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SLK

Official Full Name

STE20-like kinase
Overview

SLK and induces apoptosis in cultured fibroblasts. Over-expression of SLK in various cell lines induces rapid disassembly of actin stress fibers and cell death. Relatively high levels of SLK protein and activity have been observed in all cell types analyzed, suggesting a functional role for SLK in physiological processes other than apoptosis. Activity of SLK is also increased during progression through the G2 phase of the mammalian cell cycle and may function as a regulator of Plk during the somatic cell cycle. The activity of SLK is regulated by phosphorylation and its expression is down-regulated upon mitogen depletion of myoblast and fibroblast cultures.
Synonyms

SLK; STE20-like kinase; SNF1 (sucrose nonfermenting, yeast, homolog) like kinase, SNF1 sucrose nonfermenting like kinase (yeast) , STE20 like kinase (yeast); STE20-like serine/threonine-protein kinase; KIAA0204; se20 9; STK2; hSLK; STE20-related kinase; Long Ste20-like Kinase; CTCL tumor antigen se20-9; serine/threonine-protein kinase 2; Ste20-related serine/threonine kinase; SNF1 sucrose nonfermenting like kinase; STE20-related serine/threonine-protein kinase; SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase; LOSK; se20-9; bA16H23.1; MGC133067;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Pan paniscus
Rat

Source

HEK293
Insect (sf21)
Insect Cell
Mammalian Cell
Sf9 Insect Cell

Tag

GST
His
His (Fc)
Avi
N/A
No tag
Tag Free

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLK-30443TH	Recombinant Human SLK		N/A		Inquiry
Human	SLK-432H	Recombinant Human STE20-like Kinase (Yeast), GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	SLK-1681HCL	Recombinant Human SLK 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SLK-0658H	Recombinant Human SLK Protein (M1-T1152), GST tagged	Insect Cell	GST	M1-T1152	Inquiry
Human	SLK-8902HF	Active Recombinant Full Length Human SLK Protein, GST-tagged	Insect (sf21)	GST	1-1152	Inquiry
Human	SLK-0659H	Recombinant Human SLK Protein (M1-T1152), Tag Free	Insect Cell	No tag	M1-T1152	Inquiry
Rat	SLK-5603R	Recombinant Rat SLK Protein	Mammalian Cell	His		Inquiry
Rat	SLK-5262R	Recombinant Rat SLK Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SLK-5262R-B	Recombinant Rat SLK Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Pan paniscus	SLK-1354P	Recombinant Pan paniscus SLK Protein (M1-T1152), GST-tagged	Insect Cell	GST	M1-T1152	Inquiry
Pan paniscus	SLK-1355P	Recombinant Pan paniscus SLK Protein (M1-T1152)	Insect Cell	Tag Free	M1-T1152	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLK Related Articles

SLK involved in several pathways and played different roles in them. We selected most pathways SLK participated on our site, such as Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oocyte meiosis	YWHAG1;SLK;PPP2R5C;CAMK2D2;CPEB1B;CAMK2B1;RPS6KA1;PTTG1;RBX1

SLK has several biochemical functions, for example, ATP binding, identical protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLK itself. We selected most functions SLK had, and list some proteins which have the same functions with SLK. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CCT2;HSPA2;MYH7;FBXO18;CHEK2;NAIP6;PRKG1;DDX10;AURKB
identical protein binding	TRIM5;NISCH;TMEM115;SERPINA1D;PIK3AP1;SUN2;AIRE;SELK;SIAH1
protein homodimerization activity	ADAM10;CRYM;TFRC;RAB11FIP4;PRTFDC1;PEX11A;SLC30A8;BOKB;RAB11FIP3
protein serine/threonine kinase activity	STK32A;PRKACAA;TESK2;DCLK3;MAP3K9;MAPK8;SNRKA;MAPK14B;MAPK8B

SLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLK here. Most of them are supplied by our site. Hope this information will be useful for your research of SLK.

KEAP1; IKBKE; CLSTN1; rpoB; q7cl54_yerpe; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; bosutinib; imatinib; purvalanol b; crizotinib; GABARAP

Leca, N; Warner, P; et al. Outcomes of Simultaneous Liver and Kidney Transplantation in Relation to a High Level of Preformed Donor-Specific Antibodies. TRANSPLANTATION 96:914-918(2013).

Kressel, A; Therapondos, G; et al. Excellent liver retransplantation outcomes in hepatitis C-infected recipients. CLINICAL TRANSPLANTATION 27:E512-E520(2013).