ADCY1A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ADCY1A-7643Z | Recombinant Zebrafish ADCY1A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ADCY1A involved in several pathways and played different roles in them. We selected most pathways ADCY1A participated on our site, such as Purine metabolism, Calcium signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Purine metabolism | IMPDH1;ENTPD6;ALLC;NUDT2;POLR1C;GC3;PRPS2;CECR1;POLR2K |
Calcium signaling pathway | HTR2C;DRD7;PDE1B;CALM2A;ADRB3A;SLC8A1B;PLCG1;SPHK1;PTGFR |
Oocyte meiosis | ANAPC7;PPP2CA;PPP2R5D;CALML3;SPDYB;CDK1;Ar;ITPR3;PPP1R2P9 |
Adrenergic signaling in cardiomyocytes | CACNG8;PPP2R2B;PLN;TMEM8C;FXYD2;GNAI1;ATP2B3B;CACNA1DA;CACNG6 |
Vascular smooth muscle contraction | PLCB3;PPP1CAA;ARHGEF1;CACNA1D;MYLK4;PLA2G2F;CACNA1SA;GNA11A;PRKACB |
Gap junction | RAF1B;PRKCBA;TUBB2;PRKCA;PRKACB;GRB2A;TUBA1L2;TUBA1L;HRAS |
GnRH signaling pathway | CALM1A;PLA2G4D;CALM1B;HRASB;LHB;EGFRA;MAPK14A;MAP2K1;PRKACBA |
Progesterone-mediated oocyte maturation | Adcy4;ANAPC13;CCNB2;FZR1;PRKACBA;CDC25A;CCNB1;CDK1;PIK3R3B |
Melanogenesis | PRKACBA;WNT5A;MAP2K2;NRAS;MAP2K2A;FZD9;ADCY2B;CREB3L2;FZD3B |
ADCY1A has several biochemical functions, for example, adenylate cyclase activity, lyase activity, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY1A itself. We selected most functions ADCY1A had, and list some proteins which have the same functions with ADCY1A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
adenylate cyclase activity | ADCY6;GNAS;ADCY9;ADCY7;Adcy4;ADCY8;ADCY1B;ADCY2B;ADCY1A |
lyase activity | FH1;GUCY2E;MOCOS;GUCY2F;GC2;PDXDC1;CAR5A;Car12;URAD |
nucleotide binding | PRKCHA;TIA1;GNAIA;CDC6;GNA15.1;GNA12A;ACTG2;FGFR1B;ATAD1B |
phosphorus-oxygen lyase activity | GC2;GUCY2E;BST1;ADCY1A;ADCY1B;ADCY2B;GC3;NPR1A;GUCY2F |
ADCY1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY1A.
- Q&As
- Reviews
Q&As (13)
Ask a questionADCY1A-targeted therapies are typically developed through a process that involves identifying potential compounds, testing their effects on ADCY1A activity and cAMP signaling in vitro and in animal models, and conducting clinical trials to evaluate their safety and efficacy in humans.
ADCY1A has been implicated in cancer progression and metastasis through its role in regulating cAMP signaling. Modulating ADCY1A activity may be a potential strategy for inhibiting cancer growth and metastasis, but more research is needed to evaluate the safety and efficacy of this approach.
The timeline for the development of ADCY1A-based therapies depends on various factors, including the complexity of the compounds and the regulatory requirements for conducting clinical trials. Some compounds may require years of preclinical studies before they can enter clinical trials, and the clinical trial process can take several years as well. It may be several years or even decades before ADCY1A-based therapies become available for clinical use.
ADCY1A can be targeted for medical applications through the development of compounds that modulate its activity or expression. These compounds can potentially increase or decrease cAMP signaling, depending on the specific application.
Challenges in the development of ADCY1A-based therapies include the lack of specificity of some compounds, potential toxicity issues, and the complexity of the cAMP signaling pathway. Moreover, the ethical concerns related to testing experimental drugs in humans, and the regulatory requirements for conducting clinical trials, can pose additional challenges.
Currently, there are no FDA-approved drugs that directly target ADCY1A. However, there are several drugs that indirectly affect cAMP signaling, including beta-blockers, which inhibit the activity of beta-adrenergic receptors that activate ADCY1A.
ADCY1A-based therapies could potentially improve the management of medical conditions by targeting key pathways involved in their pathogenesis. This could lead to better clinical outcomes, enhanced quality of life for affected individuals, and potentially reduce healthcare costs associated with these conditions.
ADCY1A has been implicated in various medical conditions, including cancer, metabolic disorders, and neurological disorders. Targeting ADCY1A may be a strategy to modulate cAMP signaling and improve the pathogenesis of these diseases.
Modulating ADCY1A activity offers a targeted approach to regulating cAMP signaling and downstream physiological processes, potentially minimizing off-target effects and toxicity associated with less specific approaches. Moreover, targeting ADCY1A can potentially activate or inhibit cAMP signaling in a cell- or tissue-specific manner, leading to more precise regulation of physiological processes.
The potential side effects of targeting ADCY1A depend on the specific compound and the extent of its effects on cAMP signaling. While some compounds may have minimal side effects, others may affect multiple physiological processes and have more significant side effects. More research is needed to fully evaluate the safety and efficacy of ADCY1A-targeted therapies.
There may be ongoing preclinical studies evaluating the effect of various compounds on ADCY1A activity and cAMP signaling. However, as of now, there are no known ADCY1A-based therapies in clinical trials for any disease or medical condition.
Different compounds are being developed to modulate ADCY1A activity, including small molecules, peptides, and antibodies. The effects of these compounds on cAMP signaling and downstream physiological processes are evaluated in cell culture studies, animal models, and clinical trials.
ADCY1A has been implicated in the pathogenesis of various diseases, including type 2 diabetes, heart failure, and cancer. Targeting ADCY1A may be a potential strategy for treating these conditions, as well as other diseases that involve dysregulation of cAMP signaling.
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