ALDH3A2
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Official Full Name
aldehyde dehydrogenase 3 family, member A2
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Overview
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ALDH3A2; aldehyde dehydrogenase 3 family, member A2; ALDH10, SLS; fatty aldehyde dehydrogenase; FALDH; aldehyde dehydrogenase 10; microsomal aldehyde dehydrogenase; aldehyde dehydrogenase family 3 member A2; SLS; ALDH10; FLJ20851; DKFZp686E23276;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ALDH3A2 involved in several pathways and played different roles in them. We selected most pathways ALDH3A2 participated on our site, such as Glycolysis / Gluconeogenesis, Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH3A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycolysis / Gluconeogenesis | PDHA1;PFKP;GPI;LDHC;PDHA1B;PKM;GPIB;ACSS1;GPI1 |
Pentose and glucuronate interconversions | UGT1A1;UGT1AB;SORD;ALDH2.1;ALDH2;ALDH3A2A;UGT5G1;UGT2B15;UGT1A2 |
Ascorbate and aldarate metabolism | UGT1A1;UGT1A6A;GULO;ALDH3A2A;UGT2B7;UGT2B15;UGT2A3;UGT1A7;ALDH2.2 |
Fatty acid degradation | ADH1A;HADHAB;ACSL1A;ACSL3;GCDHB;ADH6;CPT1B;ALDH3A2A;ALDH9A1A.1 |
Valine, leucine and isoleucine degradation | ACAA2;MCCC1;OXCT2B;BCAT2;ALDH6A1;HIBADH;ALDH2.1;ACAT2;OXCT1 |
Lysine degradation | KMT2A;ALDH2;MLL1;PLOD2;HADHAA;ALDH7A1;WBP7;SETDB2;C2orf34 |
Arginine and proline metabolism | DHDPSL;SMS;DAO.2;OAT;AGMAT;CKBB;SAT2;GOT1;PRODH |
Histidine metabolism | AMDHD1;ALDH1B1;MAOB;ALDH3B1;ALDH1A3;ABP1;ALDH2.1;UROC1;ALDH3A2A |
Tryptophan metabolism | MAOA;CCBL1;ACAT2;MAOB;HADHAB;TDO2;ALDH2.2;GCDHA;DHCR24 |
beta-Alanine metabolism | AOC2;ALDH2.1;HADHAB;ALDH1A3;MLYCD;ALDH6A1;ALDH2.2;ALDH2;SMS |
Glycerolipid metabolism | LIPG;ALDH2;MBOAT1;PPAP2B;PPAP2D;AGPAT1;DAK;DGKD;AKR1B10 |
Pyruvate metabolism | GLO1;ACSS2L;ME1;BRP44;ACOT12;MDH2;HAGH;PKMA;FH1 |
Metabolic pathways | AGPAT9L;ATP6V0D2;CERS5;OTC;CHPF;GCLC;ITPK1A;GPIA;BPGM |
ALDH3A2 has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH3A2 itself. We selected most functions ALDH3A2 had, and list some proteins which have the same functions with ALDH3A2. You can find most of the proteins on our site.
Function | Related Protein |
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3-chloroallyl aldehyde dehydrogenase activity | ALDH9A1;ALDH3A1;ALDH3A2;ALDH1A1;ALDH3B1;ALDH2.1;ALDH3A2B;ALDH3A2A;Aldh1a7 |
aldehyde dehydrogenase (NAD) activity | ALDH3A2;ALDH3B2;ALDH1L2;ALDH1A1;ALDH16A1;ALDH9A1A.1;ALDH1A3;ALDH6A1;ALDH8A1 |
aldehyde dehydrogenase [NAD(P)+] activity | ALDH3B2;ALDH3A2A;ALDH3A2;ALDH3A1;ALDH3B1;ALDH3A2B;ALDH2;ALDH1A3 |
long-chain-alcohol oxidase activity | |
long-chain-aldehyde dehydrogenase activity | |
medium-chain-aldehyde dehydrogenase activity |
ALDH3A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH3A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH3A2.
Stag2; USP50; Mad2l2; p29991-pro_0000037946; midostaurin; AIM2; PPP6R2; GABARAP; 1C; MME; CAPZA2; GABARAPL2; Tubg1; Smn1; KPNB1; Prkci; Atp7a; ATL3; Tnpo1
- Q&As
- Reviews
Q&As (13)
Ask a questionCurrently, there are no specific drugs or treatments designed to target ALDH3A2 directly. However, certain therapeutic strategies are being explored to alleviate the symptoms of Sjögren-Larsson syndrome (SLS), which is caused by mutations in the ALDH3A2 gene. These include symptomatic management of ichthyosis with moisturizers and emollients to improve the skin condition, physical therapy for spasticity management, and potentially gene therapy approaches to correct the underlying genetic defect in affected individuals. The development of targeted treatments for ALDH3A2-related conditions is an area of active research.
