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TCTN2

Official Full Name

tectonic family member 2
Overview

This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

TCTN2; tectonic family member 2; C12orf38, chromosome 12 open reading frame 38; tectonic-2; FLJ12975; Meckel syndrome; type 8; MKS8; TECT2; C12orf38;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TCTN2-3168H	Recombinant Human TCTN2, His-tagged	E.coli	His	351-697aa	$319 / 25ug
Human	TCTN2-1159HCL	Recombinant Human TCTN2 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	TCTN2-16596M	Recombinant Mouse TCTN2 Protein	Mammalian Cell	His		Inquiry
Mouse	Tctn2-1417M	Recombinant Mouse Tctn2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	TCTN2-9099M-B	Recombinant Mouse TCTN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	TCTN2-9099M	Recombinant Mouse TCTN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	TCTN2-5996R	Recombinant Rat TCTN2 Protein	Mammalian Cell	His		Inquiry
Rat	TCTN2-5655R	Recombinant Rat TCTN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	TCTN2-5655R-B	Recombinant Rat TCTN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
TCTN2 Related Articles

TCTN2 involved in several pathways and played different roles in them. We selected most pathways TCTN2 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, G2/M Transition, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	TCTN2;YWHAB;HAUS2;GINS4;SSNA1;GORASP1;MCM6L;STIL;TMPO
Cell Cycle, Mitotic	SMC4;SKA2;KIF2A;DYNC1H1;CKAP5;SMC2;GINS2;POLD3;CLASP1A
G2/M Transition	CEP70;OFD1;FOXM1;DCTN3;ODF2;CCP110;NEDD1;CEP63;CEP290
Mitotic G2-G2/M phases	CDK11B;TUBGCP4;TUBG2;TCTN2;TUBGCP2;BORA;NUMA1;LIN37;TUBGCP5
PLK1 signaling events	BORA;NDC80;ERCC6L;TPT1;ECT2;PLK1S1;TPX2;TCTN2;SPC24
Regulation of PLK1 Activity at G2/M Transition	BORA;TCTN2

TCTN2 has several biochemical functions, for example, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCTN2 itself. We selected most functions TCTN2 had, and list some proteins which have the same functions with TCTN2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	IGF2BP1;GALNT2;DOCK2;ACTR10;TAF9B;LMX1B;STAP2;SOSTDC1B;ALOX12B
protein kinase binding	ATF2;GCSAM;THY1;LIPE;CDK5RAP1;EEF1A1;EEF2;PFKFB2;CDK5

TCTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCTN2.

Katinas, L; Crisci, JV; et al. Trans-oceanic dispersal and evolution of early composites (Asteraceae). PERSPECTIVES IN PLANT ECOLOGY EVOLUTION AND SYSTEMATICS 15:269-280(2013).

Lotfy, HI; et al. Active concomitant counterclockwise rotation and northwards translation of Africa during the Albian-Campanian time: A paleomagnetic study on the Wadi Natash alkaline volcanic province (104-78 Ma), South Eastern Desert, Egypt. PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY 310:176-190(2011).