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Official Full Name
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1;;MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding;both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase;activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and;Masison, 2005 (PubMed 16100115)).
STIP1; stress-induced phosphoprotein 1; stress-induced-phosphoprotein 1; mSTI1; IEF SSP 3521; stress-inducible protein; Hsp70/Hsp90 organizing protein; hsc70/Hsp90-organizing protein; Hop; p60; Sti1