AIFM1
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Official Full Name
apoptosis-inducing factor, mitochondrion-associated, 1
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Overview
Apoptosis-inducing factor (Aif) is a ubiquitously expressed ~57 kDa mitochondrial flavoprotein (67-70 kDa primary transcript) that is capable of inducing chromatin condensation following an apoptotic stimulus. Synthesized in the cytoplasm, Aif is translocated to the intermembrane space of the mitochondria where it is normally found in non-apoptotic cells. Following an apoptotic signal, Aif is released to the cytoplasm from where it is translocated to the nucleus. Once in the nucleus, Aif is capable of inducing nuclear chromatin condensation and large scale DNA fragmentation. Redistribution of the Aif protein can be blocked by bcl-2. -
Synonyms
AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1; PDCD8, programmed cell death 8 (apoptosis inducing factor); apoptosis-inducing factor 1, mitochondrial; AIF; striatal apoptosis-inducing factor; programmed cell death 8 (apoptosis-inducing factor); PDCD8; COXPD6; MGC111425;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AIFM1 Related Research Area
AIFM1 involved in several pathways and played different roles in them. We selected most pathways AIFM1 participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIFM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis | TNF;CASP9;PRKACG;PRKACAA;PRKAR1AB;NMT1;TICAM1;CASP12;HMGB2A |
AIFM1 has several biochemical functions, for example, DNA binding, FAD binding, NAD(P)H oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AIFM1 itself. We selected most functions AIFM1 had, and list some proteins which have the same functions with AIFM1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF444;ZNF239;ZFP41;HIST1H3D;TBX5A;CRAMP1L;RIMKLB;RFX1A;ZFP319 |
FAD binding | DAO1;DAO.1;COQ6;CRY2;MTRR;DAO.3;MICAL1;DAO;AIFM1 |
NAD(P)H oxidase activity | DUOX2;AIFM1;KMO;NOX4;CYB5R4;DERL3 |
electron carrier activity | NDUFS6;ACOX3;AKR7A3;NDUFS2;DERL3;AOX4;ACOX2;GRXCR1;AIFM1 |
oxidoreductase activity, acting on NAD(P)H | WDR93;ECSIT;AIFM1;DECR1;DERL3;NDUFS8B;NDUFS8A;MIOX |
protein binding | PIK3CA;EIF3I;CSPG5;ABL1;ZNF593;BRD8;PHF21A;FOXP3;BBS12 |
protein dimerization activity | HER1;BTRC;MXD4;BHLHE41;TXLNB;MEF2AA;CELSR1;AHR1A;HPS1 |
AIFM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIFM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIFM1.
EIF3G; KANK2; HSPA1A; ILK; TSC22D4; PPIA
- Q&As
- Reviews
Q&As (14)
Ask a questionThe activity of AIFM1 protein is regulated by several mechanisms, including regulation of its translocation from the mitochondria to the nucleus, post-translational modifications, and interaction with other proteins. AIFM1 activity can be modulated by phosphorylation, acetylation, and ubiquitination, and these modifications can alter AIFM1's subcellular localization and interaction with binding partners.
AIFM1 protein is involved in cancer development through its regulation of cell death pathways. AIFM1 plays a dual role in cancer, depending on the cellular context. In some cases, AIFM1 promotes cancer cell survival by regulating mitochondrial energetics and metabolism, while in other cases, it facilitates apoptosis and cell death. AIFM1 has also been shown to promote apoptosis in cancer cells treated with chemotherapy drugs.
The expression of AIFM1 protein is influenced by various factors such as mitochondrial stress, reactive oxygen species (ROS), DNA damage, and hypoxia. Several transcription factors, including NF-κB and p53, have been reported to regulate AIFM1 expression.
Yes, AIFM1 protein is a potential therapeutic target for several diseases, including neurodegenerative disorders, cancer, and ischemia-reperfusion injury. Strategies such as small molecule inhibitors or gene therapy to regulate AIFM1 activity could be explored as potential therapeutic approaches. However, further research is needed to assess the safety and efficacy of such interventions.
AIFM1 protein contributes to ischemia-reperfusion injury by translocating from the mitochondria to the nucleus, where it induces DNA fragmentation and initiates apoptosis. This process can lead to tissue damage and cell death following reperfusion after an ischemic event. Inhibition of AIFM1 has been suggested as a potential therapeutic strategy to reduce ischemia-reperfusion injury.
Yes, changes in AIFM1 expression levels have been linked to several disease states. Loss of AIFM1 expression is associated with neurodegenerative disorders, while increased expression has been observed in some cancers. Dysregulation of AIFM1 activity has also been implicated in ischemia-reperfusion injury and metabolic disorders.
AIFM1 protein has been implicated in the pathogenesis of several neurodegenerative disorders, including Huntington's disease, Parkinson's disease, Alzheimer's disease, and Amyotrophic Lateral Sclerosis (ALS). AIFM1 is involved in the maintenance of mitochondrial function, and dysfunctional mitochondria play a significant role in the development of neurodegenerative disorders. Studies have revealed that AIFM1's translocation to the nucleus induces neuronal death in neurodegenerative diseases.
The techniques employed to study AIFM1 protein include Western blotting, immunofluorescence, RNAi knockdowns, co-immunoprecipitation, and in vitro protein-protein assays.
Several potential therapeutic strategies targeting AIFM1 are currently under investigation, including small molecules, siRNAs, and gene therapies, to treat various diseases, including neurodegenerative disorders, cancer, and ischemia-reperfusion injury.
AIFM1 protein plays a role in mitochondrial dynamics, which refers to the continuous processes of fission and fusion that maintain mitochondrial homeostasis. AIFM1 has been shown to interact with several proteins involved in mitochondrial fission, including Drp1 and Fis1, and its activity can promote fission or fusion of mitochondria depending on the cellular context. Dysregulation of mitochondrial dynamics has been implicated in several diseases, including neurodegenerative disorders.
AIFM1 has three isoforms: the full-length AIFM1, the truncated isoform AIFsh, and the mitochondrial-nuclear shuttle isoform AIF.
Several AIFM1 inhibitors/modulators, including Molecules, have been identified such as Dinaciclib, SMBA1, and Others.
Mutations in the AIFM1 gene have been associated with X-linked dominant traits such as optic atrophy, deafness, and neuropathy syndrome (ADOA+), Charcot-Marie-Tooth disease, a hereditary type of neuropathy, and Parkinsonism.
AIFM1 protein is involved in apoptosis, which is a programmed cell death process. AIFM1 translocates from the mitochondria to the nucleus during apoptosis, where it initiates DNA fragmentation and chromatin condensation, leading to cell death. AIFM1 activity is regulated by several factors, including the Bcl-2 family of proteins, which can promote or inhibit AIFM1-mediated apoptosis.
Customer Reviews (4)
Write a reviewIts reliability and the manufacturer's expertise will significantly bolster the impact and relevance of my research, particularly in unraveling the intricate mechanisms associated with AIF1 protein in various biological contexts.
The AIFM1 protein showcases exceptional quality that perfectly aligns with my experimental requirements.
Its purity, consistency, and stability make it an ideal choice to confidently drive my research forward and yield accurate and reliable results.
the manufacturer of the AIFM1 protein offers outstanding technical support, elevating their product to an even higher level of excellence.
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