPK12;MAPK11;CLDN8
MeaslesOAS3;OAS2;STAT3;IRAK4;CD3G;MSN;EIF2AK1;PIK3R3;PIK3CD
Influenza AMAPK1;BMA2;AGFG1;TNF;MAP2K2;IL18;PABPN1L;IFNA6;OAS1A
Herpes simplex infectionMHC1UXA2;STAT1A;IFNA13;HLA-DRA;IFNA4;NXF2;USP7;PER2;H2-AA

OAS2 has several biochemical functions, for example, 2-5-oligoadenylate synthetase activity, ATP binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OAS2 itself. We selected most functions OAS2 had, and list some proteins which have the same functions with OAS2. You can find most of the proteins on our site.

Function Related Protein
2-5-oligoadenylate synthetase activityOASL2;OAS3;OAS2;OAS1;OAS1A
ATP bindingATP2A2;FBXO18;ATP2A1;UCK2A;KIF18A;HSPA2;PRKACB;PC;CDKL2
double-stranded RNA bindingELAVL1;DICER1;MYH4;ACTN1;AGO3;DROSHA;RNASEN;STAU2;TARBP2
metal ion bindingGUCY1B3;ZNF511;AGBL1;LMO7A;KLF15;TRIM26;ITGAM;UBA5;ZNF652
protein bindingLPAR1;SPN;LARS;ENG;CC2D1B;ZNF707;MGRN1;NRBP1;MSLN
zinc ion bindingHIF1AN;CPXM1;NR2E1;GM3258;ZFP326;TRIM28;LIMS2;MKRN4;ZCCHC4

OAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of OAS2.

CLK3

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