Yes, ALDH3A2 is expressed in various tissues besides the skin, albeit at lower levels. It is found in the liver, brain, adipose tissue, and other organs. It is believed that ALDH3A2's enzyme activity in these tissues is involved in the metabolism of fatty aldehydes and in protecting cells against oxidative damage.
Gene therapy holds promise as a potential treatment for Sjögren-Larsson syndrome (SLS), which is caused by mutations in the ALDH3A2 gene. Preclinical studies using animal models have shown positive results, with gene replacement strategies effectively restoring ALDH3A2 activity and improving symptoms. However, the development of safe and effective gene therapy approaches for SLS is still in the early stages, and more research is needed before it can be considered a viable treatment option for SLS.
ALDH3A2 has not been widely established as a biomarker for specific diseases or conditions. However, ALDH enzymes, including ALDH3A2, have been implicated in certain cancers, such as breast cancer and hepatocellular carcinoma, where their dysregulation may contribute to tumor progression and drug resistance. Further studies are needed to evaluate the potential use of ALDH3A2 as a biomarker for these diseases or other conditions.
Besides its role in lipid metabolism and detoxification, ALDH3A2 has been implicated in other biological processes. Some studies have suggested a potential involvement of ALDH3A2 in cell proliferation, differentiation, and apoptosis. However, the exact mechanisms and significance of these observations are still under investigation. Further research is needed to fully understand the broader biological functions of ALDH3A2.
The regulation of ALDH3A2 protein expression and activity is not yet fully understood. However, studies have indicated that certain transcription factors, such as PPARα (peroxisome proliferator-activated receptor alpha) and AP-1 (activator protein 1), can influence ALDH3A2 gene expression. Additionally, oxidative stress and inflammatory signals have been shown to affect ALDH3A2 activity. Further research is needed to fully elucidate the regulatory mechanisms of ALDH3A2.
ALDH3A2 has been found to interact with various proteins to form functional complexes. For instance, it has been shown to interact with several aldehyde dehydrogenases, such as ALDH1A1 and ALDH1A3. These interactions suggest potential cooperative roles in aldehyde metabolism. ALDH3A2 has also been observed to interact with proteins involved in lipid metabolism, oxidative stress response, and cellular detoxification pathways. Further research is needed to fully understand the interactome of ALDH3A2 and its significance in cellular processes.
The identification of specific natural inhibitors or activators of ALDH3A2 is still an area of ongoing research. However, certain compounds and substances have been found to modulate the activity or expression of ALDH enzymes in general, including ALDH3A2. For example, disulfiram, a drug mainly used in the treatment of alcoholism, has been shown to inhibit various ALDH isoforms, including ALDH3A1 and ALDH1A1. Additionally, certain dietary factors and environmental chemicals may influence ALDH activity. Further studies are needed to determine any specific natural compounds that directly modulate ALDH3A2 activity.
Currently, there is no cure for Sjögren-Larsson syndrome, and treatment focuses on managing the symptoms. Skin care to alleviate ichthyosis, physical and occupational therapies to address spasticity and motor difficulties, and educational support for intellectual disability are among the treatment approaches. Additionally, medications such as retinoids may be prescribed to improve skin symptoms in some cases. However, ongoing research aims to develop targeted therapies that can address the underlying cause of the disease by restoring ALDH3A2 function or reducing the accumulation of fatty aldehydes.
ALDH3A2 is primarily known as an enzyme. It belongs to the aldehyde dehydrogenase enzyme family, which catalyzes the oxidation of aldehydes to their corresponding acids. ALDH enzymes are widely involved in various metabolic pathways. However, like many enzymes, ALDH3A2 does have certain structural characteristics that are important for its function, including specific amino acid residues that contribute to its active site and enzymatic activity.
ALDH3A2 is essential for the normal metabolism of lipids, specifically fatty aldehydes. It catalyzes the conversion of fatty aldehydes into fatty acids, which are essential components of triglycerides, phospholipids, and other lipid molecules. Dysfunction of ALDH3A2 leads to the accumulation of fatty aldehydes, disrupting lipid metabolism and contributing to the pathogenesis of Sjögren-Larsson syndrome.
While mutations in the ALDH3A2 gene are primarily associated with Sjögren-Larsson syndrome, there have been rare reports of individuals with ALDH3A2 mutations exhibiting symptoms that do not fit the classic SLS triad. These atypical presentations include cases with intellectual disability and spasticity but without ichthyosis. However, the exact implications of these variants and their association with other conditions are still being investigated.
Mutations in the ALDH3A2 gene are associated with a rare autosomal recessive disorder called Sjögren-Larsson syndrome (SLS). SLS is characterized by a triad of symptoms including ichthyosis (a scaly skin condition), intellectual disability, and spasticity (stiff, rigid muscles). These mutations result in a deficiency of ALDH3A2 enzyme activity and the subsequent accumulation of fatty aldehydes, leading to the development of SLS.
Customer Reviews (4)
Write a reviewThe bands of proteins in Western Blotting experiments were very clear.
Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.
Its versatility allows me to explore its diverse roles in various biochemical and biological processes accurately.
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