ADAP2
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Official Full Name
ArfGAP with dual PH domains 2
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Overview
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. -
Synonyms
ADAP2; ArfGAP with dual PH domains 2; CENTA2; cent-b; HSA272195; arf-GAP with dual PH domain-containing protein 2; cnt-a2; centaurin beta; centaurin-alpha-2; centaurin, alpha 2; centaurin-alpha 2 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ADAP2-0006H | Recombinant Human ADAP2 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ADAP2-336HCL | Recombinant Human ADAP2 cell lysate | N/A | |||
Human | ADAP2-243H | Recombinant Human ADAP2 Protein, His-tagged | E.coli | His | Cys49~Ser361 | |
Human | ADAP2-2578HF | Recombinant Full Length Human ADAP2 Protein, GST-tagged | In Vitro Cell Free System | GST | 380 amino acids | |
Mouse | Adap2-244M | Recombinant Mouse Adap2 Protein, His-tagged | E.coli | His | Ser49~Ser361 | |
Rat | ADAP2-509R | Recombinant Rat ADAP2 Protein | Mammalian Cell | His | ||
Rat | Adap2-245R | Recombinant Rat Adap2 Protein, His-tagged | E.coli | His | Ser49~Ser360 | |
Rat | ADAP2-165R | Recombinant Rat ADAP2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ADAP2-165R-B | Recombinant Rat ADAP2 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
ADAP2 involved in several pathways and played different roles in them. We selected most pathways ADAP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ADAP2 has several biochemical functions, for example, GTPase activator activity, inositol 1,3,4,5 tetrakisphosphate binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAP2 itself. We selected most functions ADAP2 had, and list some proteins which have the same functions with ADAP2. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | SRGAP2A;CDC42EP2;ARAP1;DEPDC1;RIC8;ARHGAP24;RAP1GAP;ERRFI1;TBC1D26 |
inositol 1,3,4,5 tetrakisphosphate binding | ITPR3;ADAP1;SYT2;ADAP2;AKR1C1 |
metal ion binding | ADAL;ZFP687;DYRK4;TRIM35-35;HBB-BH1;ZNF155;ZFP292;ZNF485;ZFPL1 |
phosphatidylinositol-3,4,5-trisphosphate binding | MAPKAP1;PHLDA3;OGT;DAPP1;NRGN;ARAP1;PARD3;KIF16B;RACGAP1 |
phosphatidylinositol-3,4-bisphosphate binding | MYO1G;KIF16B;ARAP3;COMMD1;MAPKAP1;ZFYVE1;GAB2;RAG2;TTPA |
phosphatidylinositol-4,5-bisphosphate binding | SESTD1;TTPA;AMER2;MARK1;RAG2;ADAP2;SYTL2;ALOX15;COMMD1 |
protein binding | CDC45;ASAP3;CBY1;P4HB;SIVA1;TEC;PPP1R16A;CNOT4;ARL6IP1 |
protein binding, bridging | NEFL;SPRR1B;GATAD2A;GOLGA5;IVL;FKBP4;NMD3;COL1A2;MEN1 |
ADAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAP2.
PRNP; IKBKG; EEF1G
- Q&As
- Reviews
Q&As (13)
Ask a questionCurrent research on ADAP2 protein is focused on understanding its role in various diseases, including cancer, hypertension, and neuropathic pain. Researchers are also investigating the molecular mechanisms underlying ADAP2 signaling pathways and identifying potential therapeutic targets for ADAP2-based therapies. Additionally, studies are ongoing to develop novel methods for detecting and measuring ADAP2 protein expression in clinical samples, which may have diagnostic and prognostic implications for various diseases.
One challenge associated with the development of ADAP2-based therapies is the limited knowledge of its molecular function and signaling pathway in different diseases. Additionally, the use of ADAP2-based therapies may also be limited by issues related to specificity, toxicity, and dosing. Thus, further research is needed to better understand the role of ADAP2 in various diseases and to identify safe and effective ways to target ADAP2 for therapeutic purposes.
