ANKLE2
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Official Full Name
ankyrin repeat and LEM domain containing 2
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Synonyms
ANKLE2; ankyrin repeat and LEM domain containing 2; KIAA0692; ankyrin repeat and LEM domain-containing protein 2; LEM domain containing 7; LEMD7; FLJ22280; FLJ36132;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Mouse
- Rat
- Zebrafish
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Mouse | ANKLE2-1650M | Recombinant Mouse ANKLE2 Protein | Mammalian Cell | His | ||
Mouse | ANKLE2-536M | Recombinant Mouse ANKLE2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ANKLE2-536M-B | Recombinant Mouse ANKLE2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ANKLE2-672R | Recombinant Rat ANKLE2 Protein | Mammalian Cell | His | ||
Rat | ANKLE2-328R | Recombinant Rat ANKLE2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ANKLE2-328R-B | Recombinant Rat ANKLE2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | ANKLE2-6712Z | Recombinant Zebrafish ANKLE2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ANKLE2 involved in several pathways and played different roles in them. We selected most pathways ANKLE2 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope Reformation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKLE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell Cycle | KAT5;PMF1;CENPW;TFDP2;MAD2L2;TINF2;TGFB2;CEP76;NUPL2 |
Cell Cycle, Mitotic | MAPRE1;CENPC1;CSNK2B;ODF2;LIN52;CSNK2A1;CCP110;CP110;CETN2 |
Initiation of Nuclear Envelope Reformation | VRK2;LEMD3;TMPO;VRK1;ANKLE2 |
M Phase | KNTC1;CDCA5;NIPBL;NDC80;CTDNEP1;PDS5A;NEK7;SETA;NCAPD3 |
Mitotic Anaphase | CENPO;MIS12;CENPE;PANE1;NUDC;ZWILCH;NSL1;ERCC6L;PDS5B |
Mitotic Metaphase and Anaphase | SKA1;VRK1;LEMD3;NDC80;NUF2;CENPC1;CLIP1;SGOL1;SKA2 |
Nuclear Envelope Reassembly |
ANKLE2 has several biochemical functions, for example, protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKLE2 itself. We selected most functions ANKLE2 had, and list some proteins which have the same functions with ANKLE2. You can find most of the proteins on our site.
Function | Related Protein |
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protein phosphatase 2A binding | PPME1;PTPN1;SMG7;ENSA;MAPT;TP53;EIF4EBP1;STRN;ENSAA |
ANKLE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKLE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKLE2.
- Q&As
- Reviews
Q&As (13)
Ask a questionThe ANKLE2 protein is expressed in various tissues and organs, including the brain, liver, heart, kidney, and skeletal muscles. Its expression is particularly high in tissues with a high turnover rate, such as developing embryos and rapidly dividing cell types.
ANKLE2 mutations associated with disorders like IMAGe syndrome can be inherited in an autosomal dominant manner. This means that an affected individual has a 50% chance of passing the mutation onto their offspring. However, it is important to note that ANKLE2-related disorders are rare and mutations in the ANKLE2 gene are not commonly found in the general population. Genetic testing and counseling can help assess the risk of inheritance and provide information for family planning.
Besides its known roles in nuclear envelope organization and DNA repair, ANKLE2 has been implicated in other cellular processes. It has been shown to participate in cell cycle regulation by influencing the expression of cyclin-dependent kinase (CDK) inhibitors. ANKLE2 has also been found to play a role in the DNA damage response pathway, specifically in the activation of checkpoint kinases. Further research is needed to fully understand the extent of ANKLE2's involvement in these processes.
Given the critical roles of ANKLE2 in nuclear envelope function, DNA repair, and chromosome segregation, understanding its involvement in disease processes may have therapeutic implications. Dysregulation of ANKLE2 has been linked to certain developmental disorders and cancer progression. Targeting ANKLE2 or its interacting partners could potentially lead to novel strategies for treating these diseases. However, more research is necessary to fully explore the therapeutic potential of ANKLE2 protein.
