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UBE2E1

Official Full Name

ubiquitin-conjugating enzyme E2E 1
Overview

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms

UBE2E1; ubiquitin-conjugating enzyme E2E 1; ubiquitin conjugating enzyme E2E 1 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 E1; UbcH6; UB2E1_HUMAN; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1; OTTHUMP00000161049; OTTHUMP00000161050; OTTHUMP00000208307; OTTHUMP00000208308; OTTHUMP00000208309; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5);

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Insect Cell
Mammalian Cell

Tag

C
Myc
DDK
His
His (Fc)
Avi
Strep
Myc|DDK
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UBE2E1-852H	Recombinant Human UBE2E1, None tagged	E.coli	N/A		Inquiry
Human	UBE2E1-254H	Recombinant Human UBE2E1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	UBE2E1-310H	Recombinant Human UBE2E1 Protein, His-tagged	E.coli	His		Inquiry
Human	UBE2E1-0015H	Recombinant Human UBE2E1 Protein (S2-T193), Tag Free	Insect Cell	No tag	S2-T193	Inquiry
Human	UBE2E1-174H	Recombinant Human UBE2E1 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	C-Myc/DDK		Inquiry
Human	UBE2E1-0016H	Recombinant Human UBE2E1 Protein (S2-T193), His/Strep tagged	Insect Cell	His/Strep	S2-T193	Inquiry
Mouse	UBE2E1-17712M	Recombinant Mouse UBE2E1 Protein	Mammalian Cell	His		Inquiry
Mouse	UBE2E1-9825M-B	Recombinant Mouse UBE2E1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	UBE2E1-9825M	Recombinant Mouse UBE2E1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	UBE2E1-5955Z	Recombinant Zebrafish UBE2E1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UBE2E1 Related Research Area

UBE2E1 involved in several pathways and played different roles in them. We selected most pathways UBE2E1 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ubiquitin mediated proteolysis	TCEB1B;RBX1;UBE3A;FBXW11B;SOCS1;PIAS4;CDC27;FBXW8;UBE3C
Protein processing in endoplasmic reticulum	NFE2L2;RPN2;UBE2J1;CUL1A;TRAM1;CAPN1B;UBE2E2;DNAJC3;HSPA6

UBE2E1 has several biochemical functions, for example, ATP binding, ISG15 transferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2E1 itself. We selected most functions UBE2E1 had, and list some proteins which have the same functions with UBE2E1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CAMK2B;EPB42;HARS2;TRP53;PAPOLB;FAM20C;MATK;GSK3AB;ATP1A1A.3
ISG15 transferase activity	UBE2E1;UBE2L6;UBE2E2;HERC5
protein binding	FABP2;ZFYVE20;SPI1B;PARVA;XIAP;HNF4A;RAD23B;GTF2H4;NIP7
ubiquitin conjugating enzyme activity	UBE2J1;UBE2E3;UBE2L3;UBE2H;UBE2C;UBE2J2;UBE2Q2;UBE2N;UBE2Z
ubiquitin-protein transferase activity	RCHY1;UBE2R2;MKRN1;RNF213;HECTD1;G2E3;RBBP6;CMTM2A;TRIM23

UBE2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2E1.

ZNRF1; ospG; RNF111; RNF25; RNF5; RNF167; RNF11; PAF1; UBA1; UBE2N

Histone Ubiquitylation

E2 Ubiquitin/Ubl Conjugating Enzymes