ADO
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Official Full Name
2-aminoethanethiol (cysteamine) dioxygenase
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Overview
Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase;(ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to;form hypotaurine (Dominy et al., 2007 (PubMed 17581819)). -
Synonyms
ADO; 2-aminoethanethiol (cysteamine) dioxygenase; C10orf22, chromosome 10 open reading frame 22; 2-aminoethanethiol dioxygenase; cysteamine dioxygenase; FLJ14547; cysteamine (2-aminoethanethiol) dioxygenase (ADO); C10orf22; DKFZp564C046;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ADO Related Articles
ADO involved in several pathways and played different roles in them. We selected most pathways ADO participated on our site, such as Taurine and hypotaurine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Taurine and hypotaurine metabolism | GGT5A;GGT7;CSAD;GGT5;GAD2;GGT1A;GGT1;CDO1;GAD1 |
Metabolic pathways | PCYT2;CYP2B6;PRPS1L1;MGAT4C;GSTZ1;PSAT1;HMGCLL1;PON2;NSDHL |
ADO has several biochemical functions, for example, cysteamine dioxygenase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADO itself. We selected most functions ADO had, and list some proteins which have the same functions with ADO. You can find most of the proteins on our site.
Function | Related Protein |
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cysteamine dioxygenase activity | |
metal ion binding | E4F1;LATS2;ZFP652;HBAE1;ZNF865;OASL2;CD209B;DDHD1B;RNF180 |
ADO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADO here. Most of them are supplied by our site. Hope this information will be useful for your research of ADO.
FYCO1
- Q&As
- Reviews
Q&As (17)
Ask a questionYes, like any drug, ADO protein inhibitors can cause side effects. The most common side effects include nausea, vomiting, bone marrow suppression, and immunosuppression.
Yes, gene therapy is an approach that is currently being explored for the treatment of genetic disorders that involve ADO protein deficiencies, such as severe combined immunodeficiency (SCID). This approach involves delivering a functional copy of the ADO gene to cells that are deficient in the enzyme.
ADO proteins play a role in the regulation of immune responses that can influence tumor growth and development. In tumors, ADO proteins are often overexpressed, leading to increased immune suppression and allowing tumors to grow unchecked. Therefore, targeting ADO proteins is a promising approach for cancer therapy.
Although modulating ADO proteins has shown therapeutic potential in various diseases, there may be side effects associated with this approach. For example, inhibiting ADO proteins may lead to an increase in inflammation and immune activation, which can have negative effects on the body. Additionally, some drugs that target ADO proteins may have unwanted side effects, such as gastrointestinal disturbances and nausea.
Research has indicated that ADO proteins may play a role in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. These diseases involve the accumulation of abnormal protein aggregates in the brain, and research has suggested that ADO proteins may play a role in the clearance of these aggregates.
ADO inhibitors have been shown to have antiviral activity against a range of viruses, including HIV, hepatitis C, and Zika virus. They work by blocking the ability of viruses to replicate in host cells.
Yes, there are several drugs that target ADO proteins, including pentostatin, aminophylline, and caffeine. These drugs are used to treat various diseases, including leukemia and asthma, and work by inhibiting the activity of ADO proteins.
ADO proteins are a promising target for the development of new therapeutics for a range of diseases. Ongoing research is exploring new ADO inhibitors, as well as the potential use of ADO proteins as biomarkers for disease diagnosis and prognosis.
Yes, there are natural compounds that have been shown to modulate ADO proteins, such as green tea catechins and resveratrol. These compounds have been shown to have immunomodulatory effects and may be useful in the treatment of various diseases, including cancer and autoimmune diseases.
Yes, ADO proteins are a promising target for the development of new cancer therapies. ADO proteins are involved in immune regulation, and cancer cells can exploit this function to evade the immune system. Inhibiting ADO proteins may help to boost the immune response against cancer cells and improve the effectiveness of existing cancer therapies.
ADO proteins have been explored as potential biomarkers for disease diagnosis, including cancer and autoimmune diseases. However, their use as biomarkers is still in the experimental stages, and more research is needed to fully understand their utility in clinical diagnoses.
ADO proteins are involved in the catabolism of purine nucleotides, which are essential building blocks for DNA and RNA synthesis. By converting adenosine into inosine, ADO proteins help recycle purines and maintain normal purine metabolism in the body.
ADO proteins are involved in the regulation of immune responses and play a role in the development of autoimmune diseases. Inhibition of ADO proteins can enhance immune responses and improve the symptoms of autoimmune diseases.
es, ADO protein levels can be measured in the blood using various laboratory techniques, such as enzyme-linked immunosorbent assay (ELISA). These tests can be useful in diagnosing and monitoring certain diseases, such as leukemia.
Yes, several drugs that target ADO proteins are currently available, including pentostatin and cladribine. These drugs are used to treat hairy cell leukemia, a type of blood cancer.
ADO proteins interact with other enzymes in the body in various ways. For example, ADO proteins can interact with other enzymes in the purine metabolism pathway, such as purine nucleoside phosphorylase (PNP), to regulate the levels of purine nucleotides in the body. Additionally, ADO proteins can interact with enzymes involved in immune regulation, such as indoleamine 2,3-dioxygenase (IDO), to modulate immune responses.
Yes, ADO proteins are currently being investigated as a potential biomarker for various types of cancer, including leukemia, lymphoma, and solid tumors. ADO proteins are produced by cancerous cells and released into the bloodstream, where they can be detected and used to diagnose and monitor the progression of the disease.
Customer Reviews (5)
Write a reviewthe technical assistance team has been incredibly helpful in answering my questions and providing guidance on how to optimize my research.
This protein is of exceptional quality and perfectly suited for my experimental requirements.
I feel confident in my decision to use this protein and grateful for the excellent support from the manufacturer.
The analytical testing report confirms that it meets all the required specifications for my experiment.
The technical support offered by the manufacturer has been outstanding, ensuring that any issues or concerns I had were promptly resolved.
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