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POLG

Official Full Name

polymerase (DNA directed), gamma
Overview

exhibits DNA polymerase activity; may mediate the final step of mitochondrial DNA repair
Synonyms

POLG; polymerase (DNA directed), gamma; DNA polymerase subunit gamma-1; POLG1; POLGA; PolG-alpha; PolG, catalytic subunit; mitochondrial DNA polymerase catalytic subunit; PEO; MDP1; SCAE; MIRAS; SANDO; MTDPS4A; MTDPS4B; FLJ27114;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Hepatitis C virus genotype 1b
Human
Rat

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
Tag Free

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLG-1832H	Recombinant Human POLG, GST-tagged	E.coli	GST	888-1239aa	$319 / 25ug
Human	POLG-28364TH	Recombinant Human POLG	Wheat Germ	N/A	110 amino acids	Inquiry
Human	POLG-1525H	Recombinant Human POLG protein	E.coli	N/A		Inquiry
Human	POLG-632H	Recombinant Human POLG protein		N/A		Inquiry
Human	POLG-317H	Recombinant Human POLG Protein, His-tagged	E.coli	His	Trp1041~Pro1239	$298 / 10ug
Rat	POLG-4565R	Recombinant Rat POLG Protein	Mammalian Cell	His		Inquiry
Rat	POLG-4225R	Recombinant Rat POLG Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	POLG-4225R-B	Recombinant Rat POLG Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Hepatitis C virus genotype 1b	POLG-1528H	Recombinant Hepatitis C virus genotype 1b POLG Protein (S2420-R2989)	E.coli	Tag Free	S2420-R2989	Inquiry
Hepatitis C virus genotype 1b	POLG-1529H	Recombinant Hepatitis C virus genotype 1b POLG Protein (S2420-R2989), His-tagged	E.coli	His	S2420-R2989	Inquiry

Involved Pathway
Protein Function
Interacting Protein
POLG Related Articles

POLG involved in several pathways and played different roles in them. We selected most pathways POLG participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolic pathways	AMY1A;GATM;PTGS2A;PAPSS2B;PGP;DAO1;APIP;AMT;COX10

POLG has several biochemical functions, for example, 3-5 exonuclease activity, DNA binding, DNA-directed DNA polymerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLG itself. We selected most functions POLG had, and list some proteins which have the same functions with POLG. You can find most of the proteins on our site.

Function	Related Protein
3-5 exonuclease activity	RAD9A;REV3L;POLE;APEX1;POLG;POLA1;EXD1;TREX1;ERI1
DNA binding	THAP6;HIF3A;NOSTRIN;ARID4A;MIER1B;TEAD4;MSL3;RX2;CXXC4
DNA-directed DNA polymerase activity	POLE3;POLD4;POLG2;POLL;DNTT;POLD2;POLH;POLD3;CCDC111
chromatin binding	RFX4;SMARCA2;FOXC1A;SIRT6;FOXO1;CCNT1;HIF1AB;GABPA;TOX
protease binding	XBP1;MBP;TNFAIP3;SEMG2;SRI;LRP1;TIMP2A;Serpina1c;NFRKB
protein binding	CD300A;ADRA2B;SPRTN;SLC6A18;SIGLEC5;CRCT1;CXorf40A;BPIFA2;EDA2R

POLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLG here. Most of them are supplied by our site. Hope this information will be useful for your research of POLG.

POLG2; Dlg4; q2i360_hbv; ssdna_dn

Arkadir, D; Meiner, V; et al. Teaching NeuroImages: Hypertrophic olivary degeneration in a young man with POLG gene mutation. NEUROLOGY 84:e59-e59(2015).

Golob, MJ; Tian, L; et al. Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function. JOURNAL OF BIOMECHANICS 48:405-412(2015).