AIFM2
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Official Full Name
apoptosis-inducing factor, mitochondrion-associated, 2
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Overview
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. -
Synonyms
AIFM2; apoptosis-inducing factor, mitochondrion-associated, 2; AMID, apoptosis inducing factor (AIF) like mitochondrion associated inducer of death; apoptosis-inducing factor 2; FLJ14497; PRG3; 5430437E11Rik; AIFM2_HUMAN; AMID; Apoptosis inducing factor (AIF) homologous mitochondrion associated inducer of death; Apoptosis inducing factor (AIF) like mitochondrion associated inducer of death; Apoptosis inducing factor mitochondrion associated 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death; Cys51Stop; HGNC11998; p53 responsive gene 3; p53 tumor suppressor; p53-responsive gene 3 protein; TRP53; Tumor protein p53; OTTHUMP00000019739; OTTHUMP00000019740; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of d; RP11-367H5.2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Human
- Mouse
- Taeniopygia guttata (Zebra finch) (Poephila guttata)
- Xenopus laevis (African clawed frog)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AIFM2-474H | Recombinant Human AIFM2 Protein, GST-tagged | Wheat Germ | GST | ||
Human | AMID-523H | Recombinant Human AMID protein, GST-tagged | Wheat Germ | GST | ||
Human | AIFM2-9504H | Recombinant Human AIFM2, GST-tagged | E.coli | GST | 1-373a.a. | |
Human | AIFM2-8953HCL | Recombinant Human AIFM2 293 Cell Lysate | HEK293 | N/A | ||
Human | AIFM2-016H | Recombinant Human AIFM2 Protein, His-tagged | E.coli | His | 2-373 | |
Human | AIFM2-1266H | Recombinant Human AIFM2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | AIFM2-956HF | Recombinant Full Length Human AIFM2 Protein, GST-tagged | In Vitro Cell Free System | GST | 373 amino acids | |
Mouse | AIFM2-1452M | Recombinant Mouse AIFM2 Protein | Mammalian Cell | His | ||
Mouse | Aifm2-1574M | Recombinant Mouse Aifm2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | AIFM2-412M | Recombinant Mouse AIFM2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Aifm2-1260M | Recombinant Mouse Aifm2 Protein, His-tagged | E.coli | N-His | Gly2-Pro373 | |
Mouse | AIFM2-412M-B | Recombinant Mouse AIFM2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bos taurus (Bovine) | RFL-10844BF | Recombinant Full Length Bovine Apoptosis-Inducing Factor 2(Aifm2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-373) | |
Taeniopygia guttata (Zebra finch) (Poephila guttata) | RFL-12462TF | Recombinant Full Length Taeniopygia Guttata Apoptosis-Inducing Factor 2(Aifm2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-373) | |
Xenopus laevis (African clawed frog) | RFL10621XF | Recombinant Full Length Xenopus Laevis Apoptosis-Inducing Factor 2(Aifm2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-374) | |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | RFL-31840XF | Recombinant Full Length Xenopus Tropicalis Apoptosis-Inducing Factor 2(Aifm2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-374) | |
Zebrafish | AIFM2-7901Z | Recombinant Zebrafish AIFM2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
AIFM2 involved in several pathways and played different roles in them. We selected most pathways AIFM2 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIFM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Direct p53 effectors | CD82;NDRG1;BCL2L14;AIFM2;DUSP5;CCNK;TADA2B;EDN2;TRIAP1 |
AIFM2 has several biochemical functions, for example, DNA binding, electron-transferring-flavoprotein dehydrogenase activity, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AIFM2 itself. We selected most functions AIFM2 had, and list some proteins which have the same functions with AIFM2. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | VED;CRSP7;LUC7L3;RPL6;NR1D2B;LEMD3;HIST1H111L;MYCN;PURBA |
electron-transferring-flavoprotein dehydrogenase activity | ETFDH;AIFM2 |
flavin adenine dinucleotide binding | AIFM3;MAOA;NOS3;D2HGDH;FMO5;ACADL;GCDH;FOXRED2;SDHA |
AIFM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIFM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIFM2.
