The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UBE2E1; ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast); ubiquitin-conjugating enzyme E2 E1; ubiquitin-protein ligase E1; ubiquitin carrier protein E1; ubiquitin-conjugating enzyme 5; UbcM3; Ubce5; ubcM2