APOA1A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | APOA1A-8751Z | Recombinant Zebrafish APOA1A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
APOA1A involved in several pathways and played different roles in them. We selected most pathways APOA1A participated on our site, such as PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
PPAR signaling pathway | ADIPOQB;ME1;ILK;APOA1A;CYP8B1;SCP2A;OLR1;FABP7;SLC27A1B |
APOA1A has several biochemical functions, for example, cholesterol binding, cholesterol transporter activity, high-density lipoprotein particle binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA1A itself. We selected most functions APOA1A had, and list some proteins which have the same functions with APOA1A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
cholesterol binding | NPC2;PMP2;APOF;STARD3;OSBP2;CYP11A1;PTCH1;SYP;APOC3 |
cholesterol transporter activity | APOA1;ABCA4A;ABCA4;APOA1A;APOA4B.2;ABCA1B;STAR;APOB;APOE |
high-density lipoprotein particle binding | APOA1;GPIHBP1;APOA2;APOL2;APOA1A |
lipid binding | ALOX8;BPIFB7;FAM123A;BAD;PACSIN1B;PAQR7B;FABP1B.1;FAM123C;PFN4 |
lipid transporter activity | GM2A;APOBB.1;APOC4;MTTP;APOA4;VTG4;VTG5;VTG1;APOF |
phosphatidylcholine binding | RASGRP1;ESYT2;NF1;APOA4A;APOA1;APOA2;CHMP2A;VPS24;GPR119 |
phosphatidylcholine-sterol O-acyltransferase activator activity | APOA4B.1;APOA5;APOA2;APOA1;APOC1;APOEB;APOE;APOA1A;APOA4 |
APOA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA1A.
- Q&As
- Reviews
Q&As (18)
Ask a questionResearch related specifically to therapeutic interventions targeting APOA1A protein may be limited. However, various studies focus on understanding the role of APOA1 and HDL metabolism in cardiovascular health. Therapies aimed at raising HDL levels, such as lifestyle modifications and pharmacological interventions, are areas of ongoing research.
Currently, APOA1A levels are not commonly used to predict the response to lipid-lowering therapy. Instead, other markers such as LDL cholesterol levels and genetic markers like the presence of certain gene variants are used to guide treatment decisions and assess the effectiveness of lipid-lowering therapies. However, ongoing research may shed light on the potential use of APOA1A levels as predictive markers in the future.
Currently, there are no drugs or medications specifically designed to target the APOA1A protein. However, there are medications available that can indirectly impact APOA1A levels and HDL functionality. These include statins, fibrates, and niacin, which can help increase HDL levels and promote cardiovascular health.
The APOA1A protein is a specific variant or isoform of the APOA1 protein. It may have slight differences in its genetic sequence or structure compared to the regular APOA1 protein, but it still performs similar functions in lipid transport and cardiovascular health.
Yes, there are genetic disorders associated with mutations in the APOA1A protein. One such disorder is familial amyloidosis, in which mutations in the APOA1 gene can lead to the accumulation of amyloid protein deposits in various organs, including the kidneys, liver, and heart. This condition can result in organ dysfunction and can be inherited in an autosomal dominant manner.
Currently, there are no specific drugs or interventions known to directly increase APOA1A levels. However, lifestyle modifications such as regular exercise, a healthy diet, and weight loss have been shown to increase HDL levels, which may indirectly affect APOA1A levels. Additionally, certain medications like statins, fibrates, and niacin can help increase HDL levels and may impact APOA1A levels.
Dysfunctional or deficient APOA1A protein is not known to cause specific diseases. However, alterations in APOA1 protein levels or functionality can contribute to conditions like familial hypoalphalipoproteinemia, characterized by low HDL cholesterol levels and an increased risk of cardiovascular diseases.
The APOA1A protein is a variant of the APOA1 protein and is generally present in all individuals; however, specific genetic variations may lead to differences in APOA1A isoform expression across different populations. The expression levels can also differ depending on genetic and environmental factors.
Hormone levels can influence APOA1A levels to some extent. Estrogen, for example, has been shown to increase APOA1A levels and promote HDL synthesis. In postmenopausal women, when estrogen levels decrease, there is often a decline in APOA1A levels and HDL functionality. Similarly, testosterone has been found to impact HDL metabolism and APOA1A levels in men. However, the exact mechanisms and effects of various hormones on APOA1A levels are still being explored.
While the primary role of APOA1A is related to lipid metabolism, there is emerging evidence suggesting a potential association between APOA1A and neurological disorders. Some studies have found links between APOA1A mutations and an increased risk of Alzheimer's disease, stroke, and cognitive decline. However, further research is needed to fully understand the role of APOA1A in these neurological conditions.
While the primary function of the APOA1A protein is related to lipid metabolism and its role in HDL particles, it may also have additional functions. Some studies suggest that APOA1A could have anti-inflammatory properties, antioxidant effects, and potential involvement in immune regulation, although further research is needed to fully understand these roles.
Yes, lifestyle changes can have an impact on APOA1A levels and functionality. Regular exercise, a healthy diet, weight loss, and avoiding smoking can help increase HDL levels and improve the overall functionality of the APOA1A protein. These lifestyle modifications are known to promote cardiovascular health and may positively influence HDL metabolism.
While there may be genetic variations within the APOA1 gene, resulting in different isoforms like APOA1A, there may not be specific mutations or variants directly linked to APOA1A. However, alterations in the APOA1 gene can affect HDL cholesterol levels and, consequently, cardiovascular health.
There is ongoing research on the APOA1A protein and its role in lipid metabolism and cardiovascular health. Researchers are studying its interactions with other proteins and lipids, exploring its potential as a therapeutic target for cardiovascular diseases, and investigating its additional functions beyond lipid metabolism. Novel approaches, such as gene therapies and targeted drug development, are also being explored to modulate APOA1A levels and improve its functionality.
APOA1A protein, as a component of HDL particles, is involved in the process of reverse cholesterol transport. It helps remove excess cholesterol from arteries and peripheral tissues, preventing the accumulation of plaque. This process reduces the risk of cardiovascular diseases, such as atherosclerosis and coronary artery disease.
The APOA1A protein interacts with various other proteins and lipids to perform its functions. It associates with enzymes, receptor proteins, and other apolipoproteins to facilitate lipid metabolism and transport. It also interacts with phospholipids, cholesterol, and triglycerides, forming the core structure of HDL particles. These interactions are crucial for the formation and function of HDL particles in lipid metabolism.
Although APOA1A protein variations can affect HDL levels and cardiovascular health, it is not commonly used as a specific biomarker for cardiovascular diseases. Instead, other markers such as total cholesterol, LDL cholesterol, and HDL cholesterol levels are more commonly used to assess cardiovascular risk. However, APOA1A levels can be measured in research settings to understand HDL metabolism and its impact on cardiovascular health.
APOA1A levels are not commonly measured in clinical settings. Instead, total cholesterol, HDL cholesterol, and LDL cholesterol levels are typically measured as primary markers of cardiovascular risk. However, in research settings, APOA1A levels can be measured using laboratory techniques such as immunoassays or mass spectrometry.
Customer Reviews (4)
Write a reviewTheir expertise and prompt assistance have been instrumental in overcoming challenges and optimizing the use of the APOA1A protein in my studies.
Its purity and consistency have consistently generated trustworthy and reproducible results in my research.
the manufacturer's commitment to delivering excellent technical support has proven to be invaluable in troubleshooting any issues that arose during my experiments.
I am extremely satisfied with the high performance and the exceptional support associated with this protein, as it has greatly contributed to the success of my scientific endeavors.
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