MYC; USE1
- Q&As
- Reviews
Q&As (12)
Ask a questionAIFM2 inhibitors are compounds that inhibit the activity of AIFM2 protein. These inhibitors are being developed as potential therapeutics for diseases such as cancer and neurodegenerative disorders. In research, AIFM2 inhibitors are used to study the role of AIFM2 in cellular processes and to investigate the effects of inhibiting AIFM2 activity on disease outcomes.
Yes, changes in AIFM2 expression levels have been associated with several disease states. For example, decreased expression of AIFM2 has been linked with increased oxidative stress and mitochondrial dysfunction, which are both implicated in neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
Yes, AIFM2 protein has been shown to play a role in neuronal death and neurodegenerative diseases. AIFM2 is localized in the mitochondria and is involved in regulating mitochondrial function, which is critical for maintaining neuronal homeostasis. Dysregulation of AIFM2 has been observed in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, and has been associated with neuronal death.
AIFM2 expression is regulated at the transcriptional level by various transcription factors, including ATF4 and GABP. It can also be regulated at the post-transcriptional level by microRNAs, which can target the AIFM2 mRNA for degradation or inhibit its translation. In addition, AIFM2 expression can be influenced by cellular stress and disease states, which can impact its localization and activity.
The dysregulation of AIFM2 in neurodegenerative diseases implicates it as a potential therapeutic target. Targeting AIFM2 activity could potentially attenuate the neuronal death and degeneration observed in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. AIFM2 inhibitors are being developed as potential therapeutics for these conditions.
AIFM2 protein has been shown to play a role in cancer by regulating apoptosis and cell survival. Decreased expression of AIFM2 has been observed in several types of cancer, including breast, prostate, and colon cancer. This decreased expression is thought to contribute to the development and progression of cancer by inhibiting apoptosis and promoting cell survival.
The activity of AIFM2 protein is regulated by its subcellular localization, post-translational modifications, and interaction with other proteins. The protein contains a conserved N-terminal mitochondrial targeting sequence that directs it to the mitochondria. The activity of AIFM2 protein can be regulated by phosphorylation, acetylation, and S-nitrosylation, as well as by the binding of other proteins.
Yes, AIFM2 protein is a potential therapeutic target for several diseases, including neurodegenerative disorders and cancer. Strategies such as small molecule inhibitors or gene therapy to regulate AIFM2 activity could be explored as potential therapeutic approaches. However, further research is needed to assess the safety and efficacy of such interventions.
Yes, several genetic mutations have been identified in the AIFM2 gene that are associated with diseases. For example, a mutation in the AIFM2 gene has been linked to an autosomal recessive disorder characterized by deafness, optic neuropathy, and muscle weakness.
AIFM2 protein has been identified as a potential biomarker for several diseases, including neurodegenerative disorders and cancer. Changes in AIFM2 expression levels have been observed in these diseases, and measuring AIFM2 levels in biological samples such as blood or cerebrospinal fluid may provide a non-invasive way to monitor disease progression or response to treatment.
Yes, AIFM2 has emerged as a potential target for cancer therapy. Modulating AIFM2 expression or activity has been shown to impact cancer cell survival and proliferation, and AIFM2 inhibitors are being developed as potential therapeutics. Clinical trials are ongoing to evaluate the safety and efficacy of these inhibitors in cancer patients.
AIFM2 plays a role in regulating oxidative stress in cells. It is involved in maintaining mitochondrial function and regulating ROS levels. Dysregulation of AIFM2 has been associated with increased cellular oxidative stress, which can contribute to the pathogenesis of various diseases such as cancer and neurodegenerative disorders.
Customer Reviews (3)
Write a reviewTheir prompt and reliable assistance enables me to navigate through protocols, troubleshoot issues, and interpret complex data, ensuring the successful completion of my research goals.
the exceptional quality of the AIFM2 protein, combined with the manufacturer's exceptional technical support, positions it as an invaluable asset for my experimental endeavors.
With their extensive knowledge and expertise, they are well-equipped to address any challenges or inquiries that may arise during my experiments.
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