ALOX5A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Zebrafish | ALOX5A-8198Z | Recombinant Zebrafish ALOX5A | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
ALOX5A involved in several pathways and played different roles in them. We selected most pathways ALOX5A participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | PTGESL;FAAH2;PTGES3A;ALOX5B.2;GPX5;PLA2G4A;CYP2C45;PTGDSB;LTC4S |
| Metabolic pathways | HPDB;MINPP1B;LASS5;NDUFS8B;BCAT1;SYNJ1;ACSL5;MSMO1;CHPF2 |
ALOX5A has several biochemical functions, for example, arachidonic acid monooxygenase activity, dioxygenase activity, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX5A itself. We selected most functions ALOX5A had, and list some proteins which have the same functions with ALOX5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arachidonic acid monooxygenase activity | ALOX5A;CYP4A10;CYP4A14;CYP4F14 |
| dioxygenase activity | ALOX5B.3;LEPREL1;ALOX12E;PTGS1;OGFOD2;PTGS2;ALOX5B.2;ALOX5A;ALOX8 |
| iron ion binding | CYP46A1.3;CYP2C18;CYP26A1;EGLN1B;MFI2;ACO2;CYP4Z1;CYP3A7;C14orf169 |
| metal ion binding | NUDT4;THOP1;MKNK2;KITA;PM20D1;ZFP770;UGP2;ZXDB;PPTC7 |
| oxidoreductase activity | IYD;CYP2C54;BCO2L;AIFM4;ALDH3A2B;CYP4A10;CYP2K17;RDH13;DCT |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | P4HA2;ALOX5B.3;TMLHE;ALOX5B.2;P4HA1;ALOX12;ALOX5A;P4HA1B;BCO2 |
ALOX5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX5A here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX5A.
- Q&As
- Reviews
Q&As (12)
Ask a questionALOX5A has been linked to diseases such as asthma, allergies, atherosclerosis and liver fibrosis.
ALOX5A belongs to the large family of proteins lipoxygenases with a similar tertiary structure, consisting of two distinct parts of the C-terminal catalytic domain and the N-terminal containing a transmembrane helical domain containing different numbers of mitochondria.
A high-sugar, high-fat diet can induce the expression and activity of ALOX5A and increase leukotriene synthesis.
ALOX5A is mainly expressed in white blood cells, such as neutrophils and monocytes.
ALOX5A is an enzyme whose primary function is to catalyze the conversion of arachidonic acid into leukotrienes in various lipids.
Leukotriene has physiological functions such as inflammation, immune response regulation and cell proliferation.
ALOX5A is related to diet, environment, genes and other factors.
ALOX5A is widely used in drug development, such as in the treatment of asthma, dermatitis, liver fibrosis, liver ® and other diseases.
Current relevant data show that the deletion of ALOX5A gene is related to obesity, diabetes, cardiovascular disease and other diseases.
The metabolite leukotriene catalyzed by ALOX5A can affect the production of factors and physiological activities such as inflammation and immune response by regulating the expression of genes such as Cyclooxygenase-2 (COX-2) and Interleukin-8 (IL-8).
ALOX5A is used as a potential target in drug development and can be targeted by different compounds or molecules to regulate its function or product production.
Leukotriene, a metabolite catalyzed by ALOX5A, can regulate physiological processes such as inflammation and immune response by activating NF-κB signaling pathway and Akt signaling pathway.
Customer Reviews (4)
Write a reviewALOX5A is well suited for use in our laboratory because they can be stored for a long time and maintain their original properties.
The sensitivity of ALOX5A in Western blot was very high and low concentrations of the target protein could be detected.
ALOX5A has a wide range of products to meet our needs in different research areas.
Using ALOX5A as a catalyst, the rate and yield of chemical reactions can be significantly increased with high catalytic efficiency.
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