APOER2
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | APOER2-8164Z | Recombinant Zebrafish APOER2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- APOER2 Related Research Area
APOER2 involved in several pathways and played different roles in them. We selected most pathways APOER2 participated on our site, such as Hemostasis, Platelet homeostasis, Platelet sensitization by LDL, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOER2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Hemostasis | KIF20A;G6b;CFHL1;CD9B;TRPC7;KIF3C;HBD;MAFG;PRTN3 |
Platelet homeostasis | KCNMA1;APOER2;ATP2B3A;SLC8A2A;KCNMB1;KCNMB2;ATP2B1B;PDE10A |
Platelet sensitization by LDL |
APOER2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by APOER2 itself. We selected most functions APOER2 had, and list some proteins which have the same functions with APOER2. You can find most of the proteins on our site.
Function | Related Protein |
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APOER2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOER2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOER2.
- Q&As
- Reviews
Q&As (14)
Ask a questionResearchers are utilizing various strategies to further understand APOER2 and its functions. These include genetic studies to identify APOER2-related genetic variants, in vitro and in vivo studies to investigate its molecular interactions, animal models to study APOER2 function in disease contexts, and advanced imaging techniques to visualize APOER2 localization and activity.
Yes, there are genetic variations in the APOER2 gene that can impact its function. Single nucleotide polymorphisms (SNPs) in the APOER2 gene have been associated with altered risk and severity of Alzheimer's disease and other neurological conditions.
Currently, there are no specific drugs or therapeutic approaches targeting APOER2. However, ongoing research on the role of APOER2 in neurological disorders may lead to the development of potential targeted therapies in the future.
APOER2 and its associated pathways are potential therapeutic targets for neurodegenerative disorders. Modulating APOER2 function or its interactions with other proteins could potentially be used to promote amyloid-beta clearance and improve synaptic plasticity in Alzheimer's disease.
The expression of APOER2 can be regulated by various factors, including transcriptional mechanisms and epigenetic modifications. Additionally, certain signaling pathways and molecules can influence the expression levels of APOER2.
While the primary focus of APOER2 research has been on neurological disorders, emerging evidence suggests that its dysfunction may also contribute to other diseases. For example, APOER2 has been associated with cardiovascular diseases, metabolic disorders, and cancers, highlighting its potential involvement in various pathological conditions.
APOER2 has been implicated in various neurological disorders, including Alzheimer's disease and synaptic plasticity disorders. It is involved in processes such as neuronal development, maintenance of synaptic connections, and the clearance of toxic protein aggregates.
Yes, certain mutations or deletions in the APOER2 gene have been identified. For example, a mutation known as the APOER2 R952H variant has been associated with an increased risk of Alzheimer's disease. Additionally, rare homozygous deletions of the APOER2 gene have been observed in individuals with neurodevelopmental disorders.
Yes, APOER2 has been found to be involved in various cellular processes beyond lipid metabolism and synaptic plasticity. It has been implicated in cell signaling pathways, cell adhesion, receptor endocytosis, and neuronal development. Further research is being conducted to explore its broader functions.
Yes, APOER2 is expressed in various tissues throughout the body, including the liver, heart, and skeletal muscles. Its role in these tissues is primarily related to lipid metabolism and transport.
APOER2 is involved in the clearance of amyloid-beta, a protein fragment that forms plaques in Alzheimer's disease. It binds to amyloid-beta and aids in its removal from the brain, reducing the risk of plaque formation.
The expression of APOER2 is tightly regulated during brain development. It is initially expressed in neuronal precursor cells and continues to be expressed in mature neurons. Various signaling pathways, transcription factors, and epigenetic mechanisms influence the temporal and spatial expression of APOER2 during different stages of brain development.
Yes, APOER2 can interact with several other proteins and receptors, including the low-density lipoprotein receptor-related protein 1 (LRP1) and N-methyl-D-aspartate receptors (NMDARs). These interactions are important for mediating various cellular processes.
APOER2 plays a role in lipid metabolism and transport by facilitating the internalization and processing of lipoproteins, such as APOE-containing lipoproteins. It helps to control the levels of circulating lipids and contributes to their uptake and metabolism by cells.
Customer Reviews (4)
Write a reviewTheir knowledgeable and responsive team of experts is readily available to provide guidance, troubleshooting assistance, and answer any inquiries or concerns I may have.
They ensure a reliable and consistent supply of APOER2 protein, minimizing any potential disruptions in my experimental workflow.
Whether it involves experimental design, protocol optimization, or data analysis, their expertise can help me navigate through complexities, saving valuable time and resources.
In addition to providing impeccable protein quality, the manufacturer offers excellent technical support that can effectively address any challenges I may encounter during my research.
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