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SH2B2

Official Full Name

SH2B adaptor protein 2
Overview

APS is an SH2 and PH domain-containing adaptor protein closely related to Lnk and SH2-B. APS was identified as a substrate for many receptor tyrosine kinases including TrkA, insulin receptor, c-Kit and PDGF receptor. Tyrosine phosphorylation of APS provid
Synonyms

SH2B2; SH2B adaptor protein 2; SH2B adapter protein 2; adaptor protein with pleckstrin homology and src; APS; SH2 and PH domain-containing adapter protein APS; adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleck;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Guinea pig
Human
Mouse
Rat

Source

E.Coli or Yeast
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	APS-730H	Recombinant Human APS protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	SH2B2-1341H	Recombinant Human SH2B2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	SH2B2-15052M	Recombinant Mouse SH2B2 Protein	Mammalian Cell	His		Inquiry
Mouse	SH2B2-8114M	Recombinant Mouse SH2B2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Sh2b2-5833M	Recombinant Mouse Sh2b2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	SH2B2-8114M-B	Recombinant Mouse SH2B2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	SH2B2-5372R	Recombinant Rat SH2B2 Protein	Mammalian Cell	His		Inquiry
Rat	SH2B2-5031R	Recombinant Rat SH2B2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SH2B2-5031R-B	Recombinant Rat SH2B2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Guinea pig	Sh2b2-3307C	Recombinant Cavia porcellus (Guinea pig) Sh2b2, His-tagged	E.Coli or Yeast	His	405	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SH2B2 involved in several pathways and played different roles in them. We selected most pathways SH2B2 participated on our site, such as Neurotrophin signaling pathway, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neurotrophin signaling pathway	NFKB1;RPS6KA1;PLCG1;PSEN2;RPS6KA2;PIK3R2;IRS1;KRAS;NFKBIB
Insulin signaling pathway	ARAF;CBLB;PPP1R3D;CALM;RPS6KB1;MAP2K2;PHKG1;PPP1R3C;PHKG1B

SH2B2 has several biochemical functions, for example, JAK pathway signal transduction adaptor activity, SH3/SH2 adaptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2B2 itself. We selected most functions SH2B2 had, and list some proteins which have the same functions with SH2B2. You can find most of the proteins on our site.

Function	Related Protein
JAK pathway signal transduction adaptor activity	SH2B2;SOCS2
SH3/SH2 adaptor activity	SKAP1;SH2D3A;SKAP2;GRB7;HSH2D;NCK2;ITSN2;CHN1;EPS8
identical protein binding	VIM;DCTPP1;VWA2;OAT;MCM10;BNIPL;PRKAB2;IFI16;NONO
protein binding	ORC3L;FLVCR1;WDFY2;SNX3;ZNF238;SDC2;CITED2;FBP1;TBCA
signal transducer activity	TAAR10A;TAAR8C;OLFR488;RERG;NFKBIB;OPN1MW1;GRM8B;GNA11A;TAAR6
signaling adaptor activity	SH2B3;HOMER1;SH2B2;LDLRAP1;MPP7;GNB2L1;SH2B1;AFAP1L2
transmembrane receptor protein tyrosine kinase adaptor activity	DOK2;IRS1;SHC1;SH2B2;GAB2;FRS2;STAP1;TRAT1;PIK3R1

SH2B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2B2.

Fgfr3

Research Area

de Boer, YS; van Gerven, NMF; et al. Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1. GASTROENTEROLOGY 147:443-+(2014).

Perez-Garcia, A; Ambesi-Impiombato, A; et al. Genetic loss of SH2B3 in acute lymphoblastic leukemia. BLOOD 122:2425-2432(2013).