ANAPC7
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Official Full Name
anaphase promoting complex subunit 7
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Overview
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008] -
Synonyms
ANAPC7; anaphase promoting complex subunit 7; APC7; anaphase-promoting complex subunit 7; cyclosome subunit 7;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ANAPC7-9640H | Recombinant Human ANAPC7, GST-tagged | E.coli | GST | C-term-302a.a. | |
Human | ANAPC7-547H | Recombinant Human ANAPC7 protein, GST-tagged | Wheat Germ | GST | ||
Human | ANAPC7-3228H | Recombinant Human ANAPC7 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | ANAPC7-1286HF | Recombinant Full Length Human ANAPC7 Protein, GST-tagged | In Vitro Cell Free System | GST | 503 amino acids | |
Human | ANAPC7-2084H | Recombinant Human ANAPC7 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Mouse | ANAPC7-1626M | Recombinant Mouse ANAPC7 Protein | Mammalian Cell | His | ||
Mouse | Anapc7-1623M | Recombinant Mouse Anapc7 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | ANAPC7-523M-B | Recombinant Mouse ANAPC7 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ANAPC7-523M | Recombinant Mouse ANAPC7 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | ANAPC7-6323Z | Recombinant Zebrafish ANAPC7 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ANAPC7 Related Articles
ANAPC7 involved in several pathways and played different roles in them. We selected most pathways ANAPC7 participated on our site, such as Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell cycle | POT1A;ANAPC11;ENSA;SMARCA5;SGOL1;TERF2;NCAPD3;TEX12;ARPP19A |
Oocyte meiosis | MAPK1;CAMK2G;CALM2A;PRKACBA;ANAPC5;CDC27;PPP2R5EA;CAMK2A;RPS6KA3A |
Ubiquitin mediated proteolysis | UBE2W;UBE2L3A;SOCS1;BIRC8;RCHY1;UBE3C;BTRC;CUL3B;UBE2QL1 |
Progesterone-mediated oocyte maturation | MAPK8;HSP90AA1.1;PLK1;ANAPC5;GNAI1;PIK3R2;MAPK10;RAF1B;IGF1R |
HTLV-I infection | TERT;PRKACA;RANBP1;PDGFRB;CDC20;CDC23;IL15;TNFRSF13C;PTTG2 |
ANAPC7 has several biochemical functions, for example, protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC7 itself. We selected most functions ANAPC7 had, and list some proteins which have the same functions with ANAPC7. You can find most of the proteins on our site.
Function | Related Protein |
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protein phosphatase binding | CDH2;PARD3;VCP;STAT6;JUP;KAT2A;HSP90B1;SHOC2;CDH5 |
ANAPC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC7.
BUB1B; Cdc23; Cdc16; Cdc26; Anapc16; Cdc20; CDC23; Cdk1; CDC16
- Q&As
- Reviews
Q&As (12)
Ask a questionANAPC7 contains several WD40 repeat domains, which are involved in mediating protein-protein interactions. These repeats contribute to the overall structure and stability of the APC/C complex, enabling its proper functioning.
Yes, as a subunit of the APC/C complex, ANAPC7 interacts with various other proteins. It interacts with other subunits of the APC/C complex, facilitating its assembly and stability. It also interacts with specific target proteins, as well as other cell cycle regulators, to coordinate efficient protein degradation and cell cycle progression.
As of now, there are no ongoing clinical trials specifically targeting ANAPC7 or the APC/C complex. However, the importance of the APC/C complex in cell cycle regulation and its potential as a therapeutic target is an active area of research, and it is possible that clinical trials may emerge in the future.
Currently, there are no specific therapeutic interventions targeting ANAPC7. However, the APC/C complex, including ANAPC7, represents a potential target for the development of novel anti-cancer therapies. Modulating the activity or stability of the complex could have implications in the treatment of certain malignancies.
ANAPC7 has been implicated in various diseases and disorders, particularly cancer. Dysregulation of the APC/C complex can lead to aberrant cell cycle regulation and contribute to the development and progression of cancer. ANAPC7 mutations or alterations may be associated with specific cancer subtypes, but further research is necessary to understand its exact role in disease pathogenesis.
While specific inhibitors or modulators of ANAPC7 are not currently available, researchers are actively studying the APC/C complex, including ANAPC7, to identify potential small molecules or drugs that can modulate its activity. Targeting the APC/C complex may have therapeutic implications, particularly in the context of cancer treatment.
Yes, ANAPC7, like other subunits of the APC/C complex, can undergo post-translational modifications that affect its activity and stability. For example, phosphorylation of ANAPC7 has been shown to regulate APC/C complex assembly and function. Other modifications, such as ubiquitination or acetylation, may also play a role in modulating ANAPC7's activity.
While ANAPC7 has been suggested to be dysregulated in certain types of cancer, its specific role as a biomarker for diagnosis or prognosis is still being investigated. Further research is needed to determine its potential value as a clinical biomarker in cancer or other diseases.
Yes, ANAPC7 is essential for the regulation of the cell cycle. It is a part of the APC/C complex, which performs critical functions during different phases of the cell cycle, including the initiation of mitosis and exit from mitosis. ANAPC7, along with other subunits, helps ensure the timely progression of the cell cycle.
Currently, there are no known genetic disorders specifically associated with ANAPC7 mutations. However, dysregulation of the APC/C complex, in which ANAPC7 is a part, has been implicated in various genetic disorders and diseases, including certain types of cancer.
ANAPC7 is expressed in various tissues throughout the body, indicating its involvement in essential cellular processes. However, the exact expression patterns and levels of ANAPC7 in different normal tissues have not been extensively characterized.
To my knowledge, there are no specific animal models that have been generated with ANAPC7 knockout or overexpression. However, animal models with altered expression or function of other APC/C subunits have been created to study the role of the complex in cell cycle regulation, development, and diseases.
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