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PTPN3

Official Full Name

protein tyrosine phosphatase, non-receptor type 3
Overview

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

PTPN3; protein tyrosine phosphatase, non-receptor type 3; tyrosine-protein phosphatase non-receptor type 3; PTPH1; protein-tyrosine phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase; PTP-H1; DKFZp686N0569;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PTPN3-8090H	Recombinant Human PTPN3 protein, His & T7-tagged	E.coli	His/T7	Ser18~Leu259 (Accession # P26045)	Inquiry
Human	PTPN3-2683HCL	Recombinant Human PTPN3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PTPN3-3954H	Recombinant Human PTPN3 protein, His-tagged	E.coli	His	308-508 aa	$319 / 25ug
Mouse	PTPN3-13685M	Recombinant Mouse PTPN3 Protein	Mammalian Cell	His		Inquiry
Mouse	Ptpn3-8091M	Recombinant Mouse Ptpn3 protein, His & T7-tagged	E.coli	His/T7	Glu704~Leu906 (Accession # A2ALK8)	Inquiry
Mouse	PTPN3-7281M	Recombinant Mouse PTPN3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PTPN3-7281M-B	Recombinant Mouse PTPN3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

PTPN3 involved in several pathways and played different roles in them. We selected most pathways PTPN3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PTPN3 has several biochemical functions, for example, ATPase binding, cytoskeletal protein binding, phosphotyrosine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN3 itself. We selected most functions PTPN3 had, and list some proteins which have the same functions with PTPN3. You can find most of the proteins on our site.

Function	Related Protein
ATPase binding	RALB;Ar;SELS;FBL;ATXN3;DRD1A;DNAJB1;NHP2L1;PTPN3
cytoskeletal protein binding	PKD2L1;SLC8A1;PDLIM3;FRMD5;MYLIP;NEBL;PACSIN3;PTPN4;FARP2
phosphotyrosine binding	PTPN3;ACP2;CBL;SHC1;GRB2;LDLRAP1;MAPK1;STAP1;MAPK3
protein binding	PPP2R2C;CLIC3;IKBKE;SEPT7;SSX2;IGF1R;RFX3;GZMA;CALM1
protein tyrosine phosphatase activity	CDC25B;UBASH3B;PTPRQ;PTPN20;PTENB;MTMR1;PALD1;PALD1B;SSH2
sodium channel regulator activity	SCN2B;FXYD2;PTPN3;CAV3;SCN3B;SGK2A;TMPRSS3;AGT;SCLT1

PTPN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN3.

GHR; YWHAG; LMO1; YWHAB; AKR1C1; DIP2A; ZCCHC10