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SLC18A1

Official Full Name

solute carrier family 18 (vesicular monoamine), member 1
Overview

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient;maintained across the vesicular membrane. Its proper function is essential to the correct activity of the;monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site;of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 (PubMed 7905859)). See also;SLC18A2 (MIM 193001).
Synonyms

SLC18A1; solute carrier family 18 (vesicular monoamine), member 1; VAT1, VMAT1; chromaffin granule amine transporter; CGAT; 4832416I10Rik; Adrenal chromaffin granule amine transporter; MGC28683; MGC37299; Solute carrier family 18 member 1; VAT 1; VAT1; Vesicular amine transporter 1; VMAT 1; VMAT1_HUMAN; OTTHUMP00000122508; OTTHUMP00000224712; OTTHUMP00000224713; OTTHUMP00000224714; OTTHUMP00000237226; VMAT1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC18A1-29829TH	Recombinant Human SLC18A1	Wheat Germ	N/A	494 amino acids	Inquiry
Human	SLC18A1-371H	Recombinant Human SLC18A1	Mammalian Cell	His		Inquiry
Human	SLC18A1-2702H	Recombinant Human SLC18A1, GST-tagged	E.coli	GST	43-138aa	$319 / 25ug
Human	SLC18A1-487HF	Recombinant Full Length Human SLC18A1 Protein	In Vitro Cell Free System		494 amino acids	Inquiry
Human	SLC18A1-4067H	Recombinant Human SLC18A1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	SLC18A1-4067H-B	Recombinant Human SLC18A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SLC18A1 involved in several pathways and played different roles in them. We selected most pathways SLC18A1 participated on our site, such as Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC18A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Synaptic vesicle cycle	STX3;UNC13A;ATP6V0D2;SLC18A2;ATP6V1A;NSF;STX1A;ATP6V0A1;CPLX2
Serotonergic synapse	APP;ALOX12;PLCB3;PRKCG;NRAS;PLA2G4F;HTR3B;ALOX12B;GNAI2
Dopaminergic synapse	CALM2;KIF5B;KIF5A;GNG12;PPP1CB;DRD5;DRD1;GRIA4;GNGT1
Parkinsons disease	COX7A2L;NDUFA12;NDUFA4;NDUFC2;NDUFB3;NDUFB6;ATP5O;NDUFA11;NDUFB9
Cocaine addiction	GRM3;DRD1;GRIA2;MAOA;GNAS;GPSM1;PRKACA;GRIN2A;CDK5
Alcoholism	GNB3;HIST1H2BC;GM14478;BDNF;MAOB;GNG8;NPY;HIST1H2AC;CREB3L1

SLC18A1 has several biochemical functions, for example, drug transmembrane transporter activity, enzyme binding, monoamine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC18A1 itself. We selected most functions SLC18A1 had, and list some proteins which have the same functions with SLC18A1. You can find most of the proteins on our site.

Function	Related Protein
drug transmembrane transporter activity	ABCG2A;Abcb1b;ABCG3;SLC47A1;ABCG2D;SLCO1B2;SLC17A3;EBP;SLC22A5
enzyme binding	PRKDC;USP22;POR;TAF10;TH;TRIO;TGFB1;MSH3;GSTM3
monoamine transmembrane transporter activity	SLC22A1;SLC18A1;SLC6A4;SLC29A4;SLC6A3;SLC6A2;SLC18A2
serotonin transmembrane transporter activity	SLC6A4A;SLC6A4B;SLC6A4;SLC18A1

SLC18A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC18A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC18A1.

Research Area

Ashe, KM; Chiu, WL; et al. Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. NEUROENDOCRINOLOGY LETTERS 32:253-258(2011).