Arfgap3
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Official Full Name
ADP-ribosylation factor GTPase activating protein 3
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Overview
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008] -
Synonyms
ARFGAP3; ADP-ribosylation factor GTPase activating protein 3; ARFGAP1; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3; ADP-ribosylation factor GTPase activating protein 1;
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- Involved Pathway
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- Interacting Protein
- Arfgap3 Related Articles
Arfgap3 involved in several pathways and played different roles in them. We selected most pathways Arfgap3 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Arfgap3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | PDGFRA;SPG21;EHD1B;ADRB3B;ASAP1;RAB11FIP1;CHMP5;EPN2;CHMP2BB |
Arfgap3 has several biochemical functions, for example, GTPase activator activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Arfgap3 itself. We selected most functions Arfgap3 had, and list some proteins which have the same functions with Arfgap3. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | ARHGAP36;DAB2IPB;RGS9A;LRRK2;PLCB1;AGAP2;ARAP3;DEPDC1A;TBC1D5 |
metal ion binding | CHSY1;PHYH;FHL1A;AMDHD1;NAIP1;TRIM109;SDHC;PDLIM5B;RAB11FIP3 |
protein binding | CALML3;PKD2L1;COL10A1;RAD51C;PPFIA1;LAPTM5;FOXN3;SCRIB;PAXIP1 |
protein transporter activity | VPS26A;CALCR;RAB4A;CCT6B;KPNA2;ZFYVE16;FRAG1;AP3S1;SOSTDC1B |
Arfgap3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Arfgap3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Arfgap3.
ZDHHC17; HTT; CD14; CXCL8; rbsB5; TRIM26
- Q&As
- Reviews
Q&As (15)
Ask a questionCurrently, there are no known specific inhibitors or modulators developed specifically for ARFGAP3. However, small molecules or compounds that target the ARF-ARFGAP system in general may indirectly affect ARFGAP3 activity.
Yes, ARFGAP3 interacts with several proteins involved in membrane trafficking and remodeling processes. These include ARF family GTPases, SNARE proteins, clathrin, and various adaptor proteins. These interactions play a role in vesicle formation, cargo sorting, and membrane fusion events.
Yes, ARFGAP3 interacts with various proteins involved in vesicle trafficking and membrane dynamics. For example, it has been found to associate with coatomer protein complex I (COPI) subunits, cytoskeleton-related proteins, and lipid-modifying enzymes such as phospholipase D1 (PLD1). These interactions suggest its involvement in the regulation of vesicle formation and lipid metabolism.
ARFGAP3 is involved in various physiological processes, including intracellular vesicle trafficking, membrane remodeling, Golgi organization, and regulated secretion. It also plays a role in cell migration, adhesion, and cytokinesis. The precise functions of ARFGAP3 can vary depending on the specific cell type and context.
Yes, ARFGAP3 is involved in protein sorting and trafficking processes within the cell. It functions as a GTPase-activating protein (GAP) for ARF GTPases, which regulate the formation of coat protein complexes involved in vesicle budding and cargo selection. By controlling the activity of ARF GTPases, ARFGAP3 influences the dynamics of vesicular trafficking.
There is limited research on the role of ARFGAP3 in cancer. However, some studies suggest that ARFGAP3 may be involved in cancer cell migration and invasion, indicating its potential contribution to cancer progression. Further investigation is required to fully understand the implications of ARFGAP3 in cancer biology.
ARFGAP3 plays a role in COPI vesicle formation, which is involved in retrograde transport from the Golgi to the endoplasmic reticulum. It promotes the disassembly of COPI coats from transport vesicles, allowing cargo release and subsequent vesicle fusion.
Yes, researchers use several approaches to study ARFGAP3 function. These include gene knockout or knockdown techniques in cell lines or model organisms to investigate the phenotypic effects of ARFGAP3 loss. Immunofluorescence, live-cell imaging, and biochemical assays are also used to examine protein localization, interactions, and activity. Additionally, in vitro reconstitution experiments and structural analyses provide insights into the mechanistic details of ARFGAP3 function.
Currently, mutations in ARFGAP3 have been linked to autosomal recessive spastic paraplegia type 49 (SPG49). SPG49 is a rare neurodegenerative disorder characterized by progressive lower limb weakness and spasticity. However, more research is needed to fully understand the genetic landscape associated with ARFGAP3 mutations.
While ARFGAP3 is primarily known for its role in membrane trafficking, it has been implicated in various signaling pathways as well. For example, ARFGAP3 may interact with components of the phosphoinositide 3-kinase (PI3K) signaling pathway, affecting downstream signaling events. However, further research is needed to fully elucidate the extent and mechanisms of ARFGAP3 involvement in signaling pathways.
ARFGAP3 is critical for maintaining proper protein trafficking and Golgi function. It influences processes such as Golgi organization, endocytic trafficking, and protein secretion. Additionally, studies have implicated ARFGAP3 in cellular processes like cell adhesion and migration.
Yes, alternative splicing of the ARFGAP3 gene leads to the generation of different isoforms. These isoforms may possess distinct structural and functional properties, allowing for specificity in their cellular roles.
ARFGAP3 is evolutionarily conserved and found in various organisms, including mammals, birds, amphibians, and some invertebrates. Its presence across different species suggests its importance in fundamental cellular processes.
Yes, ARFGAP3 has been implicated in membrane curvature regulation, specifically in the context of forming tubular structures during membrane remodeling and vesicle trafficking processes. It interacts with proteins involved in shaping membranes and may contribute to membrane curvature through these interactions.
Some research suggests that ARFGAP3 mutations may be associated with certain neurological disorders, such as autosomal recessive spastic paraplegia. However, further studies are needed to fully understand the implications of ARFGAP3 in disease.
Customer Reviews (8)
Write a reviewIts exceptional properties and reliable results make it a valuable tool in various experimental applications.
Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.
By utilizing the ARFGAP3 protein, researchers can confidently explore the intricate details of protein structures and gain invaluable insights into their functionality.
Highly recommended and known for its outstanding performance in ELISA, the argO protein is a top choice for researchers in protein electron microscopy structure analysis.
Its remarkable specificity and functionality have allowed me to investigate various cellular processes with precision and confidence.
With their assistance, I have been able to maximize the potential of the ARFGAP3 Protein and achieve even better results.
the manufacturer's support has been instrumental in assisting me throughout my work with the ARFGAP3 protein.
Its exceptional quality ensures accurate data and supports the validity of my research findings.
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