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TTBK2

Official Full Name

tau tubulin kinase 2
Overview

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this;gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and;atrophy of the cerebellum and brainstem.
Synonyms

TTBK2; tau tubulin kinase 2; SCA11, spinocerebellar ataxia 11; tau-tubulin kinase 2; KIAA0847; SCA11; Spinocerebellar ataxia 11; TTBK; TTBK 2; TTBK2_HUMAN;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Human
Mouse

Source

E.coli
Sf21
Sf9 Insect Cell

Tag

GST
His
Myc
His|GST
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TTBK2-251H	Active Recombinant Human TTBK2(1-331) Protein, N-GST-tagged	Sf21	GST	1-331 aa	Inquiry
Human	TTBK2-1114H	Recombinant Human Tau Tubulin Kinase 2, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	TTBK2-1312H	Recombinant Human TTBK2 protein, His & GST-tagged	E.coli	His/GST	Trp21~Thr314 (Accession # Q6IQ55)	Inquiry
Human	TTBK2-1850HCL	Recombinant Human TTBK2 cell lysate		N/A		Inquiry
Human	TTBK2-4568H	Recombinant Human TTBK2 protein, His&Myc-tagged	E.coli	His&Myc	18-287aa	Inquiry
Human	TTBK2-3512H	Recombinant Human TTBK2 protein, His-tagged	E.coli	His	1-354 aa	$319 / 25ug
Mouse	TTBK2-1502M	Active Recombinant Mouse TTBK2, GST-tagged	Sf9 Insect Cell	GST	70-538 aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TTBK2 Related Articles

TTBK2 involved in several pathways and played different roles in them. We selected most pathways TTBK2 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTBK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Anchoring of the basal body to the plasma membrane	DCTN2;CCDC123;CEP78;CLASP1A;CEP72;FBF1;PLK4;CCDC41;ACTR1A
Assembly of the primary cilium	CLASP1;SDCCAG8;CNGA2;DYNC1H1;KIFAP3;OST4;RP2;RABL5;DYNLRB2
Organelle biogenesis and maintenance	SCLT1;MARK4;GABPB1;NPHP1;TMEM67;DYNLRB2;RPGRIP1L;CLUAP1;IFT81

TTBK2 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TTBK2 itself. We selected most functions TTBK2 had, and list some proteins which have the same functions with TTBK2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ACTBL2;VRK1;CSK;ATP2B3B;GTF2F2;OPLAH;CCT8;ACTR2;NTRK2B
protein binding	CRY1A;ACACA;DKC1;KRT80;NIPAL3;ADRB1;CHD8;FGFR2;RABL2A
protein serine/threonine kinase activity	ARAF;CSNK1DB;NLK1;TTK;ZAK;AKT2L;STK10;PAK2;CDC7

TTBK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTBK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TTBK2.

CEP164; KLHL12; 20555151; CRK; GABARAPL2

Bender, C; Ullrich, A; et al. PRKX, TTBK2 and RSK4 expression causes sunitinib resistance in kidney carcinoma- and melanoma-cell lines. INTERNATIONAL JOURNAL OF CANCER 131:E45-E55(2012).