AICDA
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Official Full Name
activation-induced cytidine deaminase
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Overview
Activation-induced cytidine deaminase (AID) is thought to modify RNA due to its high homology to the RNA editing enzyme APOBEC-1. This function, however, has not been confirmed in in vitro studies, which show that AID has significant cytidine deaminase ac -
Synonyms
AICDA; activation-induced cytidine deaminase; cytidine aminohydrolase; activation induced deaminase; Aid; Arp2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
- His|Myc
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AICDA-7113H | Recombinant Human AICDA, His-tagged | E.coli | His | 1-198aa | |
Human | AICDA-1565H | Recombinant Human AICDA protein | E.coli | N/A | ||
Human | AICDA-471H | Recombinant Human AICDA Protein, GST-tagged | Wheat Germ | GST | ||
Human | AICDA-8958HCL | Recombinant Human AICDA 293 Cell Lysate | HEK293 | N/A | ||
Human | AICDA-953HF | Recombinant Full Length Human AICDA Protein, GST-tagged | In Vitro Cell Free System | GST | 198 amino acids | |
Human | AICDA-2783H | Recombinant Human AICDA Protein (1-198 aa), His-Myc-tagged | Insect Cell | His/Myc | 1-198 aa | |
Human | AICDA-2195H | Recombinant Human AICDA protein, His&Myc-tagged | Yeast | His&Myc | 1-198aa | |
Human | AICDA-0089H | Recombinant Human AICDA Protein (Gly23-Leu183), N-His-tagged | E.coli | N-His | Gly23-Leu183 | |
Mouse | Aicda-1566M | Recombinant Mouse Aicda protein | E.coli | N/A | ||
Mouse | AICDA-1447M | Recombinant Mouse AICDA Protein | Mammalian Cell | His | ||
Mouse | AICDA-409M | Recombinant Mouse AICDA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Aicda-2495M | Recombinant Mouse Aicda protein, His&Myc-tagged | E.coli | His&Myc | 1-198aa | |
Mouse | Aicda-1248M | Recombinant Mouse Aicda protein, His-tagged | Yeast | His | 1-198aa | |
Mouse | AICDA-409M-B | Recombinant Mouse AICDA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | AICDA-1868Z | Recombinant Zebrafish AICDA | Mammalian Cell | His | ||
Chicken | AICDA-4514C | Recombinant Chicken AICDA | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- AICDA Related Articles
- AICDA Related Research Area
AICDA involved in several pathways and played different roles in them. We selected most pathways AICDA participated on our site, such as Intestinal i, ne network for IgA production, Primary i, which may be useful for your reference. Also, other proteins which involved in the same pathway with AICDA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Intestinal i | IL15;TGFB1;AICDA;TNFSF13;TNFRSF13B;BLB1;CXCR4B;HLA-DOA;CD40 |
ne network for IgA production | HLA-DRB3;H2-AB1;LTBR;HLA-DOB;CCR10;HLA-DRB5;CXCR4B;CCR9A;HLA-DQA1 |
Primary i | CD3E;CD79A;CD4;IKBKG;BLNK;BTK;IGLL1;RFXAP;ZAP70 |
nodeficiency | RFXAP;CD8B;CD4;LCK;CD19;BTK;CD40;TNFRSF13B;RFX5 |
AICDA has several biochemical functions, for example, cytidine deaminase activity, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AICDA itself. We selected most functions AICDA had, and list some proteins which have the same functions with AICDA. You can find most of the proteins on our site.
Function | Related Protein |
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cytidine deaminase activity | CDA;APOBEC1;APOBEC3F;WBP2NL;APOBEC3G;APOBEC3H;APOBEC2;AICDA |
protein binding | PELI3;COMMD9;CCK;BMP1;LANCL2;UBR1;MOXD1;RNF213;ZNF335 |
ubiquitin protein ligase binding | MC4R;STX8;IKBKE;HSPA9;RIPK1;AICDA;NAE1;TRAF2;TNFRSF14 |
zinc ion binding | TRIM33;TNP2;ZFP276;PPARD;TRIM108;CA4B;LMO2;ZFAND2B;ADH1C |
AICDA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AICDA here. Most of them are supplied by our site. Hope this information will be useful for your research of AICDA.
