ADAR
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Official Full Name
adenosine deaminase, RNA-specific
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Overview
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. -
Synonyms
ADAR; adenosine deaminase, RNA-specific; G1P1, IFI4, interferon induced protein 4; double-stranded RNA-specific adenosine deaminase; ADAR1; dsRNA adenosine deaminase; interferon-induced protein 4; interferon-inducible protein 4; adenosine deaminase actin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human cells
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- DYKDDDDK
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ADAR Related Articles
ADAR involved in several pathways and played different roles in them. We selected most pathways ADAR participated on our site, such as C6 deamination of adenosine, Cytokine Signaling in Immune system, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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C6 deamination of adenosine | ADARB1;ADARB1A;ADAR |
Cytokine Signaling in Immune system | FRS2B;IFI35;IFITM3;IL1RN;JAK1;IFIT8;GBP6;UBE2V1;IFIT2 |
Cytosolic DNA-sensing pathway | POLR1D;IFN-a;OSTN;POLR3B;CASP1;Ifna11;POLR3GL;IFNA16;IFNA7 |
Formation of editosomes by ADAR proteins | ADARB1;ADAR;ADARB1A |
Gene Expression | PAPOLA;ZNF446;NR1I2;ZNF684;NR4A2A;CBX3;CHD4;PUS7;ZNF689 |
Immune System | TRIM31;RNF41;GBP6;AGER;IRF4;SIGLEC5;CYLD;IFI27;RNF138 |
Influenza A | IFNA5;IFNA13;TLR7;STAT1;AKT1;IRAK4;IRF3;PRKCB;PRSS2 |
Interferon Signaling | IFI35;IRF4;IFIT12;TRIM3;GBP6;TRIM68;TRIM8;TRIM17;TRIM14 |
ADAR has several biochemical functions, for example, DNA binding, double-stranded RNA adenosine deaminase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAR itself. We selected most functions ADAR had, and list some proteins which have the same functions with ADAR. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | TBX3A;ZNF763;MNX2A;ZMAT2;HOXB6A;ESR2B;RYBPB;FOXJ1A;ZNF507 |
double-stranded RNA adenosine deaminase activity | PKZ;ZBP1;ADARB1;ADAR |
metal ion binding | PNLIP;GNAQ;PPP4C;CYP46A1.2;CYP19A1B;RNF11A;LHX1B;SHRPRBCK1R;PLA2G4AA |
poly(A) RNA binding | TBL3;NOC2L;EEF2;SNRPA1;DHX8;KIAA0020;UTP3;DDX21;APOBEC3B |
protein binding | FMNL3;SCUBE3;TRPC4;HEY1;SRMS;TEAD4;CDX1;UFL1;HAND1 |
ADAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAR here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAR.
q99ib8-pro_0000045599; TGM2; cysK; q81xj3_bacan; pre-let-7a; AIM2; XRCC3; NS; ZFC3H1; MYC; NS; Junb; HNRNPA1; e3_vaccw; MATR3; Fus; Sesn2
- Q&As
- Reviews
Q&As (11)
Ask a questionADAR protein could be used in gene therapy to correct mutations or disease-causing sequences in RNA molecules by introducing specific nucleotide changes. This could potentially restore normal RNA and protein function and treat or cure genetic diseases.
ADAR protein can be used as a biomarker for the diagnosis or prognosis of certain diseases. Dysregulation of ADAR activity has been implicated in various cancers and viral infections, and detection of ADAR in blood or tissue samples may aid in the diagnosis and prognosis of these diseases. Furthermore, RNA editing patterns may differ between healthy and diseased tissues, suggesting that changes in the RNA editing profile may be used as a diagnostic tool.
ADAR protein can be targeted for therapies aimed at specific diseases or conditions. For example, targeting ADAR with small molecule inhibitors may be effective in treating certain cancers or viral infections. These therapies may work by selectively inhibiting ADAR-mediated RNA editing in cancer cells or the virus, leading to decreased tumor growth or viral replication. Additionally, ADAR may be targeted to modulate its activity in other diseases, such as autoimmune disorders. Development and optimization of ADAR-targeted therapies can be facilitated by studies using ADAR protein in vitro and in vivo.
It is not yet clear if there are any potential side effects of using ADAR protein for gene editing or therapy. One concern is off-target effects, where the protein may edit RNA at unintended sites, potentially leading to unintended consequences such as altering the function of proteins that are not targeted. Another concern is potential immune responses to the introduction of exogenous ADAR protein. However, much research is still needed to fully understand the safety of using ADAR-mediated gene editing or therapy.
One limitation of ADAR-mediated RNA editing is its efficiency, as it can be difficult to achieve high levels of editing in target RNA molecules. Additionally, RNA editing can have unpredictable consequences on protein structure and function, which could lead to unintended effects. Finally, the delivery of ADAR protein and guide RNAs to target cells or tissues can be challenging and may require further optimization.
ADAR protein has the advantage of being able to modify RNA sequences without altering the underlying DNA sequence. This makes it a potentially safer alternative to DNA-based gene editing tools such as CRISPR/Cas9, which can introduce unintended changes in the DNA sequence. Additionally, ADAR protein can target specific RNA sequences and modify them in a site-specific manner, which could reduce off-target effects.
ADAR protein has potential applications in gene editing and gene therapy, particularly for the treatment of genetic disorders such as cystic fibrosis, sickle cell anemia, and Huntington's disease. It may also have potential applications in cancer therapy, as well as in the study of RNA and its role in disease.
The potential applications of ADAR protein include gene editing, drug discovery and development, diagnostics, and targeted therapies for various diseases, including cancer and viral infections. ADAR protein is involved in RNA editing, a process that modifies RNA molecules after they are transcribed from DNA. RNA editing has been shown to be important in regulating gene expression, and abnormal RNA editing has been implicated in disease development. Thus, targeting ADAR protein or its function may provide opportunities for new therapeutic approaches.
ADAR protein can be used in drug discovery and development by serving as a target for small molecule inhibitors or by modulating its activity in disease states. ADAR activity has been shown to be dysregulated in various cancers and viruses, making ADAR a potential drug target for these diseases. Small molecule inhibitors of ADAR may be developed to selectively inhibit its activity and prevent abnormal RNA editing in cancer or viral infections. Additionally, ADAR protein may be used in preclinical studies to evaluate the efficacy and safety of ADAR-targeted therapies.
There is potential for ADAR protein to be used to treat neurological disorders. ADAR is involved in the regulation of RNA metabolism, which is critical for proper neuronal function. Dysregulation of RNA editing has been implicated in the pathogenesis of several neurological disorders, including Huntington's, Parkinson's, and Alzheimer's diseases. ADAR-mediated RNA editing may represent a potential therapeutic target for these disorders by correcting aberrant protein function or expression. Additionally, assessing ADAR expression and RNA editing may also provide a diagnostic or prognostic biomarker for these disorders.
ADAR protein can be used in gene editing by modifying RNA molecules. RNA editing changes the sequence of RNA by the insertion, deletion, or substitution of nucleotides. RNA editing can also modify splicing patterns, leading to the creation of new protein products. ADAR protein catalyzes the deamination of adenosine to inosine in RNA, and can be used to introduce specific changes in RNA sequences. RNA editing holds potential for correcting genetic defects or modifying gene expression in a variety of diseases, including cancer and genetic disorders.
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