ADAMTS18
-
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 18
-
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. -
Synonyms
ADAMTS18; ADAM metallopeptidase with thrombospondin type 1 motif, 18; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 , ADAMTS21; A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAMTS 18; ADAMTS21; EC 3.4.24.; ADAM-TS18; ADAMTS-18; ADAM-TS 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21; KNO2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ADAMTS18-303H | Recombinant Human ADAMTS18 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ADAMTS18-26H | Recombinant Human ADAMTS18 protein, GST-tagged | E.coli | GST | ||
Human | ADAMTS18-302H | Recombinant Human ADAMTS18 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ADAMTS18-26HCL | Recombinant Human ADAMTS18 cell lysate | N/A | |||
Human | ADAMTS18-4728H | Recombinant Human ADAMTS18 protein, His-tagged | E.coli | His | 942-1047aa | |
Human | ADAMTS18-918HF | Recombinant Full Length Human ADAMTS18 Protein, GST-tagged | In Vitro Cell Free System | GST | 415 amino acids | |
Mouse | ADAMTS18-1315M | Recombinant Mouse ADAMTS18 Protein | Mammalian Cell | His | ||
Mouse | ADAMTS18-326M | Recombinant Mouse ADAMTS18 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ADAMTS18-326M-B | Recombinant Mouse ADAMTS18 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
ADAMTS18 involved in several pathways and played different roles in them. We selected most pathways ADAMTS18 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Degradation of the extracellular matrix | MMP17;TLL1;ADAMTS1;COL13A1;EMID2;COL15A1B;LOC100686744;MMP19;MMP11 |
Extracellular matrix organization | LEPRE1;MATN1;MFAP4;COL8A2;CTSD;CEACAM1;COL13A1;COL9A1B;COL3A1 |
Metabolism of proteins | SLC30A8;IGFBP5A;CTSG;MUC15;EEF1A2;CTDSP2;CNIH;MUC5AC;CBX8 |
O-glycosylation of TSR domain-containing proteins | ADAMTSL1;ADAMTS8;ADAMTSL5;ADAMTS18;ADAMTS10;ADAMTS4;ADAMTSL3;ADAMTS20;THSD1 |
O-linked glycosylation | ADAMTSL5;SPON2;MUC15;ADAMTSL4;ADAMTS8;GALNT5;MUC12;MUC1;MUC20 |
Post-translational protein modification | UBA2;SCMH1;NAPB;CNIH;SEC16B;MUC5AC;MAGT1;TRAPPC6BL;GCNT3 |
ADAMTS18 has several biochemical functions, for example, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS18 itself. We selected most functions ADAMTS18 had, and list some proteins which have the same functions with ADAMTS18. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
metalloendopeptidase activity | MMP28;PMPCB;C6AST4;PAPPAB;MME;Adamts19;ECEL1;ADAMTS13;ECE1 |
zinc ion binding | RP9;ZNF385D;DUSP12;DNLZ;LASP1;DNAJC21;ADAM8A;MMP7;GATA1A |
ADAMTS18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS18 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS18.
- Q&As
- Reviews
Q&As (8)
Ask a questionWe will provide customers with relevant technical support.
Yes, we will provide custom-manufactured recombinant proteins according to your requirements.
The structure of ADAMTS18 includes a signal peptide, a prodomain, a metalloproteinase domain, a disintegrin-like domain, a TSP1, a cysrich domain, a spacer and a TSP1-like repeat.
ADAMTS18 has been more frequently studied in esophageal cancer, osteosarcoma and endometrial cancer.
ADAMTS18 is mainly expressed in adult brain, prostate and retina tissues.
We have adopted multiple purification methods, including hydrophobic chromatography, affinity chromatography, ion exchange chromatography, salting out, molecular sieve, etc.
Expression of ADAMTS18 reduced cancer cell replication and growth, suggesting that it has a tumor-suppressive effect.
ADAMTS18 is mainly localized in the cytoplasm.
Customer Reviews (4)
Write a reviewThe delivery was fast, which solved my urgent needs.
The ADAMTS18 proteins purchased from your company is suitable for ELISA.
Purchased the right product at the right price and with the best quality.
The technicians understand the customer's experimental needs and have helped me to solve many of the problems that have arisen during the experiments.
Ask a Question for All ADAMTS18 Products
Required fields are marked with *
My Review for All ADAMTS18 Products
Required fields are marked with *