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SCN1B

  • Official Full Name

    sodium channel, voltage-gated, type I, beta subunit

  • Overview

    SCN1B is a single-pass type I membrane protein abundantly expressed in skeletal muscle, heart and brain. The SCN1B forms part of a heterotrimeric complex of voltage-gated sodium channels involved in the generation and propagation of action potentials in m
  • Synonyms

    SCN1B; sodium channel, voltage-gated, type I, beta subunit; sodium channel, voltage gated, type I, beta , sodium channel, voltage gated, type I, beta polypeptide; sodium channel subunit beta-1; sodium channel beta-1 subunit; GEFSP1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SCN1B-2535H Recombinant Human SCN1B, GST-tagged E.coli GST C-term-186aa
Human SCN1B-2031HCL Recombinant Human SCN1B 293 Cell Lysate HEK293 N/A
Human SCN1B-48H Recombinant Human SCN1B Protein, GST-tagged Wheat Germ GST
Human SCN1B-6782HF Recombinant Full Length Human SCN1B Protein, GST-tagged In Vitro Cell Free System GST 218 amino acids
Mouse SCN1B-14754M Recombinant Mouse SCN1B Protein Mammalian Cell His
Mouse SCN1B-7938M Recombinant Mouse SCN1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SCN1B-7938M-B Recombinant Mouse SCN1B Protein Pre-coupled Magnetic Beads HEK293
Rat SCN1B-5261R Recombinant Rat SCN1B Protein Mammalian Cell His
Rat SCN1B-4920R Recombinant Rat SCN1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SCN1B-4920R-B Recombinant Rat SCN1B Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL9555MF Recombinant Full Length Mouse Sodium Channel Subunit Beta-1(Scn1B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-218)
Oryctolagus cuniculus (Rabbit) RFL9910OF Recombinant Full Length Rabbit Sodium Channel Subunit Beta-1(Scn1B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-218)
Pan troglodytes (Chimpanzee) RFL2056PF Recombinant Full Length Pan Troglodytes Sodium Channel Subunit Beta-1(Scn1B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-218)
Rhesus Macaque SCN1B-4099R Recombinant Rhesus monkey SCN1B Protein, His-tagged Mammalian Cell His
Rhesus Macaque SCN1B-3916R-B Recombinant Rhesus Macaque SCN1B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SCN1B-3916R Recombinant Rhesus Macaque SCN1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SCN1B Related Articles

SCN1B involved in several pathways and played different roles in them. We selected most pathways SCN1B participated on our site, such as Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCN1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adrenergic signaling in cardiomyocytesPPP1CB;CALM4;CREB5;ATF6B;SCN5A;CAMK2G1;ATP1B3A;MAPK14A;RYR2

SCN1B has several biochemical functions, for example, sodium channel inhibitor activity, sodium channel regulator activity, voltage-gated sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCN1B itself. We selected most functions SCN1B had, and list some proteins which have the same functions with SCN1B. You can find most of the proteins on our site.

Function Related Protein
sodium channel inhibitor activityNEDD4;PCSK9;CAMK2D;SCN1B;SLC14A2;NEDD4L
sodium channel regulator activityGPD1L;TMPRSS3;NOS1;AGT;SGK1;SGK2A;SCN1B;YWHAH;PKP2
voltage-gated sodium channel activitySCN1A;SCN1LAB;SCN12AA;SCN2A;SCN12AB;ASIC4A;SCN1BB;SCN8AA;SCN3B
voltage-gated sodium channel activity involved in Purkinje myocyte action potentialSCN1B;SCN5A
voltage-gated sodium channel activity involved in cardiac muscle cell action potentialSCN3B;SCN1B;SCN2B;SCN5A

SCN1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCN1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SCN1B.

Casini, S; Tan, HL; et al. Tubulin polymerization modifies cardiac sodium channel expression and gating. CARDIOVASCULAR RESEARCH 85:691-700(2010).
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