ABCG2A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Zebrafish | ABCG2A-3844Z | Recombinant Zebrafish ABCG2A | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
ABCG2A involved in several pathways and played different roles in them. We selected most pathways ABCG2A participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB11;ABCA1;ABCB3L1;ABCA13;ABCG3;ABCC4;ABCC1;ABCD2;TAP2 |
ABCG2A has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG2A itself. We selected most functions ABCG2A had, and list some proteins which have the same functions with ABCG2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PTK7;ABCF3;FICD;TOP2B;CSNK1A1L;BMPR1AB;HSP90B1;TOR2A;CDK15 |
| ATPase activity | HSPA8;KIF2C;PICK1;NSFB;ABCG4B;ABCB4;NSF;IDE;KIF13B |
| ATPase activity, coupled to transmembrane movement of substances | ABCA9;Abcb1b;DPY19L2;ABCB10;ABCA8;ABCD1;ABCC6;ABCC2;ABCB1 |
| drug transmembrane transporter activity | SLC22A5;EBP;ABCG2D;SLC47A2;SLC47A1;SLC18A1;SLC22A18;SLC18A3B;Abcb1b |
| nucleotide binding | NXF1;RAB25A;RBM24B;HIPK2;TMEM63B;MYHZ1.1;TRNAU1AP;NTRK2B;TUBB5 |
ABCG2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG2A.
- Q&As
- Reviews
Q&As (20)
Ask a questionThe intracellular concentration of chemotherapy drugs, such as mitoxantrone and topotecan, is decreased by ABCG2A.
Overexpression of ABCG2A has been observed in various cancers like breast, lung, and colon cancer.
It belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Significant activation of trout Abcg2a ATPase was observed for prazosin, doxorubicine, sildenafil, furosemid, propranolol, fenofibrate and pheophorbide.
The potential diagnostic marker value of ABCG2A expression in drug resistance is being investigated in certain cancers, but further research is necessary for clinical use.
Besides drug resistance, ABCG2A also performs other functions, including cellular toxin protection and regulation of compound absorption.
Genetic variations in ABCG2A can impact drug response and contribute to variations in drug efficacy and toxicity between individuals.
Malathione,endosulfan, chlorpyrifos, fenoxycarb and DDE could inhibite the activities of ABCG2A.
ABCG2A expression has been detected not only in cancer cells but also in normal tissues, albeit at lower levels.
Lifestyle factors like smoking and diet have been linked to altered ABCG2A expression, but additional studies are needed to establish the exact relationship.
The regulation of ABCG2A expression involves factors like genetic variations, epigenetic modifications, and signaling pathways associated with cancer and drug resistance.
ABCG2A protein are maily present in zebrafish and oncorhynchus mykiss.
In previous study, it has been cloned the full gene sequence of rainbow trout (Oncorhynchus mykiss) Abcg2a and showed its high expression in liver and primary hepatocytes.
The highest activation was obtained for benzo(a)pyrene, curcumine and testosterone
Current research focuses on understanding ABCG2A-mediated drug resistance mechanisms, developing novel inhibitors, and exploring its potential as a therapeutic target.
Although inhibiting ABCG2A enhances drug efficacy, it can also increase the risk of toxicity or adverse effects due to altered intracellular drug concentrations.
Inhibitors like fumitremorgin C and Ko143 have been identified for ABCG2A, enhancing the efficacy of specific drugs in cancer treatment.
ABCG2A is a specific variant of the ABCG2 gene responsible for drug transport and resistance.
The function of ABCG2A involves actively pumping certain drugs out of cells, leading to reduced effectiveness.
Specific drugs targeting ABCG2A are not currently available, but ongoing research aims to develop selective inhibitors to overcome drug resistance.
Customer Reviews (5)
Write a reviewIt yielded the desired functional outcomes
It delivered consistent results across multiple experiments.
Interacted exclusively with the target molecule and minimizing off-target effects.
I conducted stringent quality control tests and found the protein product to be free from contaminants.
It allowed for reproducibility and reducing experimental variability.
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