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TAP1

Official Full Name

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Overview

CRTAP is found in articular chondrocytes and is expressed in a variety of other tissues. Defects in CRTAP are the cause of osteogenesis imperfecta type 7 (OI-7). OI is a connective tissue disorder characterized by bone fragility and low bone mass. OI-7 is an autosomal recessive form of OI.
Synonyms

TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); APT1; PSF1; ABC17; ABCB2; RING4; TAP1N; D6S114E; FLJ26666; FLJ41500; TAP1*0102N; ABC 17; ATP binding cassette sub family B (MDR/TAP) member 2; ATP binding cassette transporter; Peptide transporter PSF 1; Transporter 1 ATP binding cassette sub family B (MDR/TAP); Peptide supply factor 1; Really interesting new gene 4 protein2; PSF-1; antigen peptide transporter 1; ABC transporter, MHC 1; transporter, ATP-binding cassette, major histocompatibility complex, 1Y3; transporter associated with antigen processing;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Rat

Source

E.coli
E.Coli or Yeast
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TAP1-7882H	Recombinant Human TAP1 protein, His & T7-tagged	E.coli	His/T7	Tyr525~Glu808 (Accession # Q03518)	Inquiry
Human	TAP1-3512H	Recombinant Human TAP1, His-tagged	E.Coli or Yeast	His	808	Inquiry
Human	TAP1-3113H	Recombinant Human TAP1, GST-tagged	E.coli	GST	C-term-300aa	$319 / 25ug
Human	TAP1-1254HCL	Recombinant Human TAP1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TAP1-6821HF	Recombinant Full Length Human TAP1 Protein, GST-tagged	In Vitro Cell Free System	GST	808 amino acids	Inquiry
Human	TAP1-6397H	Recombinant Human TAP1 Protein (Tyr525-Glu808), N-His tagged	E.coli	N-His	Tyr525-Glu808	Inquiry
Human	TAP1-675H	Recombinant Human TAP1 Protein, GST-tagged	Wheat Germ	GST	1-808 aa	Inquiry
Rat	Tap1-3511R	Recombinant Rat Tap1, His-tagged	E.Coli or Yeast	His	725	Inquiry
Chicken	TAP1-3878C	Recombinant Chicken TAP1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TAP1 Related Articles

TAP1 involved in several pathways and played different roles in them. We selected most pathways TAP1 participated on our site, such as ABC transporters, Phagosome, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ABC transporters	ABCB6A;ABCC11;ABCA8;ABCC10;ABCA1B;ABCG2;ABCD2;Abcb1b;ABCD1
Phagosome	HLA-DRA;TLR2;HLA-DMA;ATP6V1G2;HLA-DPA1;FCAR;MRC1;CD36;CD209
Antigen processing and presentation	KLRD1;CTSB;RFX5;H2-AA;HSP90AA1;HLA-DRB4;KIR2DS5;HLA-DPB1;HSPA1B
Herpes simplex infection	MAPK9;SRSF7;CLOCK;PPP1CA;TAF9B;TLR2;SRSF2;C3;HLA-E
Primary i	CD3D;CD8B1;RFX5;TAP1;CD8B;IGLL1;ORAI1;LCK;AIRE
nodeficiency	CD8A;UNG;IKBKG;IGLL1;RFX5;AIRE;PTPRC;CD40LG;ORAI1

TAP1 has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by TAP1 itself. We selected most functions TAP1 had, and list some proteins which have the same functions with TAP1. You can find most of the proteins on our site.

Function	Related Protein
ADP binding	PRKAG2;CYB5R3;VCP;MYO6;MYO9B;ACTA1;TAP1;ADCK3;APAF1
ATP binding	ABCB8;FLT4;CKB;MAPK4;PRKG2;HARS;MAP4K2;STK35;LANCL2
ATPase activity, coupled to transmembrane movement of substances	ABCA13;ABCB8;ABCC9;ABCG8;ABCC5;ABCB7;ABCD2;DPY19L2;ABCA5
MHC class I protein binding	HLA-E;CD8B;TAP1;ATP5B;LILRB2;PILRB2;PILRB;DERL1;BCAP31
MHC class Ib protein binding	LILRB2;TAP1;TAP2
TAP1 binding	TAPBP;TAP1;TAP2;HLA-F
TAP2 binding	HLA-F;TAP1;TAPBP
peptide antigen binding	H2-AA;MHC1UXA2;MHC1ZBA;MHC1UFA;BF2;HLA-E;HLA-A;HLA-DRA;MHC1UIA
contributes_to peptide transporter activity	TAP2;TAP1
peptide transporter activity	TAP1;DISP1
peptide-transporting ATPase activity	ABCB9;TAP1
protein binding	PCDH17;OPRD1;KIAA0141;EMG1;IFT20;KLRK1;HNF4A;CCDC130;ATP6V1D
protein heterodimerization activity	FLOT1;HIST1H2AI;TLR6;ADIPOR1;HIST1H4H;BAD;LIFR;DMRT1;TAF11
protein homodimerization activity	S100A1;VPS4B;BOKA;BHLHE40;TGFB2;TFAP2A;JAM3;TIMM9;MCL1
tapasin binding	TAP2;TAP1

TAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAP1.

TAP2; TAPBP

Tuncel, J; Haag, S; et al. Natural Polymorphisms in Tap2 Influence Negative Selection and CD4 : CD8 Lineage Commitment in the Rat. PLOS GENETICS 10:-(2014).

Gameiro, SR; Jammeh, ML; et al. Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing. ONCOTARGET 5:403-416(2014).