PGK1
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Official Full Name
phosphoglycerate kinase 1
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Overview
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. -
Synonyms
PGK1; phosphoglycerate kinase 1; PRP 2; primer recognition protein 2; cell migration-inducing gene 10 protein; PGKA; MIG10; MGC8947; MGC117307; MGC142128;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Chicken
- Chinese hamster
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Human
- Human Cells
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- PGK1 Related Articles
- PGK1 Related Research Area
PGK1 involved in several pathways and played different roles in them. We selected most pathways PGK1 participated on our site, such as Glycolysis / Gluconeogenesis, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | ADH1B;ACSS1;GPI1;PGK1;ADH1;ADH6;ALDH2.1;LDHAL6B;ALDOCB |
| Metabolic pathways | ACOX2;ALG2;ADSL;MBOAT2;CBSA;POLR2I;NDUFS5;MAOB;HIBADHB |
| Carbon metabolism | H6PD;MDH1AA;GAPDH;GPT2;GPR19;SDHC;GPIA;MUT;PDHA1B |
| Biosynthesis of amino acids | PHGDH;SHMT2;PYCR1A;PGAM1;MTR;PKLR;SDS;CPS1;GLUL |
| HIF- signaling pathway | PGK1;FLT1;HKDC1;PDHA1;NFKB1;HK2;EIF4E1B;RBX1;PRKCG |
PGK1 has several biochemical functions, for example, ATP binding, phosphoglycerate kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PGK1 itself. We selected most functions PGK1 had, and list some proteins which have the same functions with PGK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CLCN3;DDX39AA;ZAK;MYO19;AKT1;UBE2A;ENTPD2;CTPS2;TRNT1 |
| phosphoglycerate kinase activity | PGK2;PGK1 |
| protein binding | RNF216;SNX7;PSMB7;RNF111;MAX;Kitl;ANAPC4;CREB5;PRPF4B |
PGK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PGK1.
GAPDH; PIK3C2A; FOXO3; GBAS; Cdk1; PCNA; PRKAG1; YWHAZ; Bles03; NRBF2; ATG101; DDA1; UBA5; Csnk1e; SH3GLB2; PRKAG2; p29991-pro_0000037945; tnpA; pstS
- Q&As
- Reviews
Q&As (5)
Ask a questionPGK1 dysfunction has been associated with neurological conditions like Alzheimer's disease and Parkinson's disease due to its impact on cellular energy metabolism.
PGK1 is often upregulated in cancer cells, aiding their rapid growth and proliferation by enhancing glycolysis, known as the Warburg effect.
Research suggests that targeting PGK1 could potentially be a strategy for cancer therapy by disrupting the energy production in cancer cells.
Several compounds that modulate PGK1 activity are being studied, but none have reached widespread clinical use yet.
Yes, elevated levels of PGK1 have been identified in certain cancers, making it a potential biomarker for cancer detection and prognosis.
Customer Reviews (3)
Write a reviewmanufacturers may offer customization options, allowing researchers to tailor the PGK1 protein to their specific needs.
This may include options like different formulations, protein modifications, or tagging techniques. Customization can enhance the versatility of the protein and optimize its utility in the intended research.
They can also address any questions or concerns regarding the PGK1 protein, thereby facilitating smooth and efficient research execution.
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