ALDH3A2A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ALDH3A2A-11926Z | Recombinant Zebrafish ALDH3A2A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ALDH3A2A involved in several pathways and played different roles in them. We selected most pathways ALDH3A2A participated on our site, such as Glycolysis / Gluconeogenesis, Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH3A2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Glycolysis / Gluconeogenesis | AKR1A1;G6PC;ALDH1B1;PGAM1B;PKMA;TPI1A;ALDOAB;FBP1A;PDHA2 |
Pentose and glucuronate interconversions | AKR1B1L;CRYL1;XYLB;UGT1A6;DHDH;ALDH2;OXSR1;UGP2;UGT1A7 |
Ascorbate and aldarate metabolism | UGT2A1;UGT1A6;UGT1A2;UGT2A3;UGDH;ALDH3A2;ALDH2.2;UGT1A6A;GULO |
Fatty acid degradation | ALDH2;ACSL4;CYP4A10;ACSL4B;ALDH7A1;ALDH3A2;ACSL4A;ACSL1;CPT1A |
Valine, leucine and isoleucine degradation | HIBCH;ALDH9A1A.1;ALDH2.1;HADHB;HMGCS2;OXCT2B;ALDH3A2;OXCT2A;ACADSB |
Lysine degradation | ALDH2.2;EHHADH;EHMT1;ALDH3A2A;SETD8;HADHA;ALDH3A2;SUV39H1A;ALDH7A1 |
Arginine and proline metabolism | ALDH2;GOT2;PRODH2;ALDH3A2A;CNDP2;ALDH1B1;DAO.2;SAT1;AZIN2 |
Histidine metabolism | ALDH9A1;UROC1;MAOA;ALDH1B1;ALDH3A1;ALDH9A1B;AOC1;ALDH3B1;CARNS1 |
Tryptophan metabolism | KMO;AADAT;AANAT;DHCR24;ALDH3A2A;MAOA;ALDH9A1;AOC1;TPH1A |
beta-Alanine metabolism | CNDP1;SMOX;HADHAB;ALDH6A1;ALDH3A1;HIBCH;ACADM;HADHA;ALDH9A1B |
Glycerolipid metabolism | ALDH9A1;PNPLA3;LPIN1;ALDH2.2;AGK;ALDH1B1;ALDH3A2;AGPAT3;ALDH9A1B |
Pyruvate metabolism | PC;PDP1;MPC1;PDK2B;ACAT1;PDHA2;SLC16A8;ALDH2.1;ME3 |
Metabolic pathways | NDUFC2;GUK1B;PLCB4;ADKA;NME6;GALNT5;CRYL1;GCNT4;POLD4 |
ALDH3A2A has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH3A2A itself. We selected most functions ALDH3A2A had, and list some proteins which have the same functions with ALDH3A2A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
3-chloroallyl aldehyde dehydrogenase activity | ALDH3B2;ALDH1A1;ALDH9A1;ALDH3A2A;ALDH3A2;ALDH2.1;ALDH3B1;ALDH3A2B;Aldh1a7 |
aldehyde dehydrogenase (NAD) activity | ALDH1A1;ALDH3A2A;ALDH9A1;ALDH1A3;ALDH8A1;Aldh1a7;ALDH9A1B;ALDH16A1;ALDH3A1 |
aldehyde dehydrogenase [NAD(P)+] activity | ALDH3A1;ALDH3A2A;ALDH3B1;ALDH1A3;ALDH3A2;ALDH3A2B;ALDH2;ALDH3B2 |
oxidoreductase activity | YWHAQB;CYP2K18;YWHABL;CYP2AA6;CYP2AA8;CYP2K22;CYP2X9;ALOX5B.3;DHRS12 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | ALDH9A1A.2;ALDH3A2B;ALDH2.2;ADH4;ALDH9A1B;ALDH2.1;ALDH3A2A;Aldh1a7;ALDH9A1A.1 |
ALDH3A2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH3A2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH3A2A.
