ALT
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Kit-2209 | Alanine Aminotransferase Activity Colorimetric/Fluorometric Assay Kit | N/A | ||||
ALT-116 | Recombinant ALT protein, His-tagged | E.coli | His | |||
Kit-0082 | Alanine Transaminase Assay Kit | N/A | ||||
Kit-0083 | ALT Assay Kit | N/A | ||||
Kit-0084 | ALT Fluorometric Assay Kit | N/A |
- ALT Related Articles
ALT involved in several pathways and played different roles in them. We selected most pathways ALT participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ALT has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ALT itself. We selected most functions ALT had, and list some proteins which have the same functions with ALT. You can find most of the proteins on our site.
Function | Related Protein |
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ALT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALT here. Most of them are supplied by our site. Hope this information will be useful for your research of ALT.
- Q&As
- Reviews
Q&As (10)
Ask a questionALT expression is regulated by transcription factors, epigenetic modifications, and signaling pathways, such as Wnt/尾-catenin, MYC, or TGF-尾 signaling, providing insights into its regulation under different cellular conditions.
ALT interacts with various proteins, including transcription factors, chromatin remodelers, and co-regulators, influencing gene expression, DNA repair, or chromatin organization.
ALT plays essential roles in telomere maintenance, cellular senescence, telomere recombination, and alternative lengthening of telomeres (ALT) pathway activation.
ALT undergoes post-translational modifications, including phosphorylation, acetylation, and SUMOylation, which can modulate its activity, stability, and recruitment to telomeres or subcellular compartments.
ALT exhibits enzymatic activity as a DNA-dependent RNA polymerase, catalyzing the synthesis of RNA from a DNA template, but its specific substrates and metabolic pathways are still being elucidated.
Genetic alterations in ALT-related genes or mutations affecting telomere maintenance components are linked to telomere dysfunction disorders or predisposition to cancer development.
Therapeutic strategies targeting ALT or its associated pathways may hold potential for cancer therapy by exploiting ALT activation as a vulnerability or developing specific inhibitors to disrupt ALT activity and telomere maintenance in cancer cells.
Dysregulation of ALT has been implicated in various diseases, including cancer, where ALT activation is associated with telomere maintenance and genomic instability.
Structural studies have revealed key domains in ALT, such as the reverse transcriptase domain, telomerase essential N-terminal (TEN) domain, and RNA-binding motifs, providing insights into its function and catalytic mechanism.
ALT is primarily localized in the nucleus, but it can also be found in the cytoplasm and other cellular compartments, depending on the cell type and context.
Customer Reviews (3)
Write a reviewConvenient and efficient protein labeling options.
Reduced nonspecific binding for cleaner data interpretation.
Excellent resolution in protein separation techniques.
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