There is currently no evidence to suggest that ADAP2 protein could be used as a diagnostic marker for any specific disease. However, research has shown that ADAP2 expression levels may be altered in certain diseases, such as cancer, suggesting that it may be a useful biomarker for disease progression or response to treatment. Further research is needed to determine the potential diagnostic role of ADAP2 in various diseases.
At present, there are no small molecule inhibitors or modulators of ADAP2 protein available. However, research is ongoing to identify and develop selective inhibitors or modulators of ADAP2 activity for therapeutic use in various diseases.
The potential applications of ADAP2 protein include drug discovery and development, diagnostics, and targeted therapies for various diseases, such as cancer, neuropathic pain, and inflammatory disorders. ADAP2 is involved in several cellular signaling pathways, including T-cell activation, cell adhesion, and migration, and has been shown to be overexpressed in certain cancers. This makes ADAP2 a potential drug target for cancer therapy. ADAP2 is also involved in the regulation of neuropathic pain, and targeting ADAP2 signaling may provide a novel strategy for treating this condition. Moreover, ADAP2 may serve as a biomarker for some diseases, and its detection in body fluids or tissues may aid in diagnosis and prognosis.
ADAP2 protein can be targeted for therapies aimed at specific diseases or conditions. For example, targeting ADAP2 with small molecule inhibitors or monoclonal antibodies may be effective in treating certain cancers or neuropathic pain. These therapies may work by selectively inhibiting ADAP2-mediated signaling pathways that contribute to disease development or progression. Development and optimization of ADAP2-targeted therapies can be facilitated by studies using ADAP2 protein in vitro and in vivo.
Currently, there are no clinical trials involving ADAP2 protein as a therapeutic target. However, there are preclinical studies investigating ADAP2-based therapies in various diseases, such as hypertension, neuropathic pain, and cancer.
ADAP2 protein can be used in drug discovery and development by serving as a target for small molecule inhibitors or monoclonal antibodies. These compounds can be designed to bind specifically to ADAP2 and block its function in various cellular signaling pathways. High-throughput screening methods can be used to identify lead compounds that show promising inhibition of ADAP2 activity. These compounds can then be optimized for potency, selectivity, and pharmacokinetic properties to develop potential drug candidates. Additionally, ADAP2 protein can be used in preclinical studies to evaluate the efficacy and safety of ADAP2-targeted therapies.
ADAP2 protein may be used in combination with other therapies to enhance their efficacy or overcome resistance. For example, ADAP2 inhibitors may be used in combination with blood pressure-lowering drugs to improve their effectiveness in the treatment of hypertension. Additionally, ADAP2 may also be involved in the development of drug resistance in cancer cells, and targeting ADAP2 in combination with chemotherapy or other targeted therapies may improve their efficacy.
ADAP2 protein can be used as a biomarker for the diagnosis of certain diseases. For example, ADAP2 expression has been shown to be elevated in some cancers, such as breast, lung, and ovarian cancers. Detection of ADAP2 in tumor tissues or blood samples may therefore aid in the diagnosis and prognosis of these cancers. In addition, ADAP2 may be a biomarker for other diseases, such as inflammatory disorders or neuropathic pain. Development of immunoassays or other detection methods specific for ADAP2 may enable its use as a diagnostic tool.
ADAP2 protein has potential applications in the treatment of various diseases, including cancer, neurological disorders, and cardiovascular diseases. For example, ADAP2 may play a role in the regulation of blood pressure and nerve function and may be targeted for the treatment of hypertension or neuropathic pain. Additionally, ADAP2 may also be involved in the development and progression of some cancers, and targeting ADAP2 may provide a novel therapeutic approach for cancer treatment.
Currently, there are no commercial sources of purified ADAP2 protein or antibodies available for purchase. However, researchers can obtain ADAP2 antibodies from custom antibody manufacturers and research supply companies. Researchers can also create their own ADAP2 antibodies using recombinant protein expression systems or through immunization of animals.
The exact mechanism of action of ADAP2 protein is not well understood. However, it has been suggested that ADAP2 may play a role in regulating protein-protein interactions and signal transduction pathways in various cell types. ADAP2 has been shown to interact with several other proteins, including tyrosine kinases, cytoskeletal proteins, and transcription factors, which may be involved in downstream signaling pathways related to cell growth, differentiation, and migration.
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