Background
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
Synonyms
ORC3; origin recognition complex, subunit 3; ORC3L, origin recognition complex, subunit 3 (yeast homolog) like , origin recognition complex, subunit 3 honolog (yeast) , origin recognition complex, subunit 3 like (yeast); origin recognition complex subunit 3; IMAGE50150; LATHEO; Homolog of Latheo; homolog of latheo, Drosophila; LAT; LATHEO, drosophila, homolog of; ORC3_HUMAN; Origin Recognition Complex Subunit 3 Isoform 1; Origin recognition complex subunit Latheo; Origin Recognition Complex, subunit 3, S. cerevisiae, homolog of; Origin recognition complex, subunit 3-like (S. cerevisiae); Origin recognition complex, subunit 3-like (yeast); origin recognition complex, subunit 3-like; origin recognition complex, subunit 3 honolog; ORC3L