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ALDH9A1

Official Full Name

aldehyde dehydrogenase 9 family, member A1
Overview

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.
Synonyms

ALDH9A1; aldehyde dehydrogenase 9 family, member A1; ALDH4, ALDH7, ALDH9; 4-trimethylaminobutyraldehyde dehydrogenase; E3; 4 trimethylaminobutyraldehyde dehydrogenase; AL9A1_HUMAN; aldehyde dehydrogenase (NAD+); Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1; ALDH4; ALDH7; ALDH9; Gamma aminobutyraldehyde dehydrogenase; Gamma-aminobutyraldehyde dehydrogenase; R aminobutyraldehyde dehydrogenase; R-aminobutyraldehyde dehydrogenase; TMABADH; OTTHUMP00000032604;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ALDH9A1-454H	Recombinant Human ALDH9A1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ALDH9A1-61HCL	Recombinant Human ALDH9A1 cell lysate		N/A		Inquiry
Human	ALDH9A1-6469H	Recombinant Human ALDH9A1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ALDH9A1-1418HF	Recombinant Full Length Human ALDH9A1 Protein, GST-tagged	In Vitro Cell Free System	GST	494 amino acids	Inquiry
Human	ALDH9A1-3945H	Recombinant Human ALDH9A1 protein, His-tagged	E.coli	His	285-412 aa	$319 / 25ug
Mouse	Aldh9a1-1360M	Recombinant Mouse Aldh9a1 protein, His & T7-tagged	E.coli	His/T7	Leu322~Phe494 (Accession # Q9JLJ2)	Inquiry
Mouse	Aldh9a1-1595M	Recombinant Mouse Aldh9a1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	ALDH9A1-624R	Recombinant Rat ALDH9A1 Protein	Mammalian Cell	His		Inquiry
Rat	ALDH9A1-280R	Recombinant Rat ALDH9A1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ALDH9A1-280R-B	Recombinant Rat ALDH9A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
ALDH9A1 Related Articles

ALDH9A1 involved in several pathways and played different roles in them. We selected most pathways ALDH9A1 participated on our site, such as Glycolysis / Gluconeogenesis, Ascorbate and aldarate metabolism, Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycolysis / Gluconeogenesis	G6PCA.1;G6PC3;BPGM;AKR1A1B;G6PCA.2;PDHA1B;PFKMA;LDHC;LDHBA
Ascorbate and aldarate metabolism	UGT2B15;UGT1A7C;ALDH1B1;UGT1A9;GULO;ALDH9A1A.1;UGT5G1;UGT2B7;UGT1A1
Fatty acid degradation	ACSL1;ACADS;ACSL1A;ALDH9A1;ACSL4;ACADVL;ALDH7A1;ACSBG1;ADH7
Valine, leucine and isoleucine degradation	HSD17B10;ACADSB;MUT;ACAA1;DLDH;BCKDHA;OXCT1B;OXCT1;ALDH9A1A.1
Lysine degradation	AGPHD1;EHHADH;SETD8B;HYKK.2;SETD8A;OGDHA;SUV420H1;SETD1B;ALDH2
Arginine and proline metabolism	CARNS1;DAO1;SRM;SAT2;PYCRL;P4HA1;ALDH4A1;ARG2;CKMT1A
Histidine metabolism	AMDHD1;ALDH3A2;ALDH1A3;MAOB;ALDH3A2A;ALDH2;ALDH3B1;ABP1;ALDH9A1
Tryptophan metabolism	CCBL1;HADHAB;GCDHA;ALDH1B1;ALDH9A1B;OGDHL;ALDH2.2;AOX3L1;AOC1
beta-Alanine metabolism	HADHA;CARNS1;ALDH2;ALDH1B1;ALDH9A1A.1;ALDH3A1;UPB1;ALDH3A2;GAD1
Glycerolipid metabolism	LIPCA;PPAP2B;MBOAT2B;LPIN2;DGKG;DGKZ;LIPF;LIPG;GPAT2
Pyruvate metabolism	PDK3;PKLR;SLC16A8;ACSS2L;PKM2;FH;LDHBB;ALDH2;DLAT
Metabolic pathways	ISYNA1;GCH2;ALPI;PAFAH1B2;MTMR2;COQ7;SAT2;GCSHB;COQ2

ALDH9A1 has several biochemical functions, for example, 1-pyrroline dehydrogenase activity, 3-chloroallyl aldehyde dehydrogenase activity, 4-trimethylammoniobutyraldehyde dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH9A1 itself. We selected most functions ALDH9A1 had, and list some proteins which have the same functions with ALDH9A1. You can find most of the proteins on our site.

Function	Related Protein
1-pyrroline dehydrogenase activity
3-chloroallyl aldehyde dehydrogenase activity	ALDH3B2;ALDH3B1;ALDH3A1;Aldh1a7;ALDH3A2A;ALDH9A1;ALDH1A1;ALDH3A2B;ALDH3A2
4-trimethylammoniobutyraldehyde dehydrogenase activity	ALDH9A1A.1;ALDH9A1B;ALDH9A1
aldehyde dehydrogenase (NAD) activity	ALDH1L1;ALDH3B2;Aldh1a7;ALDH3A1;ALDH3A2A;ALDH1A3;ALDH1L2;ALDH16A1;ALDH9A1A.1
aminobutyraldehyde dehydrogenase activity	ALDH9A1A.1;ALDH9A1B;ALDH9A1

ALDH9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH9A1.

HLA-B; USP46; TNIP3; DDA1; flgH1; GABARAPL1

Yang, Y; Zhou, W; et al. NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma. ONCOTARGET 5:11986-11997(2014).

Li, XS; Xu, Q; et al. ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer. BMC CANCER 14:-(2014).