AJUBA
-
Official Full Name
ajuba LIM protein
-
Overview
Ajuba is a member of LIM domain containing proteins that contribute to cell fate determination and regulate cell proliferation and differentiation. Ajuba is also involved in the regulation of actin cytoskeleton dynamics and cell migration. Ajuba plays a important role in the regulation of the kinase activity of AURKA/Aurora A for mitotic commitment. Is also a component of the IL 1 signaling pathway modulating IL 1 induced NF kappa B activation by influencing the assembly and activity of the PRKCZ/SQSTM1/TRAF6 multiprotein signaling complex. Ajuba is also a negative regulator of the Wnt signaling pathway. -
Synonyms
AJUBA; ajuba LIM protein; JUB; LIM domain-containing protein ajuba; jub, ajuba homolog;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | AJUBA-5096HCL | Recombinant Human JUB 293 Cell Lysate | HEK293 | N/A | ||
Human | AJUBA-5097HCL | Recombinant Human JUB 293 Cell Lysate | HEK293 | N/A | ||
Mouse | Ajuba-1252M | Recombinant Mouse Ajuba Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Rat | AJUBA-581R | Recombinant Rat AJUBA Protein | Mammalian Cell | His | ||
Rat | AJUBA-237R | Recombinant Rat AJUBA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | AJUBA-237R-B | Recombinant Rat AJUBA Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- AJUBA Related Research Area
- AJUBA Related Signal Pathway
AJUBA involved in several pathways and played different roles in them. We selected most pathways AJUBA participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AJUBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Hippo signaling pathway | LLGL1;SMAD2;PPP2CA;SMAD1;MPP5;FZD9;FZD6;APC2;WNT10B |
AJUBA has several biochemical functions, for example, actin filament binding, alpha-catenin binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AJUBA itself. We selected most functions AJUBA had, and list some proteins which have the same functions with AJUBA. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
actin filament binding | SCIN;ERMN;CTNNAL1;TRIOBP;PLS1;PPP1R9A;MYO1E;EGFR;MYH9 |
alpha-catenin binding | JUB;PKP2;NUMB;AJUBA;JUPA;CDH24;CTNNB1;CDH2;JUP |
chromatin binding | TCF7;ATF5;ATF2;SFPQ;TAL1;RING1;HMGB3;ELK4;PBX2 |
protein binding | MUSK;CLIC2;CKB;MAPKAPK5;TBX15;BOC;ATP6V0C;CBLN3;USP17L2 |
transcription corepressor activity | LMCD1;LOXL2;TBL1Y;TBL1XR1;SAP30;HIF3A;NR1H4;GMNN;SKOR1A |
zinc ion binding | RNF168;ZNF638;MUL1;RNF150;RNF141;RLIM;NR5A1A;ADA;MLLT6 |
AJUBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AJUBA here. Most of them are supplied by our site. Hope this information will be useful for your research of AJUBA.
LATS2; SNAI1; SFN; GFI1B; cadh1_human_gene
- Q&As
- Reviews
Q&As (12)
Ask a questionYes, AJUBA protein plays a role in cell adhesion and migration. It interacts with proteins involved in cell-cell adhesion, such as alpha-catenin, and can influence the stability and formation of adherens junctions. AJUBA's interactions with actin cytoskeletal regulators, such as LIMK1 and cofilin, suggest its involvement in cell migration and cytoskeletal dynamics.
Abnormalities in AJUBA protein have been implicated in certain human diseases and conditions. For example, AJUBA has been found to be dysregulated in various types of cancers, including breast, lung, and colorectal cancer.
In addition to its roles in cell proliferation, migration, and adhesion, AJUBA protein also regulates embryonic development, tissue regeneration, and organ size control. It is involved in controlling the balance between cell proliferation and differentiation during development. In certain tissues, AJUBA protein is crucial for tissue homeostasis and regeneration after injury.
Mutations or genetic variations in the AJUBA gene have been associated with certain diseases. Notably, AJUBA mutations have been linked to the development of hepatocellular carcinoma, a type of liver cancer. Additionally, AJUBA variants have been implicated in the susceptibility to obesity and metabolic syndrome. However, more research is needed to fully understand the impact of AJUBA genetic variations on disease pathogenesis.
AJUBA protein is predominantly found in the nucleus of the cell. However, it can also localize to other cellular compartments, such as the cytoplasm and cell-cell junctions, depending on the context and cellular conditions.
AJUBA protein interacts with numerous binding partners, contributing to its functional diversity. Some of its known binding partners include LATS kinases, which regulate cell proliferation and apoptosis, YAP/TAZ transcriptional coactivators, Wnt signaling proteins, and components of adherens junctions, such as alpha-catenin.
The potential diagnostic and prognostic utility of AJUBA protein is still being investigated. Studies have suggested its involvement in cancer progression and prognosis, particularly in hepatocellular carcinoma. However, more research is necessary to validate AJUBA as a reliable biomarker and to determine its clinical significance in various diseases.
Yes, mouse models and knockout studies have been conducted to investigate the function and importance of AJUBA protein. AJUBA knockout mice display various developmental defects, including embryonic lethality, abnormal development of tissues such as the heart, lung, and skin, and impairment of epithelial cell differentiation. These studies highlight the essential role of AJUBA in embryonic development and tissue homeostasis.
AJUBA protein is regulated by multiple mechanisms, including post-translational modifications, protein-protein interactions, and subcellular localization. Phosphorylation events can modulate the activity and localization of AJUBA, affecting its interactions with other proteins. Additionally, AJUBA can be regulated by upstream signaling pathways, such as the Hippo pathway, which can impact its stability and function.
Given its involvement in cancer and other diseases, AJUBA protein may be a potential target for therapeutic interventions. However, specific strategies targeting AJUBA are still under investigation. Further understanding of AJUBA's functional roles and its downstream signaling pathways may offer opportunities for developing therapeutic approaches that could modulate its activity in disease contexts.
Yes, AJUBA protein can interact with other PDZ domain-containing proteins. For example, it has been shown to associate with DLG1 (Discs Large Homolog 1) and ZO-2 (Zonula Occcludens-2), both of which are involved in cell adhesion and junction formation. These interactions allow AJUBA to participate in the assembly and stabilization of cell-cell junctions.
AJUBA protein can modulate cell proliferation and tumorigenesis through its interactions with various signaling pathways. For instance, it has been shown to regulate the activity of YAP/TAZ transcriptional coactivators, a key pathway involved in cell growth and organ size control. AJUBA can also interact with components of the Hippo signaling pathway, which influences cell proliferation and organ development.
Customer Reviews (4)
Write a reviewthe manufacturer of the AJUBA protein sets an exemplary standard by offering exceptional technical support, poised to address any obstacles that may arise during my experimental journey.
AJUBA protein emerges as an epitome of superior quality, tailor-made to fulfill my experimental requirements with utmost precision.
Their team of seasoned professionals possesses profound expertise in all aspects pertaining to the AJUBA protein
The manufacturer's commitment to delivering exceptional support guarantees that I can navigate through my research endeavors smoothly and with utmost confidence.
Ask a Question for All AJUBA Products
Required fields are marked with *
My Review for All AJUBA Products
Required fields are marked with *