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SP100

Official Full Name

SP100 nuclear antigen
Overview

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Synonyms

SP100; SP100 nuclear antigen; lysp100b; nuclear autoantigen Sp-100; speckled 100 kDa; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Rat

Source

E.coli
In Vitro Cell Free System
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SP100-462H	Recombinant Human SP100 Protein, His-tagged	E.coli	His	Gly610~Lys802	Inquiry
Human	SP100-30989TH	Recombinant Human SP100	Wheat Germ	N/A	98 amino acids	Inquiry
Human	SP100-30988TH	Recombinant Human SP100	Wheat Germ	N/A	480 amino acids	Inquiry
Human	SP100-201H	Recombinant Human SP100 Protein, GST-tagged	E.coli	GST	700-876	Inquiry
Human	SP100-202H	Recombinant Human SP100 Protein, His-tagged	E.coli	His	700-876	Inquiry
Human	SP100-1674HCL	Recombinant Human SP100 cell lysate		N/A		Inquiry
Human	SP100-488HF	Recombinant Full Length Human SP100 Protein	In Vitro Cell Free System		480 amino acids	Inquiry
Mouse	Sp100-463M	Recombinant Mouse Sp100 Protein, His-tagged	E.coli	His	Thr261~Lys465	Inquiry
Rat	Sp100-464R	Recombinant Rat Sp100 Protein, His-tagged	E.coli	His	Phe116~Pro333	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SP100 Related Articles

SP100 involved in several pathways and played different roles in them. We selected most pathways SP100 participated on our site, such as Herpes simplex infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP100 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Herpes simplex infection	HLA-DOB;MED8;TAF9B;CLOCK;HLA-DRA;SRSF2B;PPP1CAA;STAT2;TNFRSF14
Viral carcinogenesis	HLA-F;YWHAB;CREB3L1;GTF2B;HIST1H2BI;HDAC3;HRAS;MAPK1;NFKBIA

SP100 has several biochemical functions, for example, DNA binding, chromatin binding, chromo shadow domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP100 itself. We selected most functions SP100 had, and list some proteins which have the same functions with SP100. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	FBXL19;PBX1B;MYC;PRM1;HMGA1B;HIST1H4H;ZBTB6;SPI1B;GTF2IRD2
chromatin binding	JUN;ESR1;HOXD13;UXT;PHC1;ZKSCAN3;TOP1;HHEX;ARNTL1B
chromo shadow domain binding	TRIM28;ATRX;NIPBL;CHAF1A;LBR;SP100
cytokine activity	TGFB3;TIMP1;INHBC;TNFSF18;BMP2B;TGFB2;FAM3D;GDF6B;GM13289
identical protein binding	STAC3;EDC3;CHMP4A;HOOK2;SHANK1;DLC;TRIM21;PTS;HSD17B10
kinase binding	PARK2;PFKM;PIP5K1A;WWC2;RB1;DLG3;BARD1;PFKL;STUB1
protein binding	DLL1;APBB1IP;RG9MTD1;PRSS2;SH2B2;STXBP2;UBR2;SFN;ZNF490
protein domain specific binding	ODF1;HAND2;ARHGEF4;DDC;RAPGEF3;SERPINB1A;SORBS2;TACC2;MRPS31
protein homodimerization activity	HMGCS1;NKX2;ANO2;SMAGP;CUL3;CCBL1;CRYBB2;QPRT;BCL2A1A
transcription coactivator activity	PPARGC1A;NFE2;TADA2B;LPIN1;TRIM24;SP100;MMS19;TFDP1B;SUPT3H
transcription corepressor activity	NAB2;NR0B2A;AJUBA;DDX54;ANKRD1;ZFPM2;TRIM28;POU1F1;TGIF1
transcription factor binding	NFATC4;NR0B2;MED6;FOXO4;BCL3;NFATC2;TAF1;DAXX;STK36

SP100 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP100 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP100.

SUMO1; UL123; CASP8AP2; ACTN2

Norman, GL; Yang, CY; et al. Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis. LIVER INTERNATIONAL 35:642-651(2015).

Villalta, D; Sorrentino, MC; et al. Autoantibody profiling of patients with primary biliary cirrhosis using a multiplexed line-blot assay. CLINICA CHIMICA ACTA 438:135-138(2015).