Activin AB
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | Activin AB-61H | Active Recombinant Human Activin AB | CHO | N/A |
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| Human | Activin AB-60H | Active Recombinant Human Activin AB, CF | CHO | N/A |
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Activin AB involved in several pathways and played different roles in them. We selected most pathways Activin AB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Activin AB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Activin AB has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Activin AB itself. We selected most functions Activin AB had, and list some proteins which have the same functions with Activin AB. You can find most of the proteins on our site.
| Function | Related Protein |
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Activin AB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Activin AB here. Most of them are supplied by our site. Hope this information will be useful for your research of Activin AB.
- Q&As
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Q&As (20)
Ask a questionDespite the distinct differences, there is still functional overlapping of responsiveness among the populations of activin AB-responding cells.
The characterization of activin-responding cells suggests the involvement of somatotropes (cells that produce growth hormone) and lactotropes (cells that produce prolactin) in activin-induced biological events in the pituitary.
Dysregulation of this pathway could potentially impact trophoblast function and contribute to pregnancy-related complications.
The modulation of activins AB could potentially have therapeutic applications for regulating hormone production and fertility in the reproductive system.
Activin AB produces comparable increases in human trophoblast cell invasion.
Activins AB down-regulate StAR expression, which is involved in the transport of cholesterol for progesterone production.
Activins AB stimulate aromatase/estradiol production in human granulosa-lutein cells.
Activin AB-responding cells were characterized based on their responsiveness in cytosolic free calcium ([Ca2+])i) to four hypothalamic releasing hormones: CRH, GHRH, TRH, and GnRH.
While somatotropes and lactotropes are implicated in activin-induced events, there may be other cell types in the pituitary that also respond to activin and play a role in these events.
Activin AB up-regulates N-cadherin expression in a SMAD2/3-SMAD4-dependent manner.
Activins are composed of homo- or heterodimers of inhibin β subunits and play important roles in the reproductive system.
Activins AB down-regulate StAR expression and decrease progesterone production in human granulosa cells.
It suggest that Activin AB may play a role in regulating trophoblast cell invasion, which is crucial for processes such as placental development and implantation.
The up-regulation of trophoblast cell invasion by Activin AB suggests that targeting this pathway could potentially be explored as a therapeutic strategy for trophoblast-related disorders, although further research is necessary to validate this possibility.
The regulatory effects of activins AB on granulosa cell steroidogenesis are likely mediated via an ALK4-mediated SMAD2/SMAD4-dependent pathway.
Activins AB induce aromatase/estradiol production but suppress StAR/progesterone production in human granulosa-lutein cells.
The information provided specifically mentions the involvement of the SMAD2/3-SMAD4 signaling pathway in mediating Activin AB's effects on trophoblast cell invasion. However, other signaling pathways may also contribute to this process and require further investigation.
Activin AB-responding cells are identified based on their specific responsiveness to activin AB, as observed through changes in cytosolic free calcium ([Ca2+])i) levels. This distinction helps differentiate them from other pituitary cell types.
The hypothalamic releasing hormones tested in relation to activin AB-responding cells are corticotropin-releasing hormone (CRH), growth hormone-releasing hormone (GHRH), thyrotropin-releasing hormone (TRH), and gonadotropin-releasing hormone (GnRH).
Yes, there are distinct differences among each population of activin AB-responding cells.
Customer Reviews (5)
Write a reviewWe have observed significant and reproducible functional outcomes, such as enhanced cell signaling or protein-protein interactions, when using this protein.
We received prompt assistance when troubleshooting experimental issues or interpreting experimental data related to the protein product.
The packaging of the protein product is designed to maintain its stability during transit, with appropriate temperature control measures in place.
We have conducted extensive quality control assays, including endotoxin testing and protein concentration determination, which consistently validate the high quality of the product.
We have repeatedly obtained consistent and reliable results using the protein product in different experimental conditions and cell types.
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