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SHMT2

Official Full Name

serine hydroxymethyltransferase 2 (mitochondrial)
Overview

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.
Synonyms

SHMT2; serine hydroxymethyltransferase 2 (mitochondrial); SHMT; serine hydroxymethyltransferase, mitochondrial; GLYA; Glycine hydroxymethyltransferase; Serine hydroxymethyltransferase mitochondrial; Serine methylase; SHMT 2; GLY A+; serine aldolase; threonine aldolase; serine hydroxymethylase; glycine auxotroph A, human complement for hamster;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
N/A
N
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SHMT2-927H	Recombinant Human SHMT2 Protein, His-tagged	E.coli	His		Inquiry
Human	SHMT2-31356TH	Recombinant Human SHMT2, His-tagged	E.coli	His		Inquiry
Human	SHMT2-2662H	Recombinant Human SHMT2, GST-tagged	E.coli	GST	C-term-300aa	$319 / 25ug
Human	SHMT2-1853HCL	Recombinant Human SHMT2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SHMT2-0225H	Recombinant Human SHMT2 Protein (S29-H504), His tagged	E.coli	His	S29-H504	Inquiry
Human	SHMT2-6286H	Recombinant Human SHMT2 Protein (Asn30-His504), N-His tagged	E.coli	N-His	Asn30-His504	Inquiry
Human	SHMT2-0224H	Recombinant Human SHMT2 Protein (S29-H504), Tag Free	E.coli	No tag	S29-H504	Inquiry
Zebrafish	SHMT2-6698Z	Recombinant Zebrafish SHMT2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SHMT2 Related Articles

SHMT2 involved in several pathways and played different roles in them. We selected most pathways SHMT2 participated on our site, such as Glycine, serine and threonine metabolism, Cyanoamino acid metabolism, Glyoxylate and dicarboxylate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycine, serine and threonine metabolism	SDS;PHGDH;DLDH;ALDH7A1;SRR;CBSB;GCSHB;AGXTA;ALAS2
Cyanoamino acid metabolism	GGT5A;SHMT2;GGT7;GGT1;GGT6;SHMT1;GGT5;GGT1A;GBA3
Glyoxylate and dicarboxylate metabolism	GLULA;DHDPSL;GRHPRB;SHMT2;DLDH;HOGA1;MCEE;CS;GRHPRA
One carbon pool by folate	FTCD;ALDH1L1;MTHFR;MTHFD2;DHFRL1;ST20-MTHFS;TYMS;ALDH1L2;MTHFD2L
Metabolic pathways	PPAP2C;ALG5;MGAT3;C1GALT1;GAD1;AKR1B7;CMPK1;GK;HMGCR
Carbon metabolism	FH;PCCA;ALDOB;GOT2A;PSPH;GPT;HK3;MDH1;GPIB
Biosynthesis of amino acids	GOT1;PGK2;CTH;PGAM1B;MAT1A;PFKMA;PRPS1B;PFKP;GPT

SHMT2 has several biochemical functions, for example, L-allo-threonine aldolase activity, amino acid binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHMT2 itself. We selected most functions SHMT2 had, and list some proteins which have the same functions with SHMT2. You can find most of the proteins on our site.

Function	Related Protein
L-allo-threonine aldolase activity	SHMT2;THA1;SHMT1
amino acid binding	SHMT2;TPH1A;TPH2;AGXT;PAH;DDC;TDO2;GOT2;DDAH1
chromatin binding	CBFA2T3;TCF7L1B;PELP1;NOC2L;TPR;GATA4;MPO;GABPA;FOS
glycine hydroxymethyltransferase activity	SHMT1;SHMT2
identical protein binding	RELA;CIDEB;EWSR1;DNMT3A;PARK7;ATG101;PRPS2;USP2;MAP3K11
protein binding	SEC14L4;BID;POLRMT;ECHS1;RNF126;TRIM59;PRDM14;ATP5A1;KDM2B
pyridoxal phosphate binding	TAT;SPTLC1;CSAD;SPTLC2A;LOC650128;PDXDC2P;PDXDC1;MARC1;MARC2

SHMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHMT2.

ARL6IP1; CMTM5; DEGS1; EIF1B; HLA-B; BRCC3; EIF6; GNAS; IKBKE; TRMT10C; NDRG1; DDA1; UBA5; BABAM1; BRE; TNFRSF10D

Prasannan, P; Appling, DR; et al. Human mitochondrial C(1)-tetrahydrofolate synthase: Submitochondrial localization of the full-length enzyme and characterization of a short isoform. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 481:86-93(2009).

Chen, LF; Chan, SY; et al. Distribution of folate derivatives and enzymes for synthesis of 10-formyltetrahydrofolate in cytosolic and mitochondrial fractions of pea leaves. PLANT PHYSIOLOGY 115:299-309(1997).