ADK
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Official Full Name
adenosine kinase
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Overview
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ADK; adenosine kinase; adenosine 5 phosphotransferase; AK; 5033405D03Rik; AI255373; AI987814; MGC6593; 2310026J05Rik; ADK_HUMAN; OTTHUMP00000019864; OTTHUMP00000019865; adenosine 5-phosphotransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bacillus subtilis
- Chicken
- E.coli
- Human
- Mouse
- Mycobacterium Tuberculosis
- Rat
- Rhesus Macaque
- S. flexneri
- Staphylococcus
- Streptomyces coelicolor A3(2)
- E. coli or Yeast
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- His|SUMO|Myc
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ADK Related Articles
- ADK Related Research Area
ADK involved in several pathways and played different roles in them. We selected most pathways ADK participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolic pathways | B3GNT5B;CYP3A25;RPIA;ATP6V1C1A;ATP5F1;GDA;IDO1;NAMPTB;ATP5A1 |
Metabolism | CYP4T8;AZIN1B;CYP3A7;Sult2a6;CSNK1G2;HIBADH;UGT1B2;PDK4;PDK2B |
Metabolism of nucleotides | DCK;GRX2;ADK;ADSSL1;PNP5B;GLRX;ADSL;PROZA;DPYDA.1 |
Purine metabolism | POLR3K;NME2B.1;PRIM2;NME1-NME2;CECR1;GC2;ADCY1A;AK5;POLR2I |
Purine salvage | PNP5B;ADA;ADK;ADAL;DGUOK;DCK;TM9SF1 |
adenine and adenosine salvage II | |
adenine and adenosine salvage VI | |
superpathway of purine nucleotide salvage |
ADK has several biochemical functions, for example, ATP binding, adenosine kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADK itself. We selected most functions ADK had, and list some proteins which have the same functions with ADK. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CKMT1;CAD;ADK;DAPK2;ATP2B2;BRAF;TBK1;DHX32A;HSPA12A |
adenosine kinase activity | ADK;ADKA;ADKB |
metal ion binding | GDPD2;SALL3;TRAF4A;KLF14;CYP46A1.2;ZFP64;PLD6;MGAT4A;BCMO1 |
poly(A) RNA binding | SNRPD3;EIF4E2;MECP2;HNRNPA1;ZMAT3;LUZP4;NHP2L1;ZC3H10;CANX |
ADK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADK here. Most of them are supplied by our site. Hope this information will be useful for your research of ADK.
btuB; FICD; SRD5A3; 15-deoxy-delta(12,14; bosutinib; imatinib; dasatinib; sch51344
- Q&As
- Reviews
Q&As (12)
Ask a questionAdenosine is a component of many foods, as it is a building block of nucleotides that are found in DNA and RNA. However, the amount of adenosine in these foods is typically negligible compared to the amount that is produced in the body. Some foods that contain adenosine include meats, fish, mushrooms, and yeast. However, it is important to note that dietary sources of adenosine are not typically used for their physiological effects, as adenosine usually acts within cells and tissues rather than circulating in the bloodstream.
Yes, adenosine can be used to diagnose heart conditions. Adenosine is a potent vasodilator, meaning that it can dilate blood vessels and increase blood flow to different parts of the body. During a cardiac stress test, a small amount of adenosine is injected into a vein in the arm to induce coronary vasodilation, which allows for better visualization of the heart and coronary arteries on imaging studies such as echocardiography or nuclear medicine scans. Adenosine is also used for certain types of heart rhythm tests, such as electrophysiology studies.
Adenosine has a potent effect on the heart and the cardiovascular system. It acts on specialized cells in the heart called pacemaker cells to slow down the heart rate and decrease the force of contraction. It also dilates the blood vessels, increasing blood flow and decreasing blood pressure. Adenosine is often used as a diagnostic tool for cardiac conditions, as it can reveal abnormalities in blood flow to the heart. Additionally, medications that affect adenosine receptors are used to treat conditions such as hypertension, angina, and arrhythmias.
Yes, caffeine can affect adenosine levels in the body. Caffeine blocks the activity of adenosine receptors in the brain, which leads to increased wakefulness and alertness. By blocking adenosine activity, caffeine can also indirectly increase levels of adenosine in the body. This can cause an increase in blood flow and oxygen delivery to the brain, which helps to counteract the tiredness and fatigue that can result from low levels of adenosine.
Researchers are exploring the use of ADK inhibitors as potential therapeutics for a range of medical conditions, including cancer, epilepsy, and inflammatory diseases. These inhibitors are being developed and tested in preclinical and clinical studies to determine their safety and efficacy. Additionally, researchers are studying the mechanisms by which ADK proteins and adenosine regulate various physiological processes, in order to develop more targeted and effective therapies.
ADK inhibitors have shown promising results in preclinical studies for the treatment of cancer. These inhibitors may help to decrease tumor growth and enhance the immune response against cancer cells. However, more research is needed before ADK inhibitors can be used clinically to treat cancer.
Drugs that modulate adenosine receptor activity can have a range of potential side effects, depending on the specific drug and the site of action. Some common side effects include headache, dizziness, nausea, and sleep disturbances. Drugs that activate adenosine receptors can also cause a decrease in heart rate and blood pressure, leading to symptoms such as faintness or lightheadedness. Conversely, drugs that block adenosine receptors can cause an increase in heart rate and blood pressure, as well as a decrease in blood flow to the brain.
Yes, the drug “Adenoscan” (adenosine injection) is a medication often used in medical imaging procedures that works by activating A2A adenosine receptors in the heart, which can help diagnose heart conditions.
Adenosine plays an important role in regulating the sleep-wake cycle. It accumulates in the brain during periods of wakefulness and activates adenosine receptors to promote sleepiness and prepare the brain for sleep. During sleep, adenosine levels decrease, allowing wakefulness-promoting chemicals to become more active. This cycle of adenosine accumulation during wakefulness and reduction during sleep helps to maintain a healthy sleep-wake cycle. Medications that affect the levels or activity of adenosine can also affect sleep and wakefulness.
Yes, research has shown that ADK inhibitors may have therapeutic potential in the treatment of various inflammatory conditions, such as rheumatoid arthritis, and neurological disorders, such as epilepsy.
As ADK-based therapies are still in the early stages of development, their safety profile has not yet been fully established. Some potential side effects may include liver toxicity or gastrointestinal discomfort. More research is needed to determine the safety and efficacy of ADK protein therapy.
Adenosine has anti-inflammatory effects due to its ability to modulate immune cell function and cytokine production. By inhibiting the activity of inflammatory cells and promoting the production of anti-inflammatory factors, adenosine can help to reduce inflammation in the body.
Customer Reviews (3)
Write a reviewI am confident that this protein will perform with reliability and consistency.
In addition to the high-quality product, the technical support provided by the manufacturer is outstanding.
The quality of the ADK protein is exceptional and it exceeds my experimental requirements.
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