PPP2CB
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Official Full Name
protein phosphatase 2, catalytic subunit, beta isozyme
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Overview
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. -
Synonyms
PPP2CB; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2Abeta; protein phosphatase 2A catalytic subunit; beta isoform; PP2A beta; PP2A-beta; PP2AB_HUMAN; PP2CB; Protein phosphatase 2 catalytic subunit beta isozyme; Protein phosphatase 2, catalytic subunit, beta isoform; Protein phosphatase 2A catalytic subunit beta isoform; Protein phosphatase type 2A catalytic subunit; Serine/threonine protein phosphatase 2A catalytic subunit beta; OTTHUMP00000225455; protein phosphatase 2A catalytic subunit, beta isoform; serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PPP2CB Related Research Area
PPP2CB involved in several pathways and played different roles in them. We selected most pathways PPP2CB participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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mRNA surveillance pathway | WDR82;PPP2CB;PNN;PABPN1L;PABPC1L;PPP2R5C;SMG6;SRRM1;CASC3 |
Sphingolipid signaling pathway | PIK3CG;RAF1;PPP2R5A;PLD1;PPP2R5C;PLD2;RHOA;GNAI1;TRADD |
Oocyte meiosis | CTH1;FBXO43;PPP1CAB;SMC1AL;PPP2R5EA;REC8;PPP2R5C;PPP2R5EB;YWHAQB |
PIK-Akt signaling pathway | TLR2;YWHAE;FGF8;Il6ra;RHEB;FOXO3;IBSP;GNG8;NGFR |
AMPK signaling pathway | LEPR;IRS2;FBP2;PRKAA2;CPT1B;EEF2;CCNA1;PPP2R5C;CREB5 |
Adrenergic signaling in cardiomyocytes | AKT2;ADRB3B;ADCY3;CAMK2B;PIK3CB;ATP1A4;ATF2;PLCB1;CACNG1A |
TGF-beta signaling pathway | PPP2CB;NODAL;RHOAA;BMP4;AMH;THBS1;ROCK2B;SMAD7;BMPR1BB |
Hippo signaling pathway | FZD1;STK3;GSK3B;APC;WWC1;PPP2R1A;WNT4;TEAD4;DLG3 |
Tight junction | ACTB;PRKCG;PPP2R1B;CRB3;PRKCD;MAGI1;ACTN2;MYH10;YES1 |
Dopaminergic synapse | AKT2;MAPK12;PLCB1;PPP2R2B;GNB2;TH;PPP2R1A;PLCB2;PRKACB |
Long-term depression | GUCY1A3;GNAQ;PRKCB;PLA2G4A;GNA11;PLA2G4D;HRAS;GRIA1;GRIA2 |
Chagas disease (American trypanosomiasis) | CCL3L3;PIK3CG;GNAI1;SMAD2;SERPINE1;C1QA;TGFBR2;IRAK1;PPP2R2C |
Hepatitis C | GRB2;IFNA17;CLDN22;PPP2R2D;IKBKB;IFNA5;PPP2R2A;EIF2AK4;IL-8 |
PPP2CB has several biochemical functions, for example, metal ion binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2CB itself. We selected most functions PPP2CB had, and list some proteins which have the same functions with PPP2CB. You can find most of the proteins on our site.
Function | Related Protein |
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metal ion binding | PDE7B;CELA1;PRKCHA;G2E3;ZFP36L2;XPNPEP2;ATP1A1A.1;DMRT3A;GALNT7 |
protein C-terminus binding | RAD51;DBNL;DLG3;FOXN3;TAE1;VPS4A;HSPB7;CDK7;ATXN2 |
protein binding | CAPN3;IQUB;RDM1;RNF41;FANCG;TIMM23;FAM133A;SH3RF2;ERCC8 |
contributes_to protein serine/threonine phosphatase activity | PPP2CB;CYCS |
PPP2CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2CB.
PPP2R1A; IGBP1; AXIN2; TCP1; CCT6A
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