ANKHA
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ANKHA-3339Z | Recombinant Zebrafish ANKHA | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ANKHA involved in several pathways and played different roles in them. We selected most pathways ANKHA participated on our site, such as Miscellaneous transport and binding events, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Miscellaneous transport and binding events | EPB49;ANKHB;ADD1;MRS2;ANKHA;AZGP1;ADD3B;ADD3A;ANKH |
Transmembrane transport of small molecules | MMGT1;CLIC2;SLC43A2;ANO4;SLC6A1A;SLC9A6A;SLC38A3A;TTYH3B;SLC24A5 |
ANKHA has several biochemical functions, for example, phosphate ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKHA itself. We selected most functions ANKHA had, and list some proteins which have the same functions with ANKHA. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
phosphate ion transmembrane transporter activity | ANKH;ANKHA;SLC17A1;ANKHB |
ANKHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKHA here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKHA.
- Q&As
- Reviews
Q&As (10)
Ask a questionThe ANKHA protein is not exclusive to humans. It is highly conserved among vertebrates, meaning that it is found in other species as well. Orthologs of the ANKHA protein, with similar functions and structures, have been identified in various organisms, including mammals, birds, reptiles, and fish.
Yes, mutations in the ANKHA gene have been associated with a rare hereditary disorder called familial chondrocalcinosis, also known as calcium pyrophosphate deposition disease (CPPD). In this condition, there is an abnormal accumulation of calcium pyrophosphate crystals in the joints, leading to inflammation, pain, and joint damage.
ANKHA gene mutations are rare in the general population. However, specific mutations in the gene have been identified in individuals with familial chondrocalcinosis. The prevalence of ANKHA gene mutations in this condition varies depending on the population studied.
Yes, researchers have utilized animal models, such as mice and zebrafish, to study ANKHA protein function and associated diseases. By genetically modifying these animals or inducing targeted mutations in the ANKHA gene, scientists can investigate the effects of ANKHA dysfunction on skeletal and joint health. Additionally, cell culture studies using human and animal cell lines have been employed to investigate ANKHA protein function and its interaction with other molecular components involved in mineralization processes.
Yes, research is ongoing to better understand the role of the ANKHA protein in mineralization processes and its implications for disease development. Scientists are investigating potential therapeutic strategies that target ANKHA function, such as identifying compounds that can modulate PPi levels or studying gene therapy approaches to correct ANKHA gene mutations. However, it's important to note that research in this area is still in the early stages, and more studies are needed to develop effective treatments.
While ANKHA gene mutations are primarily associated with familial chondrocalcinosis, mutations in other genes involved in pyrophosphate metabolism or joint health may also contribute to the development of related disorders. For example, mutations in the ANKH gene are associated with a condition called familial calcium pyrophosphate dihydrate deposition (CPPD) syndrome, which shares some similarities with familial chondrocalcinosis.
Currently, there are no specific therapeutic interventions targeted at correcting ANKHA gene mutations or directly modulating ANKHA protein function. However, lifestyle modifications can be beneficial for managing symptoms and promoting joint health. These may include maintaining a healthy weight, engaging in regular exercise that is suitable for the individual's condition, and using assistive devices or orthotics to support joints. Additionally, prompt treatment of acute flare-ups with pain relief medications and anti-inflammatory drugs can help manage symptoms.
There is ongoing research investigating the association between ANKHA gene variations and the susceptibility to certain diseases. Some studies have suggested that specific polymorphisms in the ANKHA gene may be associated with an increased risk of developing CPPD-related conditions or other joint disorders. However, more research is needed to confirm these associations and understand the precise impact of ANKHA gene variations on disease susceptibility.
Research on the ANKHA protein and its associated diseases is a relatively recent development. The identification of ANKHA gene mutations in familial chondrocalcinosis and CPPD-related conditions occurred in the late 1990s and early 2000s. Since then, studies have been conducted to understand the protein's function, regulation, and its implications for disease development. Ongoing research continues to deepen our understanding of ANKHA-related diseases and explore potential therapeutic strategies.
Currently, there are no specific therapeutic approaches targeting ANKHA-related diseases. The treatment primarily focuses on managing symptoms and slowing disease progression. This may include the use of nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, physical therapy, and, in severe cases, joint replacement surgery.
Customer Reviews (4)
Write a reviewThis reliability reduces experimental variability and enhances the accuracy of data interpretation.
Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.
They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.
Its potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.
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