- Q&As
- Reviews
Q&As (11)
Ask a questionThe specific inhibitors or activators of ALDH3A2 have not been extensively characterized. However, it is known that ALDH3A2 activity can be influenced by its substrate availability and cellular environment. For example, increased levels of long-chain fatty aldehydes, the substrates of ALDH3A2, may stimulate its activity. On the other hand, conditions that decrease substrate availability or impair the function of ALDH3A2 may inhibit its activity. Further research is needed to identify pharmacological inhibitors or activators that can modulate ALDH3A2 function.
As of my knowledge cutoff date, I do not have access to real-time information about ongoing clinical trials. To find the most up-to-date and accurate information about clinical trials targeting ALDH3A2, it is recommended to search clinical trial databases like ClinicalTrials.gov or consult with medical professionals or researchers specializing in the field.
The interactions and associations of ALDH3A2 with other proteins or molecules are not extensively studied. However, ALDH3A2 has been reported to associate with protein kinase C delta (PKCδ) and protein kinase C zeta (PKCζ) in keratinocytes, suggesting a potential involvement of these proteins in ALDH3A2 regulation or function.
Mutations in the ALDH3A2 gene lead to the development of Sjögren-Larsson syndrome (SLS), which is characterized by a triad of symptoms: ichthyosis (dry, scaly skin), intellectual disability, and spastic diplegia or tetraplegia (spasticity in the limbs). These mutations disrupt the function of the ALDH3A2 protein, impairing its ability to efficiently metabolize long-chain fatty aldehydes. The accumulation of these aldehydes in the body results in the characteristic symptoms associated with SLS.
While the primary function of ALDH3A2 is the oxidation of lipophilic aldehydes, it may also have additional roles in cellular processes. For example, ALDH3A2 has been implicated in the protection of cells against oxidative stress by reducing the levels of lipid peroxidation products. It may also play a role in the metabolism of retinoids, as suggested by its association with the retinoic acid signaling pathway. However, further research is needed to fully understand the involvement of ALDH3A2 in these processes and pathways.
The regulation of ALDH3A2 expression and activity is not fully understood. However, certain transcription factors and signaling pathways have been implicated in its regulation.
Yes, ALDH3A2 exhibits tissue-specific expression patterns. It is highly expressed in tissues rich in lipid metabolism, such as the skin, liver, and adipose tissue. Within the skin, ALDH3A2 is primarily expressed in the sebaceous glands. The tissue-specific expression of ALDH3A2 suggests its important role in lipid metabolism and protection against toxic aldehydes in these tissues.
Yes, mutations in the ALDH3A2 gene are associated with Sjögren-Larsson syndrome (SLS), a rare autosomal recessive disorder. SLS is characterized by a triad of symptoms: ichthyosis (dry, scaly skin), intellectual disability, and spastic diplegia or tetraplegia (spasticity in the limbs). These symptoms result from the accumulation of long-chain fatty aldehydes due to impaired ALDH3A2 function. SLS is a chronic disorder that affects multiple systems, including the skin, central nervous system, and musculoskeletal system.
As Sjögren-Larsson syndrome (SLS) is caused by mutations in the ALDH3A2 gene, therapeutic strategies targeting ALDH3A2 could potentially be beneficial for treating this disorder. Currently, there are no specific treatments for SLS, and management focuses on alleviating the symptoms. However, gene therapy approaches, such as gene replacement or gene editing techniques, may hold promise for correcting the underlying genetic defect in ALDH3A2.
ALDH3A2 is expressed in various tissues and organs throughout the body. It is primarily found in the skin where it participates in lipid metabolism and detoxification of aldehydes produced during cellular processes. ALDH3A2 expression has also been detected in other tissues such as the liver, brain, kidney, lung, and eye, indicating its involvement in general aldehyde detoxification and lipid metabolism in these organs as well.
The specific interacting partners of ALDH3A2 have not been extensively characterized. As of now, there are no well-established protein-protein interactions reported for ALDH3A2 in public protein interaction databases. Further research is needed to identify and characterize potential interacting proteins that may be involved in modulating the activity of ALDH3A2 or its involvement in various cellular processes.
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Write a reviewThe ALDH3A2A Protein is of exceptional quality and is precisely tailored to meet my experimental requirements.
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The ALDH3A2A Protein exhibits remarkable stability and functionality, making it an optimal choice for a wide range of applications in various fields.
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