ANO2
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Official Full Name
anoctamin 2
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Overview
ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 (PubMed;19015192)). -
Synonyms
ANO2; anoctamin 2; C12orf3, chromosome 12 open reading frame 3 , TMEM16B, transmembrane protein 16B; anoctamin-2; transmembrane protein 16B (eight membrane spanning domains); transmembrane protein 16B (eight membrane-spanning domains); C12orf3; TMEM16B;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|T7
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ANO2-8014H | Recombinant Human ANO2 protein, His & T7-tagged | E.coli | His/T7 | Ala823~Val1003 (Accession # Q9NQ90) | |
Mouse | ANO2-1698M | Recombinant Mouse ANO2 Protein | Mammalian Cell | His | ||
Mouse | ANO2-568M | Recombinant Mouse ANO2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Ano2-157M | Recombinant Mouse Ano2 Protein, His-tagged | E.coli | N-His | Lys644-Met747 | |
Mouse | ANO2-568M-B | Recombinant Mouse ANO2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | ANO2-6154Z | Recombinant Zebrafish ANO2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ANO2 Related Articles
ANO2 involved in several pathways and played different roles in them. We selected most pathways ANO2 participated on our site, such as Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Olfactory transduction | OR51D1;CALM1;GNG13;OR6Q1;OR5K1;OR51B5;PRKG1;OR52B4;OR11A1 |
ANO2 has several biochemical functions, for example, chloride channel activity, intracellular calcium activated chloride channel activity, NOT phospholipid scramblase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANO2 itself. We selected most functions ANO2 had, and list some proteins which have the same functions with ANO2. You can find most of the proteins on our site.
Function | Related Protein |
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chloride channel activity | TTYH2;CLCA4;GABRE;GABRA1;SLC26A2;SLC26A3.1;APOL1;SLC26A11;SLC26A1 |
intracellular calcium activated chloride channel activity | ANO6;CLCA2;ANO4;ANO2;TTYH3;ANO7;NMUR2;ANO8;CLCA1 |
NOT phospholipid scramblase activity | ANO10;ANO2;ANO5 |
protein binding | TBATA;FBXL3;CORO1A;HSPA4;ARNTL1B;KIF1B;MT1A;CCDC170;RPA2 |
protein heterodimerization activity | HIST1H2B5;H2AFVB;TAS1R2;OSTA;SOX17;CEBPB;HOMER2;CLCF1;FZD1 |
protein homodimerization activity | MAP3K11;SLC30A8;SLC9A7;MSH2;PFKM;CUL3;CAMK2D;GSTM1;BAXB |
ANO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANO2.
- Q&As
- Reviews
Q&As (18)
Ask a questionYes, ANO2 protein can be regulated by calcium signaling. It contains calcium-binding sites that allow it to be activated by increases in intracellular calcium levels. The binding of calcium ions to ANO2 leads to conformational changes that open the channel, allowing chloride ion currents to flow.
Mutations in the ANO2 gene have been associated with certain neurological disorders. For example, mutations in ANO2 have been linked to autosomal dominant craniocervical dystonia (CD), a movement disorder characterized by involuntary muscle contractions affecting the head and neck.
Yes, ANO2 protein can interact with other proteins. For example, it has been shown to physically associate with other ion channels and regulatory proteins, such as the inositol-trisphosphate receptor (IP3R) and the calcium-activated potassium channel, KCa2.3. These interactions may have important functional implications in cellular signaling and physiological processes.
Several compounds have been identified as modulators of ANO2 activity. For example, the natural compound tannic acid and certain synthetic compounds like benzbromarone have been shown to inhibit ANO2 function. These compounds can serve as tools for further elucidating ANO2's function and potential as therapeutic targets.
Currently, there are no FDA-approved drugs specifically targeting ANO2 protein. However, ongoing research is focused on identifying compounds that can modulate ANO2 function and potentially be used therapeutically in conditions associated with ANO2 dysfunction.
Researchers use a variety of techniques to study ANO2 protein, including genetic and molecular biology approaches, electrophysiology, immunohistochemistry, and imaging techniques. Patch-clamp electrophysiology, for example, is a common method used to investigate the electrical activity of ANO2 channels and their properties.
Yes, ANO2 protein has been implicated in cell migration. It has been found to regulate cell migration in certain cell types, such as glioblastoma cells and cancer-associated fibroblasts. ANO2 activity can influence processes like cell adhesion, actin cytoskeleton remodeling, and cell protrusion formation, which are critical for cell migration.
Yes, ANO2 protein is involved in cell volume regulation. It is a calcium-activated chloride channel that can mediate chloride ion influx or efflux, depending on the cellular context. This activity helps maintain proper cell volume under different physiological conditions.
There is evidence suggesting that ANO2 protein may play a role in neurotransmitter release. It has been detected in presynaptic terminals of neurons and has been shown to modulate calcium-dependent exocytosis in certain cell types. However, the exact mechanisms and significance of ANO2 in neurotransmitter release require further investigation.
ANO2 protein is expressed in various tissues throughout the body, but it is particularly abundant in the brain, specifically in regions involved in movement control and sensory processing. It is also found in the respiratory system, gastrointestinal tract, reproductive organs, and other tissues.
Currently, there are no FDA-approved drugs that specifically target ANO2 protein. However, ongoing research is focused on developing selective ANO2 inhibitors or modulators for potential therapeutic interventions.
ANO2 protein has been found to be expressed in sensory neurons involved in pain perception. Studies suggest a potential role for ANO2 protein in regulating pain sensitivity, although more research is needed to fully understand its involvement in this process.
Yes, ANO2 protein can be regulated by phosphorylation, which is the addition of a phosphate group to specific amino acid residues. Phosphorylation can either enhance or inhibit ANO2 function, depending on the specific phosphorylation site and the signaling pathways involved.
The potential therapeutic targeting of ANO2 protein is an active area of research. Modulating ANO2 activity may have implications in conditions such as movement disorders, hearing impairment, and pain management. However, more studies are required to develop specific and effective therapeutic interventions targeting ANO2.
Yes, mutations in ANO2 gene have been associated with certain disorders. For instance, mutations in ANO2 have been linked to autosomal dominant craniocervical dystonia type 3 (DYT25), a movement disorder characterized by involuntary muscle contractions in the head and neck region.
ANO2 has been explored as a potential therapeutic target for various conditions. Inhibition of ANO2 activity has been suggested as a potential treatment for disorders involving excessive neuronal excitability and muscle spasms.
Besides craniocervical dystonia (CD), ANO2 protein has also been implicated in other disorders. Studies have suggested potential involvement of ANO2 in disorders related to hearing, such as congenital deafness, and in sensory processes like olfaction. However, further research is needed to fully understand the role of ANO2 protein in these conditions.
Yes, ANO2 protein has been implicated in the regulation of cilia function. Cilia are specialized cellular structures that play crucial roles in sensing environmental cues and cellular signaling. ANO2 channels have been found in cilia of various cell types and have been shown to modulate ciliary beat frequency, which is important for proper cilia function.
Customer Reviews (4)
Write a reviewIt enables accurate detection and quantification of ANO2 protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.
ANO2 (Anoctamin 2) protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.
ANO2 protein has shown great utility in protein electron microscopy structure analysis.
The use of ANO2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.
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