ANKS1B
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Official Full Name
ankyrin repeat and sterile alpha motif domain containing 1B
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Overview
EB1 (end-binding protein 1) is a microtubule associated protein (1). EB1 localizes to the growing ends of microtubules, the centrosome and the mitotic spindle (2-4). EB1 is also found to associate with the adenomatous polyposis coli (APC) protein (5). Rec -
Synonyms
ANKS1B; ankyrin repeat and sterile alpha motif domain containing 1B; ankyrin repeat and sterile alpha motif domain-containing protein 1B; AIDA 1; ANKS2; cajalin 2; EB 1; E2a-Pbx1-associated protein; amyloid-beta precursor protein intracellular domain asso;
- Recombinant Proteins
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Myc
- DDK
- Myc|DDK
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ANKS1B-2649H | Recombinant Human ANKS1B Protein, GST-tagged | Wheat Germ | GST | ||
Human | ANKS1B-9678H | Recombinant Human ANKS1B, GST-tagged | E.coli | GST | 446-510a.a. | |
Human | ANKS1B-2164H | Recombinant Human ANKS1B Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | ANKS1B-3767H | Recombinant Human ANKS1B protein, His-tagged | E.coli | His | 446-510 aa | |
Human | ANKS1B-6455H | Recombinant Human ANKS1B Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | ANKS1B-3934HF | Recombinant Full Length Human ANKS1B Protein, GST-tagged | In Vitro Cell Free System | GST | 510 amino acids | |
Mouse | Anks1b-1640M | Recombinant Mouse Anks1b Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rat | Anks1b-3474R | Recombinant Rat Anks1b, His-tagged | E.Coli or Yeast | His | 1260 | |
Zebrafish | ANKS1B-5822Z | Recombinant Zebrafish ANKS1B | Mammalian Cell | His | ||
Chicken | ANKS1B-4535C | Recombinant Chicken ANKS1B | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ANKS1B involved in several pathways and played different roles in them. We selected most pathways ANKS1B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKS1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ANKS1B has several biochemical functions, for example, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKS1B itself. We selected most functions ANKS1B had, and list some proteins which have the same functions with ANKS1B. You can find most of the proteins on our site.
Function | Related Protein |
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ephrin receptor binding | SHC1;EFNB1;EFNB2A;SRC;SDCBP;EFNA1;EFNA2;PIK3CG;SIPA1L1 |
ANKS1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKS1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKS1B.
EGFR; ERBB2; ITGB3; ITGB1; ITGB7; ERBB4
- Q&As
- Reviews
Q&As (15)
Ask a questionThe potential therapeutic targeting of Anks1B has not been extensively explored. However, given its involvement in cancer progression and metastasis, it may represent a potential therapeutic target for cancer therapies aimed at inhibiting cell migration and invasion. Further research is needed to evaluate its clinical relevance and potential as a therapeutic target.
Anks1B has been shown to interact with various proteins, including β-catenin, Rho GTPases (such as RhoA and Rac1), and the actin cytoskeleton regulator ERM (Ezrin, Radixin, Moesin) proteins. These interactions suggest that Anks1B may participate in multiple signaling pathways involved in cell adhesion, migration, and cytoskeletal dynamics.
Yes, animal models and knockout studies have been conducted to investigate the role of Anks1B in development and disease. Mice with Anks1B gene knockout display defects in tissue morphogenesis and cell migration, leading to abnormalities in organ development. These studies provide valuable insights into the physiological functions of Anks1B.
Yes, Anks1B interacts with several proteins. One of its known interactors is Anks1A, forming a complex together. Anks1B also interacts with proteins such as β-catenin and LIMK1, which are involved in actin cytoskeleton regulation, and may modulate their activities.
Mutations in the Anks1B gene have been linked to certain genetic disorders, including KBG syndrome. KBG syndrome is characterized by intellectual disability, short stature, skeletal abnormalities, and distinctive craniofacial features. These mutations may lead to alterations in Anks1B protein function and disrupt its normal cellular processes, contributing to the development of these disorders.
Currently, there is no evidence to suggest that Anks1B can be used as a biomarker for specific diseases. However, its association with cancer progression and metastasis suggests that further research may explore its potential as a diagnostic or prognostic marker in certain cancer types.
Yes, Anks1B exhibits a tissue-specific expression pattern. It is found to be highly expressed in tissues that undergo active morphogenetic movements, such as developing embryos, neural tissues, and certain adult tissues including the brain, heart, and testis.
Yes, Anks1B has been implicated in cancer progression and metastasis. Studies have shown that Anks1B expression is elevated in various cancer types, including breast, colorectal, and ovarian cancers. It has been suggested that Anks1B promotes tumor cell migration and invasion through its involvement in cytoskeletal organization and cell adhesion.
Anks1B is expressed in a wide range of tissues and cell types. It is detected in various organs, including the brain, heart, liver, and skeletal muscle. Within these tissues, Anks1B expression can be localized to specific cell types, such as neurons in the brain or cardiomyocytes in the heart. The specific expression pattern of Anks1B may reflect its diverse functions in different cellular contexts.
Yes, there is evidence suggesting that Anks1B is involved in different cell signaling pathways. Anks1B has been shown to interact with β-catenin, a key component of the Wnt signaling pathway, and modulate its activity. Additionally, Anks1B has been implicated in the regulation of RhoA and Rac1 signaling, both of which play important roles in cytoskeletal dynamics and cell migration.
he molecular mechanisms underlying the functions of Anks1B are still being elucidated. However, some studies have provided insights into its roles. Anks1B has been shown to interact with β-catenin, a key component of the Wnt signaling pathway, and regulate the transcriptional activity of β-catenin in a context-dependent manner. This suggests that Anks1B may influence cell fate determination and tissue development through its involvement in Wnt signaling.
Anks1B is involved in various cellular processes, including cell adhesion, migration, and cytoskeletal organization. It interacts with proteins that regulate the actin cytoskeleton, which is essential for cell shape, movement, and intracellular transport. Anks1B also participates in signaling pathways, such as the Wnt signaling pathway, that control cell fate determination and tissue development.
Dysfunction or depletion of Anks1B can lead to various cellular defects and physiological consequences. In animal models, Anks1B knockout has been associated with abnormalities in tissue morphogenesis, skeletal development, and cell migration. These defects can have severe consequences on organ development and may contribute to the pathogenesis of certain diseases or genetic disorders.
Mutations in the ANKS1B gene have been associated with neurodevelopmental disorders, similar to the related ANKS1A gene. Variants in ANKS1B have been reported in individuals with autism spectrum disorders and intellectual disabilities, suggesting a potential role in the pathogenesis of these conditions. However, more research is needed to fully understand the impact of ANKS1B mutations on disease development.
Targeting Anks1B could have therapeutic implications, particularly in conditions or diseases where its dysregulation or dysfunction is implicated. For example, in diseases such as KBG syndrome associated with Anks1B mutations, therapeutic strategies aimed at correcting or compensating for the mutant Anks1B protein could potentially ameliorate the disease phenotype.
Customer Reviews (4)
Write a reviewthe ease of use and compatibility of the Anks1b protein with various techniques further enhances its appeal.
One of the standout features of the Anks1b protein is the excellent technical support provided by the manufacturer.
The Anks1b protein is a top-quality product that is sure to fulfill my experimental requirements.
Whether I need to study protein-protein interactions, protein localization, or protein folding, the Anks1b protein consistently delivers precise and meaningful data.
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