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TTI1

  • Official Full Name

    TELO2 Interacting Protein 1

  • Overview

    TTI1 promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. TTI1 interacts with TELO2, MTOR, ATM, ATR, PRKDC, SMG1 and TRRAP.
  • Synonyms

    TTI1; TELO2 interacting protein 1; mg-10; KIAA0406; Tel2 interacting protein 1 homolog (S. pombe); smg-10; smg-10 homolog, nonsense mediated mRNA decay factor (C. elegans); Protein SMG10; SMG10; OTTHUMP00000030950; OTTHUMP00000030952; Tel2-interacting protein 1 homolog; smg-10 homolog, nonsense mediated mRNA decay factor;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TTI1-4977HCL Recombinant Human KIAA0406 293 Cell Lysate HEK293 N/A
Human TTI1-2924H Recombinant Human TTI1 Protein, DDK-tagged Insect Cell DDK
Mouse TTI1-17584M Recombinant Mouse TTI1 Protein Mammalian Cell His
Mouse TTI1-9734M Recombinant Mouse TTI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TTI1-9734M-B Recombinant Mouse TTI1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TTI1 Related Articles

TTI1 involved in several pathways and played different roles in them. We selected most pathways TTI1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TTI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

TTI1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTI1 itself. We selected most functions TTI1 had, and list some proteins which have the same functions with TTI1. You can find most of the proteins on our site.

Function Related Protein
protein bindingHIST1H2BI;MIF4GD;NCF4;COMP;VAT1L;POGK;ZBTB7B;HMGB1;TAPBP

TTI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TTI1.

TELO2; ATM; TTI2; SMG1

Pal, M; Morgan, M; et al. Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1. STRUCTURE 22:805-818(2014).
Rao, F; Cha, JY; et al. Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2. MOLECULAR CELL 54:119-132(2014).
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