ANXA2A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ANXA2A-9639Z | Recombinant Zebrafish ANXA2A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ANXA2A involved in several pathways and played different roles in them. We selected most pathways ANXA2A participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Dissolution of Fibrin Clot | HRG;ANXA2;SERPINE2;S100A10A;SERPINF2B;ANXA2B;ANXA2A;S100A10;SERPINB8 |
Hemostasis | BA1;SLC7A11;HBB-BH1;PLEK;KLC3;DOCK6;Alb;MGC173646;PIK3R6 |
ANXA2A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA2A itself. We selected most functions ANXA2A had, and list some proteins which have the same functions with ANXA2A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
calcium ion binding | ANXA8;PCDHA2;PCDH2G1;SLC24A5;EHD1;CASQ1B;PCDH2G12;OTOF;S100A10B |
calcium-dependent phospholipid binding | SYT11A;SYT5B;ANXA3;SYT2;ANXA11;DOC2D;SYT15;ANXA11B;SYT5 |
cytoskeletal protein binding | ABI1;MYPN;FARP2;MSNA;PTPN3;EZRB;NEBL;ANXA2A;ANXA2B |
phospholipase inhibitor activity | ANXA2B;ANGPTL3;ANXA1B;ANXA5;SNCB;ANXA4;ANXA2A;ANXA3B;ANXA3A |
ANXA2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA2A.
- Q&As
- Reviews
Q&As (10)
Ask a questionANXA2A promotes tumor invasion and metastasis through multiple mechanisms. It is involved in the formation of invadopodia, which are protrusive structures on the surface of cancer cells that facilitate matrix degradation and invasion. ANXA2A interacts with actin filaments and regulates the assembly and stability of invadopodia, promoting their formation and function.
There have been reports of genetic alterations and mutations in the ANXA2A gene associated with certain diseases. For example, mutations in ANXA2A have been observed in individuals with idiopathic dilated cardiomyopathy, a condition characterized by weakened heart muscle function. However, the understanding of the specific role of ANXA2A mutations in disease development is still being investigated.
ANXA2A interacts with different proteins and molecules to carry out its functions. It can bind to actin filaments, enabling its involvement in cytoskeleton organization and cell motility processes. ANXA2A also interacts with other annexin family members, such as ANXA1 and ANXA5. Additionally, it can form complexes with various membrane receptors, integrins, and proteins involved in vesicle trafficking.
ANXA2A has emerged as a potential target for cancer therapy due to its involvement in tumor progression and metastasis. Several strategies have been explored to target ANXA2A in preclinical studies. These include inhibiting ANXA2A expression using siRNAs or antisense oligonucleotides, blocking ANXA2A receptor interactions using small molecules or antibodies, and disrupting ANXA2A-actin interactions.
ANXA2A has been implicated in neurodegenerative diseases other than Alzheimer's disease. It has been found to be upregulated in Parkinson's disease and Huntington's disease, suggesting its potential involvement in the pathogenesis of these conditions. ANXA2A may contribute to the accumulation of misfolded proteins and neuroinflammation in neurodegenerative diseases.
ANXA2A has been proposed as a potential biomarker for cancer due to its dysregulated expression in various types of cancer. Increased ANXA2A expression has been associated with poor prognosis in certain cancers, such as breast, lung, colorectal, and ovarian cancers. However, further research is needed to validate ANXA2A as a reliable biomarker for cancer diagnosis and prognosis.
Yes, ANXA2A has been implicated in various diseases. It is often overexpressed in cancer cells and has been associated with increased invasion, metastasis, and drug resistance. ANXA2A has also been implicated in neurodegenerative diseases, including Alzheimer's disease, where it may contribute to amyloid plaque formation. Additionally, ANXA2A has been linked to cardiovascular diseases, inflammation, and autoimmune disorders.
Yes, ANXA2A is involved in cellular signaling pathways. It can modulate the activity of protein kinases, including protein kinase C (PKC) and tyrosine kinases, and participate in intracellular signaling cascades. ANXA2A's involvement in signaling pathways can vary depending on the cellular context and its interacting partners.
ANXA2A is often overexpressed in cancer cells and plays a significant role in cancer progression. It has been implicated in tumor invasion, metastasis, and angiogenesis. ANXA2A promotes cancer cell migration by interacting with actin filaments and regulating the formation of invadopodia, which are specialized structures that allow cancer cells to degrade extracellular matrix and invade surrounding tissues. ANXA2A also interacts with membrane receptors and integrins, promoting adhesion and migration of cancer cells. Additionally, ANXA2A has been shown to play a role in drug resistance, potentially making it a therapeutic target in cancer treatment.
The development of specific inhibitors targeting ANXA2A is still ongoing. However, certain molecules have been found to inhibit ANXA2A functions indirectly. For example, some compounds that inhibit protein kinase C (PKC) have been shown to disrupt ANXA2A phosphorylation and its interaction with other proteins. ANXA2A-associated processes, such as cancer cell migration and invasion, have also been targeted using approaches like small interfering RNAs (siRNAs) to specifically knockdown ANXA2A expression.
Customer Reviews (4)
Write a reviewNot only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.
Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the ANXA2A protein in their studies, knowing that they have the necessary resources and assistance to succeed.
This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.
the ANXA2A protein offers numerous advantages in trials and research experiments.
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