ADARB1
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Official Full Name
adenosine deaminase, RNA-specific, B1
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Overview
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. -
Synonyms
ADARB1; adenosine deaminase, RNA-specific, B1; adenosine deaminase, RNA specific, B1 (homolog of rat RED1); double-stranded RNA-specific editase 1; ADAR2; ADAR2a; ADAR2a L1; ADAR2a L2; ADAR2a L3; ADAR2b; ADAR2c; ADAR2d; ADAR2g; DRABA2; DRADA2; hRED1; RED1; RED1 homolog (rat); ADARB 1; 1700057H01Rik; Adenosine deaminase, RNA specific, 2; Adenosine deaminase, RNA specific, B1 (RED1 homolog rat); Adenosine deaminase, RNA specific, B1; AW124433; AW558573; BB220382; D10Bwg0447e; Double stranded RNA specific editase 1; dsRNA adenosine deaminase; EC 3.5.-.-; Human dsRNA adenosine deaminase DRADA2; Human dsRNA adenosine deaminase DRADA2b, EC 3.5; OTTHUMP00000115341; OTTHUMP00000115342; RED 1; RNA editase; RNA editase 1; RNA editing deaminase 1; RNA editing enzyme 1; RNA editing enzyme 1, rat, homolog of; RNA specific adenosine deaminase B1; RED1 homolog; OTTHUMP00000115339; OTTHUMP00000115340; OTTHUMP00000174981; OTTHUMP00000214128; RNA-editing enzyme 1; RNA-editing deaminase 1; dsRNA ad;
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- Involved Pathway
- Protein Function
- Interacting Protein
- ADARB1 Related Articles
ADARB1 involved in several pathways and played different roles in them. We selected most pathways ADARB1 participated on our site, such as C6 deamination of adenosine, Formation of editosomes by ADAR proteins, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADARB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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C6 deamination of adenosine | ADARB1;ADARB1A;ADAR |
Formation of editosomes by ADAR proteins | ADAR;ADARB1A;ADARB1 |
Gene Expression | ZNF643;LCMT2;ZCRB1;ZNF606;ZNF485;CD3EAP;ZNF792;POLR3C;SUPT16H |
mRNA Editing | A1CF;ADARB1A;ADARB1;APOBEC1 |
mRNA Editing: A to I Conversion | ADARB1A;ADARB1 |
ADARB1 has several biochemical functions, for example, RNA binding, adenosine deaminase activity, double-stranded RNA adenosine deaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADARB1 itself. We selected most functions ADARB1 had, and list some proteins which have the same functions with ADARB1. You can find most of the proteins on our site.
Function | Related Protein |
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RNA binding | CNBPA;CSTF1;IFIT5;KHDC1A;PABPN1L;RPL30;IFIT14;AGO3B;RPL39L |
adenosine deaminase activity | ADARB2;ADAL;ADARB1;ADA;CECR1A;CECR1;ADAD2;ADARB1A;ADAD1 |
double-stranded RNA adenosine deaminase activity | ZBP1;ADAR;ADARB1;PKZ |
double-stranded RNA binding | DROSHA;ILF3;DICER1;OASL;LRRFIP1;DDX58;AGO3;ZNF346;OAS2 |
mRNA binding | G3BP1;RPS2;RPS13;IGF2BP1;CSTF2T;ITM2B;QKI;KHSRP;RBMX |
metal ion binding | CA;ZNF404;ITGA2B;NRXN1B;BCKDHA;RFESD;ESCO2;ZNF550;GFI1AA |
poly(A) RNA binding | DZIP3;HIST2H4;HMGB3;ZRANB2;HDAC2;SRSF11;MKRN1;HLTF;DDX31 |
protein binding | KSR1;TROAP;MZB1;UBE2IB;CD2;SMAD4;AGL;Pilrb1;MRPL15 |
ADARB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADARB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADARB1.
PIN1; WWP2; HNRNPA1; Rpl35; Ufl1
- Q&As
- Reviews
Q&As (12)
Ask a questionADARB1 is involved in the editing of pre-mRNA transcripts of several oncogenes and tumor suppressor genes that are known to play a role in cancer pathogenesis. By targeting ADARB1, it may be possible to alter the expression and function of these factors, leading to potential therapeutic benefits for cancer patients.
The use of ADARB1 in gene editing raises ethical concerns around the potential for unintended or unpredictable consequences. It raises questions about the safety, efficacy, and ethical implications of modifying genes and potential implications for future generations. Therefore, researchers should carefully consider the ethical implications of using ADARB1 gene editing techniques.
ADARB1 has been found to regulate tumor growth and metastasis in different types of cancer. Researchers are studying the role of ADARB1 in different cancer types and its potential as a therapeutic target. ADARB1 can be used to modify RNA molecules that are important for cancer progression.
The use of ADARB1 protein in gene editing and gene therapy is still in the experimental stages. While promising, additional research is needed to fully evaluate the safety and effectiveness of these approaches. Delivery of ADARB1 protein, as well as the accurate targeting of RNA editing sites, remains a challenge. Furthermore, off-target effects may still occur, potentially leading to unintended and harmful outcomes.
Currently, there are no FDA-approved drugs or therapies that specifically target ADARB1 protein. However, research is ongoing to develop small molecule inhibitors and other compounds that can modulate ADARB1 activity, with the aim of developing new treatments for neurological disorders and cancer.
The potential side effects of targeting ADARB1 protein are unknown at this time, as research in this area is still in its early stages. However, there is a risk that targeting ADARB1 could lead to unintended changes in gene expression or RNA editing, which could have negative consequences for cells or tissues. Careful monitoring and evaluation of potential side effects will be necessary as this area of research progresses.
ADARB1 protein is involved in both RNA editing and alternative splicing, which are two mechanisms for modifying gene expression. Specifically, ADARB1 catalyzes the deamination of adenosine (A) to inosine (I) in RNA, which can alter the sequence and structure of RNA transcripts. This can affect alternative splicing, which is the process by which different exons are included or excluded from a mature mRNA molecule. By regulating RNA editing and alternative splicing, ADARB1 plays an important role in controlling gene expression and protein function.
ADARB1 protein is important in the regulation of neurotransmitter receptors and ion channels, which play a vital role in the proper functioning of the nervous system. By targeting ADARB1, it may be possible to regulate the expression of genes involved in neurotransmitter signaling pathways, leading to potential therapeutic benefits for neurological disorders.
ADARB1 protein can be delivered to cells or tissues in different ways such as by viral vectors, nanoparticles, lipid-based delivery systems, or direct injection into the targeted area. Researchers are exploring ways to develop efficient and specific delivery systems for ADARB1 protein.
ADARB1 protein has potential applications in neurological disorders, such as epilepsy, depression, and multiple sclerosis. It is also being studied as a potential therapeutic target for the treatment of some cancers, including glioblastoma and colon cancer.
Yes, ADARB1 protein can be used in RNA editing for gene therapy applications. ADARB1 can target specific RNA sequences and modify them through deamination. By modifying RNA, ADARB1 can create or repair RNA molecules to treat genetic disorders caused by mutations in RNA sequences.
ADARB1 is being developed as a therapeutic target for various diseases and disorders, such as neurodegenerative diseases. Researchers are exploring ways to modify the activity of the ADARB1 protein through small molecules, RNA interference, and gene therapy. The goal is to increase or decrease ADARB1 activity as needed to treat or prevent the disease.
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