ANAPC15
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Official Full Name
anaphase promoting complex subunit 15
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Synonyms
ANAPC15;anaphase promoting complex subunit 15;24531;ENSG00000110200;APC15;HSPC020;C11orf51;11q13.4;DKFZp564M082;anaphase-promoting complex subunit 15;anaphase-promoting complex subunit 15;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ANAPC15 -471H | Recombinant Human ANAPC15 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ANAPC15-8346HCL | Recombinant Human C11orf51 293 Cell Lysate | HEK293 | N/A | ||
Human | ANAPC15-1824HF | Recombinant Full Length Human ANAPC15 Protein, GST-tagged | In Vitro Cell Free System | GST | 121 amino acids | |
Human | ANAPC15-366H | Recombinant Human ANAPC15 Protein (1-121 aa), GST-tagged | E.coli | GST | 1-121 aa | |
Rat | ANAPC15-664R | Recombinant Rat ANAPC15 Protein | Mammalian Cell | His | ||
Rat | ANAPC15-320R-B | Recombinant Rat ANAPC15 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | ANAPC15-320R | Recombinant Rhesus monkey ANAPC15 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ANAPC15-148R-B | Recombinant Rhesus Macaque ANAPC15 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | ANAPC15-148R | Recombinant Rhesus Macaque ANAPC15 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | ANAPC15-4395Z | Recombinant Zebrafish ANAPC15 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ANAPC15 Related Articles
ANAPC15 involved in several pathways and played different roles in them. We selected most pathways ANAPC15 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ANAPC15 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC15 itself. We selected most functions ANAPC15 had, and list some proteins which have the same functions with ANAPC15. You can find most of the proteins on our site.
Function | Related Protein |
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ANAPC15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC15.
b4ddv3_human; DHRS2; CDC27; CDC27; TK2; BRINP1; SORBS3; PROSC; ECD; p27958-pro_0000037566; PRDX5; CDC27; RRM2; PRDX2; NEK2; VBP1; PRDX1; CDC20; CDC16; GNPTAB
- Q&As
- Reviews
Q&As (17)
Ask a questionCurrently, ANAPC15 has not been established as a diagnostic or prognostic marker for any diseases. However, as research on ANAPC15 progresses, its potential as a biomarker may be explored in the future for certain diseases or disorders.
ANAPC15 is known to interact with other subunits of the APC/C complex, such as ANAPC2, ANAPC5, and ANAPC16. These interactions are crucial for the formation and functioning of the APC/C complex in regulating the cell cycle.
To date, there have been no known inherited disorders specifically associated with ANAPC15 mutations. However, it is worth noting that mutations in other subunits of the APC/C complex have been linked to developmental disorders and certain cancers. Therefore, it is possible that ANAPC15 mutations may also have implications in inherited disorders, but further research is required to establish any direct associations.
As ANAPC15 is part of a larger protein complex, targeting it specifically may be challenging. However, the APC/C complex and its subunits, including ANAPC15, play critical roles in regulating the cell cycle, making them potential targets for therapeutic interventions in diseases such as cancer. Developing small molecules or targeted therapies that modulate the activity of the APC/C complex may have therapeutic potential, but more research is needed in this area.
ANAPC15 has been shown to interact with several other subunits of the APC/C complex, such as ANAPC2, ANAPC5, and ANAPC16. These interactions are crucial for the assembly and stability of the APC/C complex. Additionally, ANAPC15 may interact with specific target proteins that are being ubiquitinated by the APC/C complex, although the specific binding partners of ANAPC15 in this context have not been extensively studied.
At present, there is limited information on the potential use of ANAPC15 expression as a biomarker for disease prognosis. However, studies have indicated that dysregulation of other subunits of the APC/C complex is associated with poor prognosis in certain cancers. Further research is needed to determine whether ANAPC15 expression can serve as a reliable biomarker for disease prognosis in specific contexts.
As of now, there are no known drugs or therapeutic interventions that specifically target ANAPC15. However, there are drugs that indirectly affect the function of the APC/C complex and, consequently, may impact ANAPC15's activity. For example, certain chemotherapeutic drugs used in cancer treatment, such as taxanes and platinum-based compounds, can affect cell cycle progression indirectly through the APC/C complex.
The regulation of ANAPC15 expression is not well-studied at the moment. However, it is likely that the expression of ANAPC15 is controlled by various mechanisms, including transcriptional regulation, post-transcriptional modifications, and protein stability.
Currently, there is limited research on the specific role of ANAPC15 dysregulation in diseases or conditions. However, dysregulation of other subunits of the APC/C complex has been implicated in various diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. Therefore, it is plausible that ANAPC15 dysregulation may contribute to the pathogenesis of similar conditions, but further research is needed to establish any direct associations.
Existing literature does not currently report any known allelic variations or polymorphisms in ANAPC15. However, ongoing research efforts may uncover genetic variations in ANAPC15 in different populations, and larger-scale studies are needed to comprehensively assess the genetic diversity within this gene.
While ANAPC15 has not been extensively studied in the context of cancer, dysregulation or mutations in other subunits of the APC/C complex have been associated with the development and progression of various cancers. Therefore, it is possible that ANAPC15 dysregulation or mutations may also contribute to cancer development, but further research is needed to establish a direct link.
ANAPC15 is primarily known for its role in regulating the cell cycle through the APC/C complex. While it is not directly involved in DNA repair processes, the proper progression of the cell cycle, which ANAPC15 contributes to, is crucial for efficient DNA repair. Dysregulation of the cell cycle can lead to genomic instability and impaired DNA repair mechanisms, potentially contributing to the development of certain diseases, including cancer.
ANAPC15 is a subunit of the anaphase-promoting complex/cyclosome (APC/C), which is responsible for tagging specific proteins with ubiquitin for degradation by the proteasome. ANAPC15 helps to form the core structure of the APC/C complex and is involved in the recognition and binding of target proteins. Through its interaction with other subunits of the complex, ANAPC15 facilitates the ubiquitination of target proteins, leading to their subsequent degradation by the proteasome.
There is limited information available regarding the regulation or modification of ANAPC15. However, like other subunits of the APC/C complex, ANAPC15 is likely subjected to various post-translational modifications, such as phosphorylation, acetylation, or methylation, which can affect its stability and function. Future research may uncover more regulatory mechanisms and modifications that impact ANAPC15.
Currently, there is limited research on ANAPC15 itself, and therefore, the availability of animal models specifically targeting ANAPC15 is unknown. However, there are animal models available to study other subunits of the APC/C complex, which can indirectly inform our understanding of ANAPC15's function.
There is currently no direct evidence to suggest that ANAPC15 is involved in cellular apoptosis or programmed cell death. However, given its role in cell cycle regulation, it is possible that ANAPC15 indirectly affects these processes by influencing the stability and degradation of the proteins involved in apoptosis.
Currently, no specific diseases or disorders have been directly linked to mutations or dysregulation in ANAPC15. However, dysfunctions in other subunits of the APC/C complex have been associated with various diseases and cancer. Further research is needed to explore if ANAPC15 dysregulation could have similar implications.
Customer Reviews (4)
Write a reviewThey ensure a reliable and consistent supply of ANAPC15 protein, minimizing any potential disruptions in my experimental workflow.
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In addition to the impeccable protein quality, the manufacturer provides excellent technical support that can effectively address any challenges I may encounter during my experiments.
This reliable supply chain management assures that I have uninterrupted access to the protein, allowing me to plan and conduct my experiments without concern for availability issues.
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