TDG; DNAJA2; HSPA8; GADD45A; DNAJA1
- Q&As
- Reviews
Q&As (13)
Ask a questionAICDA introduces mutations into the variable regions of immunoglobulin genes that code for the antigen-binding site, leading to the production of various forms of antibodies. These diverse antibodies can recognize different epitopes of pathogenic antigens and improve the immune system's ability to neutralize them.
Current studies are aimed at further understanding AICDA’s involvement in various immune-related diseases, as well as the mechanisms regulating its activity, like the post-transcriptional regulation of AICDA by microRNAs. Additionally, researchers are investigating the potential therapeutic benefits of targeting AICDA in different disease conditions.
AICDA inhibition has been proposed as a potential therapy for autoimmune diseases and some autoimmune-like disorders, where reduction of autoantibodies can alleviate the symptoms. AICDA inhibition could also be a promising strategy in the treatment of certain types of B-cell lymphomas and leukemias, where oncogenic hypermutation of immunoglobulin genes is a crucial driver of tumor development.
AICDA mutations have been linked to several immunodeficiency diseases, such as hyper-IgM syndrome type 2, which is a rare genetic disorder characterized by a deficiency in immunoglobulin G, A, and E, and impaired production of antibodies. AICDA mutations have also been found in patients with common variable immunodeficiency, a group of disorders where patients have low levels of immunoglobulin and decreased ability to fight infections.
AICDA-mediated class-switching is a process by which B cells change the type of antibody they produce from IgM to other antibody isotypes, such as IgG, IgA, and IgE. This process expands the repertoire of antibodies and increases the diversity of effector functions that can be elicited during an immune response. Class-switching is crucial for the clearance of different types of pathogens and is also important for the maintenance of immune homeostasis.
AICDA-mediated somatic hypermutation can introduce mutations in oncogenes or tumor suppressor genes that promote uncontrolled cell proliferation and contribute to the development of lymphomas and leukemias. Moreover, AICDA activity has been shown to increase the risk of chromosomal translocations that lead to the formation of abnormal fusion proteins that promote malignant transformation.
No drugs that specifically target AICDA have been approved for clinical use yet. However, several AICDA inhibitors have been proposed and tested in preclinical studies, including small molecules that inhibit AICDA activity, or agents that interfere with AICDA-mediated DNA damage response.
Mutations in the AICDA gene have been linked to hyper-IgM immunodeficiency syndrome type 2, which is characterized by recurrent infections due to decreased levels of immunoglobulin. Moreover, AICDA mutations have also been linked to a higher incidence of B-cell lymphomas.
The expression of AICDA protein is regulated by various factors, including the activation of B cells by antigens, cytokines, and other immune cell signaling molecules. In addition, epigenetic factors, such as DNA methylation, histone modifications, and non-coding RNAs, can also regulate AICDA expression.
germinal center formation? Yes, AICDA is a crucial mediator of germinal center formation and function. Germinal centers are specialized sites within lymphoid organs where B cells undergo somatic hypermutation and class-switch recombination to produce high-affinity antibodies. AICDA is expressed by activated B cells within germinal centers and is responsible for the vast majority of somatic hypermutation.
AICDA-mediated somatic hypermutation is essential for the production of high-affinity antibodies against pathogens. However, it can also lead to the generation of autoantibodies that recognize and attack host tissues, contributing to the development of autoimmune diseases. AICDA is involved in the breakdown of self-tolerance and the activation of autoreactive B cells.
AICDA protein inhibitors have been developed for inhibiting the activity of AICDA protein. Some of the inhibitors include caffeine, quercetin, and theophylline.
Although AICDA is best known for its role in the immune system, recent studies have identified additional functions of AICDA in nonimmune cells. AICDA has been found to be involved in DNA demethylation, regulation of gene expression, and even lipid metabolism. AICDA expression has been observed in various nonimmune tissues, including the liver, brain, and adipose tissue, where it may have broader roles beyond its canonical function in antibody diversification.
Customer Reviews (5)
Write a reviewIts purity and functionality guarantee reliable and accurate results, ensuring the success of my research.
the superior quality of the AICDA protein, combined with the outstanding technical support from its manufacturer, instills confidence in its efficacy and suitability for my experimental needs.
the manufacturer of the AICDA protein provides exceptional technical support, making them an ideal partner in solving any challenges I may encounter during my experiments.
The AICDA protein is characterized by its impeccable quality, making it a perfect choice to fulfill my experimental requirements.
Their knowledgeable and responsive team is always ready to offer expert guidance, troubleshoot issues, and provide personalized solutions, ensuring a seamless research experience.
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