ALYREF
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Official Full Name
Aly/REF export factor
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Synonyms
ALYREF;Aly/REF export factor;19071;ENSG00000183684;ALY;BEF;REF;THOC4;ALY/REF;17q25.3;THO complex subunit 4;THO complex subunit 4;tho4;THO complex 4;bZIP enhancing factor;ally of AML-1 and LEF-1;bZIP-enhancing factor BEF;transcriptional coactivator Aly/REF;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- N
- MBP
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ALYREF-9606H | Recombinant Human ALYREF Protein(11-250aa), His-tagged | E.coli | C-His | 11-250aa | |
Human | ALYREF-512H | Recombinant Human ALYREF protein, GST-tagged | Wheat Germ | GST | ||
Human | ALYREF-9607H | Recombinant Human ALYREF Protein(11-250aa), MBP&His-tagged | E.coli | N-MBP & C-His | 11-250aa | |
Human | ALYREF-1114HF | Recombinant Full Length Human ALYREF Protein, GST-tagged | In Vitro Cell Free System | GST | 257 amino acids | |
Mouse | ALYREF-1584M | Recombinant Mouse ALYREF Protein | Mammalian Cell | His | ||
Mouse | ALYREF-496M | Recombinant Mouse ALYREF Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ALYREF-496M-B | Recombinant Mouse ALYREF Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | ALYREF-5987Z | Recombinant Zebrafish ALYREF | Mammalian Cell | His | ||
Chicken | ALYREF-5241C | Recombinant Chicken ALYREF | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ALYREF involved in several pathways and played different roles in them. We selected most pathways ALYREF participated on our site, such as RNA transport, mRNA surveillance pathway, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALYREF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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RNA transport | PRMT5;FXR2;EIF2B4;SUMO1;EIF3HA;SIP1;POP5;GEMIN6;SUMO3 |
mRNA surveillance pathway | PPP2R5EA;NXF2;PPP2CB;pab1;MSI2B;GSPT2;PABPC1B;WIBG;PPP2R2A |
Spliceosome | CDC5L;SNRPD3;RBM8A;PRPF6;PPIL1;NHP2L1;PRPF40A;PPIH;ISY1-RAB43 |
Herpes simplex infection | SRSF6B;BMA1;JAK2B;PER2;FAS;SRSF4;POU2F3;GLTSCR2;IFNA16 |
ALYREF has several biochemical functions, for example, RNA binding, nucleic acid binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALYREF itself. We selected most functions ALYREF had, and list some proteins which have the same functions with ALYREF. You can find most of the proteins on our site.
Function | Related Protein |
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RNA binding | SPI1;TIMM50;AGO3B;RBFOX1L;HNRPKL;PPARGC1A;CRNKL1;EIF3B;PSMA1 |
nucleic acid binding | SCRT1A;ZFML;JRKL;EIF2C3;ZFP354B;Akap17b;TRNAU1APA;ZBTB42;FAM200A |
nucleotide binding | ABCC12;TINAG;DNM2B;MXG;UMPS;RBM4.2;UBE2L3A;RNPC3;IGF1RA |
single-stranded DNA binding | WBP11;SSBP4;MEIOB;SSBP3B;NABP2;LONP1;MCM4;HMGB2;PCBP1 |
ALYREF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALYREF here. Most of them are supplied by our site. Hope this information will be useful for your research of ALYREF.
THRAP3; Ywhae; Trpm7
- Q&As
- Reviews
Q&As (10)
Ask a questionALYREF interacts with other mRNA export factors, such as NXF1, NXT1, and UAP56, as well as RNA binding proteins, transcription factors, and RNA helicases to coordinate mRNA export processes.
ALYREF contributes to the regulation of gene expression by influencing the export efficiency of specific mRNA subsets, thereby impacting their translation and protein production.
Targeting ALYREF pharmacologically may offer a means to modulate mRNA export and gene expression, potentially influencing disease-related processes, including cancer progression or viral replication.
ALYREF expression, localization, or activity can be regulated by signaling pathways, such as the PI3K/AKT/mTOR pathway or stress response pathways, to modulate mRNA export under specific conditions.
ALYREF undergoes phosphorylation, acetylation, and methylation, which can regulate its RNA binding affinity, nuclear-cytoplasmic shuttling, or interactions with other proteins.
ALYREF depletion or overexpression can lead to defects in mRNA export, altered gene expression patterns, and impaired cellular processes, such as compromised proliferation, impaired differentiation, or increased sensitivity to stress.
ALYREF dysfunction has been implicated in various diseases, including cancer, neurological disorders, and viral infections. Its altered expression or subcellular localization may serve as diagnostic or prognostic markers in certain disease contexts.
ALYREF plays a crucial role in mRNA export by interacting with mRNA export factors, nuclear pore components, and RNA molecules to facilitate their transport across the nuclear envelope.
ALYREF participates in mRNA surveillance mechanisms, including the recognition and removal of aberrant or misprocessed mRNAs, preventing their export to the cytoplasm.
ALYREF contains RNA recognition motifs (RRMs) that bind to specific RNA sequences or structures, such as exon junction complexes (EJCs) or specific mRNA export elements.
Customer Reviews (3)
Write a reviewEnhanced signal amplification for improved sensitivity.
Precise determination of protein half-life.
Compatibility with various downstream applications (e.g., mass spectrometry).
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