Animal models, such as mice, have been used to study the function of ANKLE2 in development and disease. Genetic modifications that disrupt or alter ANKLE2 expression in these models can provide insights into its role in different biological processes. Cell culture systems and molecular techniques are also employed to investigate the molecular mechanisms and interactions of ANKLE2.
Currently, there are no targeted therapies available specifically for ANKLE2-related disorders. Treatment for these disorders is generally symptomatic and supportive, aiming to address the specific symptoms and complications that arise. For example, individuals with IMAGe syndrome may receive hormone replacement therapy to manage adrenal insufficiency, while skeletal abnormalities may require orthopedic interventions. Genetic counseling and early detection of potential complications are important components of managing ANKLE2-related disorders.
The regulation of ANKLE2 protein is not well understood. It is known to have multiple isoforms, which may be differentially regulated. Additionally, post-translational modifications and interacting proteins may influence its stability, localization, and activity. Further research is needed to uncover the specific regulatory mechanisms of ANKLE2.
Yes, ANKLE2 has been found to interact with various proteins and complexes. One well-characterized interaction is with the barrier-to-autointegration factor (BAF) protein, which is involved in nuclear envelope assembly and maintenance. ANKLE2 interacts with BAF to regulate nuclear envelope remodeling and chromatin organization. Additionally, ANKLE2 has been shown to interact with proteins involved in DNA repair, such as BRCA1 and Rad50, indicating its role in these cellular processes.
Due to the rarity of ANKLE2-related disorders, clinical trials and research specifically focused on these disorders are limited. However, research is ongoing to better understand the molecular mechanisms and clinical implications of ANKLE2 mutations. Additionally, studies investigating the function of ANKLE2 in cancer and other cellular processes may provide valuable insights into ANKLE2-related disorders. It is important to stay updated on current literature and research to keep track of any advancements in this field.
Yes, mutations in the ANKLE2 gene have been associated with IMAGe syndrome, as mentioned earlier. These mutations can disrupt the function of ANKLE2 and lead to the characteristic symptoms of the disorder. However, the exact mechanisms by which these mutations result in IMAGe syndrome are still being investigated. Other disease-associated mutations or dysregulation of ANKLE2 are yet to be identified and characterized.
Yes, there is evidence suggesting the involvement of ANKLE2 in cancer. Studies have found that ANKLE2 expression is elevated in certain types of cancer, including ovarian cancer, lung cancer, and pancreatic cancer. Elevated ANKLE2 expression has been associated with tumor progression and poor patient survival outcomes. The exact mechanisms through which ANKLE2 contributes to cancer development and progression are still being investigated.
As of now, there are no specific animal models available for studying ANKLE2-related disorders such as IMAGe syndrome. This lack of animal models makes it challenging to fully understand the molecular mechanisms and pathways affected by ANKLE2 mutations. However, ongoing research efforts may lead to the development of animal models in the future, which would greatly facilitate the study of ANKLE2-related disorders and potential therapeutic interventions.
Mutations in the ANKLE2 gene have been identified in individuals with a condition called IMAGe syndrome, which stands for Intrauterine growth restriction, Metaphyseal dysplasia, Adrenal hypoplasia congenita, and Genital anomalies. IMAGe syndrome is a rare disorder characterized by prenatal growth restriction, skeletal abnormalities, adrenal gland underdevelopment, and genital anomalies. ANKLE2 mutations are thought to disrupt the function of the protein, leading to the development of these symptoms.
Customer Reviews (4)
Write a reviewThis protein demonstrates exceptional performance in ELISA, delivering accurate and reliable results in the detection and quantification of specific antigens.
ANKLE2 protein has proven to be instrumental in protein electron microscopy structure analysis.
ANKLE2 protein is highly recommended for scientific research applications, especially in ELISA assays and protein electron microscopy structure analysis.
With ANKLE2 protein, researchers can visualize protein complexes and their interactions with remarkable clarity, unraveling important insights into their functional mechanisms.
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