This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants.
Nguyen, NUN; Liang, VR; et al. Actin-associated protein palladin is required for migration behavior and differentiation potential of C2C12 myoblast cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 452:728-733(2014).
von Nandelstadh, P; Gucciardo, E; et al. Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton. MOLECULAR BIOLOGY OF THE CELL 25:2556-2570(2014).