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XPO1

Official Full Name

exportin 1
Overview

The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008]
Synonyms

XPO1; exportin 1; emb; CRM1; exp1; exportin-1; CRM1, yeast, homolog; exportin 1 (CRM1 homolog, yeast); chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; exportin-1 (required for chromosome region maintenance);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	XPO1-3754H	Recombinant Human XPO1, GST-tagged	Wheat Germ	GST		Inquiry
Human	XPO1-3753H	Recombinant Human XPO1, GST-tagged	E.coli	GST	N-term-302aa	$319 / 25ug
Human	XPO1-259HCL	Recombinant Human XPO1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	XPO1-5164H	Recombinant Human XPO1 Protein (Thr917-Asp1071), His tagged	E.coli	His	Thr917-Asp1071	Inquiry
Human	XPO1-460H	Recombinant Human XPO1 Protein, His-tagged	E.coli	His	Thr917~Asp1071	Inquiry
Human	XPO1-551HF	Recombinant Full Length Human XPO1 Protein, GST-tagged	In Vitro Cell Free System	GST	1071 amino acids	Inquiry
Human	XPO1-3796H	Recombinant Human XPO1 protein, His-tagged	E.coli	His	301-540 aa	$319 / 25ug
Rat	XPO1-6619R	Recombinant Rat XPO1 Protein	Mammalian Cell	His		Inquiry
Rat	XPO1-6275R-B	Recombinant Rat XPO1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	XPO1-6275R	Recombinant Rat XPO1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	XPO1-5230R	Recombinant Rhesus monkey XPO1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	XPO1-5043R-B	Recombinant Rhesus Macaque XPO1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	XPO1-5043R	Recombinant Rhesus Macaque XPO1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	XPO1-2087C	Recombinant Chicken XPO1	Mammalian Cell	His		Inquiry
Chicken	XPO1-5491C	Recombinant Chicken XPO1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

XPO1 involved in several pathways and played different roles in them. We selected most pathways XPO1 participated on our site, such as Ribosome biogenesis in eukaryotes, RNA transport, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ribosome biogenesis in eukaryotes	RIOK1;NOP58;NXF3;TBL3;NHP2L1B;NOP56;GTPBP4;WDR36;XRN1
RNA transport	RNPS1;NUP214;MAGOH2;WIBG;EIF4BA;NUP107;EIF3HA;POP7;EIF3D
Influenza A	HSPA1B;TLR3;IFIH1;TBK1;NXF3;IFNA2;HLA-DRB1;IL-8;TNFRSF1A
HTLV-I infection	FZD5;STAT5A;VDAC2;TGFB2;HLA-DMB;VAC14;FOSL1;NFYB;ITGB2L
Epstein-Barr virus infection	TYK2;GTF2E1;HSPA1L;HLA-DQA2;MAP2K4;MDM2;NCOR2;POLR2F;HSPA6

XPO1 has several biochemical functions, for example, RNA binding, Ran GTPase binding, nucleocytoplasmic transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO1 itself. We selected most functions XPO1 had, and list some proteins which have the same functions with XPO1. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	EIF4E3;NHP2L1A;RPL30;EIF4B;XPO5;OOEP;RPS25;AGO1;EIF2S2
Ran GTPase binding	DPY19L2;XPO1;XPO5;KPNB1;TNPO1;BIRC5;IPO11;NUTF2;NUP153
nucleocytoplasmic transporter activity	NUP35;NUPL1;NUP54;NUP107;NUP133;UPF3A;XPO1;NUP214;RBM22
protein binding	BAX;PTPRZ1;CLOCK;EEF1A1;SLC19A2;RBM5;GJB6;CDK4;FBXO25
protein domain specific binding	ST13;MPP7;POU2F2;TJP2;HOMER2;IRS2;ESRRA;DYNLL1;RQCD1
protein transporter activity	IPO4;VPS35;SOSTDC1B;TNPO3;RANBP6;KPNA1;KPNA4;RAB4A;RUFY1
transporter activity	RBP7B;TMEM184B;SLC2A15A;SLC15A5;TCOF1;SLC25A31;CRABP2B;RBP2A;AQP1A.2

XPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO1.

YWHAZ; VCAM1; BIRC5; vpu; TGS1; HAX1; ERBB2; TP53; RCC1