APPBP2
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Official Full Name
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
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Overview
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene. -
Synonyms
APPBP2; amyloid beta precursor protein (cytoplasmic tail) binding protein 2; amyloid protein-binding protein 2; Hs.84084; KIAA0228; PAT1; protein interacting with APP tail 1; Amyloid protein binding protein 2; APP BP2; APP-BP2; amyloid beta precursor protein-binding protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
APPBP2 involved in several pathways and played different roles in them. We selected most pathways APPBP2 participated on our site, such as Regulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with APPBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Regulation of Androgen receptor activity | SRY;HOXB13;KAT7;NR0B1;NR2C1;SMARCE1;SMARCA2;NR2C2;TRIM24 |
APPBP2 has several biochemical functions, for example, microtubule motor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APPBP2 itself. We selected most functions APPBP2 had, and list some proteins which have the same functions with APPBP2. You can find most of the proteins on our site.
Function | Related Protein |
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microtubule motor activity | KLC1A;KIFC3;KIF13B;KIF1B;DNALI1;SMC1A;KIF7;DYNC1H1;CENPE |
protein binding | MEF2C;ENTPD3;RNH1;NFKBIL1;SRGAP2;SERP1;CHMP2B;PI4K2A;APOA1BP |
APPBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APPBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APPBP2.
FSTL1; TBL3; RRS1; WDR24; NFYA
- Q&As
- Reviews
Q&As (17)
Ask a questionAPPBP2 has been reported to have additional functions beyond Alzheimer's disease. It is involved in various cellular processes such as neuronal development, synaptic function, and gene transcription. Additionally, it interacts with other proteins to regulate different signaling pathways in the brain. Its role in these processes warrants further investigation.
Dysregulation of APPBP2 or alterations in its interactions with other proteins can disrupt normal cellular processes, potentially leading to neurological disorders. Dysfunction of APPBP2 has been implicated in Alzheimer's disease and other neurodegenerative conditions, highlighting its significance in maintaining proper brain function.
Research is ongoing to assess the potential of APPBP2 as a diagnostic biomarker for neurodegenerative diseases. Its detection in cerebrospinal fluid suggests it may have diagnostic utility, but further studies are needed to establish its sensitivity, specificity, and reliability as a diagnostic tool.
Besides interacting with APP, APPBP2 has been found to interact with proteins such as APLP1 (Amyloid precursor-like protein 1), APLP2, Mint/X11 proteins, JIP1, and JIP2. These interactions contribute to the regulation of APP processing, synaptic function, and neuronal development.
APPBP2 represents a potential therapeutic target for Alzheimer's disease due to its involvement in APP processing and amyloid beta production. However, more research is needed to fully elucidate the mechanisms and determine the feasibility of targeting APPBP2 for therapeutic interventions.
APPBP2 is widely expressed in various tissues throughout the body, but it is particularly abundant in the brain. Its high expression in the brain highlights its potential importance in neuronal function and neurodegenerative diseases like Alzheimer's.
APPBP2 plays a role in the processing of amyloid precursor protein (APP), which is central to the formation of amyloid-beta plaques, a hallmark of Alzheimer's disease. APPBP2 interacts with APP and regulates its degradation, metabolism, and trafficking. Dysregulation of APPBP2 can lead to increased production of toxic forms of amyloid-beta, contributing to the pathogenesis of Alzheimer's.
The potential of targeting APPBP2 for therapeutic interventions in Alzheimer's disease is being investigated. Modulating APPBP2's interactions with APP and other proteins involved in APP processing could be a strategy to reduce the production of amyloid-beta or enhance its clearance. However, more research is needed to validate this approach and explore its safety and efficacy.
APPBP2 has been implicated in other neurodegenerative diseases besides Alzheimer's, including Parkinson's disease and Huntington's disease. It interacts with proteins involved in the pathogenesis of these diseases and may contribute to their progression. Further research is needed to fully understand the role of APPBP2 in these conditions.
Some genetic studies have identified variants in the APPBP2 gene that may be associated with an increased risk of developing Alzheimer's disease. However, further research is needed to fully understand the implications of these genetic variations and their relationship to the disease.
APPBP2 interacts with the cytoplasmic domain of APP and influences its trafficking and processing. It can facilitate the internalization of APP, affecting its subsequent cleavage by secretases, enzymes that generate amyloid beta peptides.
The exact role of APPBP2 in Alzheimer's disease is not completely understood. However, studies have suggested that alterations in APPBP2 expression or function may contribute to the pathogenesis of the disease. Dysregulation of APPBP2 could potentially affect APP processing, leading to the accumulation of amyloid beta peptides, a hallmark of Alzheimer's disease.
Studies have shown that APPBP2 levels can be measured in cerebrospinal fluid, suggesting its potential as a biomarker for neurodegenerative diseases. However, more research is needed to validate its utility as a diagnostic or prognostic biomarker.
At present, there are limited clinical trials specifically targeting APPBP2 for therapeutic purposes. However, ongoing research aims to further understand the role of APPBP2 in Alzheimer's disease and explore its potential as a therapeutic target.
Several techniques can be used to study APPBP2, including co-immunoprecipitation assays, proximity-dependent labeling methods, live-cell imaging, knockout or knockdown experiments, and biochemical assays to assess protein-protein interactions and functional consequences.
While there are currently no well-established genetic variations or mutations in APPBP2 directly associated with neurodegenerative diseases, altered expression levels and functional changes in APPBP2 have been observed in Alzheimer's and other neurodegenerative conditions. These alterations could be influenced by genetic or epigenetic factors and contribute to disease pathology.
Currently, there are no known specific inhibitors or activators of APPBP2. However, compounds targeting other proteins involved in APP processing, such as gamma-secretase inhibitors or modulators, are being explored in the context of Alzheimer's disease treatment.
Customer Reviews (4)
Write a reviewthe APPBP2 protein's high quality, dependable performance, and comprehensive technical support make it an excellent choice for researchers seeking to investigate angiopoietin-related biology and unravel the complexities of vascular development and pathogenesis.
the APPBP2 protein's versatility extends beyond its proven usefulness in in vitro experiments.
Its versatility allows researchers to explore APPBP2's involvement in diverse biological processes and fully uncover its functional role.
It can also be employed in various molecular biology techniques, such as Western blotting, immunoprecipitation, or protein-protein interaction studies.
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